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High-Sensitivity C-Reactive Protein Elevation Is Independently Associated with Subclinical Renal Impairment in the Middle-Aged and Elderly Population—A Community-Based Study in Northern Taiwan

Author

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  • Hai-Hua Chuang

    (Department of Family Medicine, Chang-Gung Memorial Hospital, Taipei & Linkou Branch, Taoyuan 33305, Taiwan
    College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan
    Department of Industrial Engineering and Management, National Taipei University of Technology, Taipei 10608, Taiwan
    Obesity Institute & Genomic Medicine Institute, Geisinger, Danville, PA 17822, USA)

  • Rong-Ho Lin

    (Department of Industrial Engineering and Management, National Taipei University of Technology, Taipei 10608, Taiwan)

  • Wen-Cheng Li

    (Department of Family Medