IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0147351.html

Effect of Marine-Derived n-3 Polyunsaturated Fatty Acids on Major Eicosanoids: A Systematic Review and Meta-Analysis from 18 Randomized Controlled Trials

Author

Listed:
  • Jiajing Jiang
  • Kelei Li
  • Fenglei Wang
  • Bo Yang
  • Yuanqing Fu
  • Jusheng Zheng
  • Duo Li

Abstract

Background: Marine-derived n-3 polyunsaturated fatty acids (PUFA) may have a beneficial effect on inflammation via lowering pro-inflammatory eicosanoid concentrations. We aimed to assess the effect of marine-derived n-3 PUFA on prostaglandin E2 (PGE2), thromboxane B2 (TXB2), and leukotriene B4 (LTB4) through systematic review and meta-analysis of randomized controlled trials. Method and Findings: A structured search strategy on PubMed, Web of Science and Cochrane up to November 2015 was undertaken in this meta-analysis. Standard mean difference was used to calculate the effect size of marine-derived n-3 PUFA on PGE2, TXB2 and LTB4 in a random-effect model. A total of 18 RCTs with 826 subjects were included in this systematic review and meta-analysis. Supplementation of marine-derived n-3 PUFA significantly decreased concentrations of TXB2 in serum/plasma in subjects with high risk of cardiovascular diseases (SMD:-1.26; 95% CI: -1.65, -0.86) and LTB4 in neutrophils in unhealthy subjects (subjects with non-autoimmune chronic diseases or auto-immune diseases) (SMD:-0.59: 95% CI: -1.02, -0.16). Subgroup analyses showed a significant reduction of LTB4 in subjects with rheumatoid arthritis (SMD: -0.83; 95% CI: -1.37, -0.29), but not in non-autoimmune chronic disease patients (SMD: -0.33; 95% CI: -0.97, 0.31). No significant publication bias was shown in the meta-analysis. Conclusions: Marine-derived n-3 PUFA had a beneficial effect on reducing the concentration of TXB2 in blood of subjects with high risk of CVD as well as LTB4 in neutrophils in unhealthy subjects, and that subjects with RA showed lower LTB4 content with supplementation of marine-derived n-3 PUFA.

Suggested Citation

  • Jiajing Jiang & Kelei Li & Fenglei Wang & Bo Yang & Yuanqing Fu & Jusheng Zheng & Duo Li, 2016. "Effect of Marine-Derived n-3 Polyunsaturated Fatty Acids on Major Eicosanoids: A Systematic Review and Meta-Analysis from 18 Randomized Controlled Trials," PLOS ONE, Public Library of Science, vol. 11(1), pages 1-18, January.
    • Handle: RePEc:plo:pone00:0147351
    DOI: 10.1371/journal.pone.0147351
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0147351
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0147351&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0147351?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Gary S. Firestein, 2003. "Evolving concepts of rheumatoid arthritis," Nature, Nature, vol. 423(6937), pages 356-361, May.
    2. Gökhan S. Hotamisligil, 2006. "Inflammation and metabolic disorders," Nature, Nature, vol. 444(7121), pages 860-867, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Piontak, Joy Rayanne & Russell, Michael A. & Danese, Andrea & Copeland, William E. & Hoyle, Rick H. & Odgers, Candice L., 2017. "Violence exposure and adolescents' same-day obesogenic behaviors: New findings and a replication," Social Science & Medicine, Elsevier, vol. 189(C), pages 145-151.
    2. Benjamin Onyema Eledo & Edidiong Tommy & Emmanuel Onuoha & Kingsley Dunga & Okezie Okamgba, 2020. "The Prevalence of Rheumatoid Arthritis in the Elderly that attend Pilgrimage Centre, Elele, Nigeria," European Journal of Medical and Health Sciences, European Open Science, vol. 2(3), May.
    3. Hyemin Jeong & Young-Soo Chang & Sun Young Baek & Seon Woo Kim & Yeong Hee Eun & In Young Kim & Jaejoon Lee & Eun-Mi Koh & Hoon-Suk Cha, 2016. "Evaluation of Audiometric Test Results to Determine Hearing Impairment in Patients with Rheumatoid Arthritis: Analysis of Data from the Korean National Health and Nutrition Examination Survey," PLOS ONE, Public Library of Science, vol. 11(10), pages 1-14, October.
    4. Hua Jiang & Wen-Hua Yan & Chan-Juan Li & An-Ping Wang & Jing-Tao Dou & Yi-Ming Mu, 2014. "Elevated White Blood Cell Count Is Associated with Higher Risk of Glucose Metabolism Disorders in Middle-Aged and Elderly Chinese People," IJERPH, MDPI, vol. 11(5), pages 1-13, May.
    5. Seok Hui Kang & Kyu Hyang Cho & Jun Young Do, 2019. "Association between periodontitis and cardiometabolic risk: Results from the Korean National Health and Nutrition Examination Survey 2008-2014," PLOS ONE, Public Library of Science, vol. 14(4), pages 1-12, April.
    6. Goosby, Bridget J. & Cheadle, Jacob E. & McDade, Thomas, 2016. "Birth weight, early life course BMI, and body size change: Chains of risk to adult inflammation?," Social Science & Medicine, Elsevier, vol. 148(C), pages 102-109.
    7. Seung Jin Han & Kyoung Hwa Ha & Ja Young Jeon & Hae Jin Kim & Kwan Woo Lee & Dae Jung Kim, 2015. "Impact of Cadmium Exposure on the Association between Lipopolysaccharide and Metabolic Syndrome," IJERPH, MDPI, vol. 12(9), pages 1-14, September.
    8. Leena R Baghdadi & Richard J Woodman & E Michael Shanahan & Arduino A Mangoni, 2015. "The Impact of Traditional Cardiovascular Risk Factors on Cardiovascular Outcomes in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(2), pages 1-18, February.
    9. repec:plo:pone00:0099862 is not listed on IDEAS
    10. Antonio Julià & Alba Erra & Carles Palacio & Carlos Tomas & Xavier Sans & Pere Barceló & Sara Marsal, 2009. "An Eight-Gene Blood Expression Profile Predicts the Response to Infliximab in Rheumatoid Arthritis," PLOS ONE, Public Library of Science, vol. 4(10), pages 1-8, October.
    11. Mai S. Sater & Zainab H. A. Malalla & Muhalab E. Ali & Hayder A. Giha, 2025. "A Panel of Diverse Inflammatory Biomarkers Is Not Associated with BMI-Calibrated Obesity nor with Dyslipidemia or Dysglycemia in Clinically Healthy Adults Aged 20 to 40 Years," IJERPH, MDPI, vol. 22(2), pages 1-15, January.
    12. Xingzhou Tian & Qi Lu, 2022. "Anthocyanins in Dairy Cow Nutrition: A Review," Agriculture, MDPI, vol. 12(11), pages 1-13, October.
    13. Marie Dubar & Isabelle Clerc-Urmès & Cédric Baumann & Céline Clément & Corentine Alauzet & Catherine Bisson, 2020. "Relations of Psychosocial Factors and Cortisol with Periodontal and Bacterial Parameters: A Prospective Clinical Study in 30 Patients with Periodontitis Before and After Non-Surgical Treatment," IJERPH, MDPI, vol. 17(20), pages 1-19, October.
    14. repec:plo:pcbi00:1001105 is not listed on IDEAS
    15. Li He & Bingbing Fan & Chunxia Li & Yanlin Qu & Ying Liu & Tao Zhang, 2023. "Association between Body Mass Index and Diabetes Mellitus Are Mediated through Endogenous Serum Sex Hormones among Menopause Transition Women: A Longitudinal Cohort Study," IJERPH, MDPI, vol. 20(3), pages 1-10, January.
    16. Surapon Tangvarasittichai, 2018. "Iron Homeostasis and Diabetes Risk," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 7(4), pages 79-88, July.
    17. Effrossyni Gkrania-Klotsas & Zheng Ye & Andrew J Cooper & Stephen J Sharp & Robert Luben & Mary L Biggs & Liang-Kung Chen & Kuppan Gokulakrishnan & Markolf Hanefeld & Erik Ingelsson & Wen-An Lai & Shi, 2010. "Differential White Blood Cell Count and Type 2 Diabetes: Systematic Review and Meta-Analysis of Cross-Sectional and Prospective Studies," PLOS ONE, Public Library of Science, vol. 5(10), pages 1-11, October.
    18. Chi Ching Chang & Chi Sheng Chiou & Hsiu Li Lin & Li Hsuan Wang & Yu Sheng Chang & Hsiu-Chen Lin, 2015. "Increased Risk of Acute Pancreatitis in Patients with Rheumatoid Arthritis: A Population-Based Cohort Study," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-11, August.
    19. Ren-Nan Feng & Chen Zhao & Chang-Hao Sun & Ying Li, 2011. "Meta-Analysis of TNF 308 G/A Polymorphism and Type 2 Diabetes Mellitus," PLOS ONE, Public Library of Science, vol. 6(4), pages 1-5, April.
    20. Ishraq Abdul Ameer Salih* & Rabab Omran, 2018. "The Effects of Gene Polymorphisms in Interleukin-4 on the Susceptibility of Rheumatoid Arthritis in a Iraq Population," Journal of Biotechnology Research, Academic Research Publishing Group, vol. 4(10), pages 76-79, 10-2018.
    21. Ann-Kathrin Lederer & Maximilian Andreas Storz & Roman Huber & Luciana Hannibal & Elena Neumann, 2022. "Plasma Leptin and Adiponectin after a 4-Week Vegan Diet: A Randomized-Controlled Pilot Trial in Healthy Participants," IJERPH, MDPI, vol. 19(18), pages 1-14, September.
    22. Farman, Muhammad & Ahmad, Aqeel & Zehra, Anum & Nisar, Kottakkaran Sooppy & Hincal, Evren & Akgul, Ali, 2024. "Analysis and controllability of diabetes model for experimental data by using fractional operator," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 218(C), pages 133-148.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0147351. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.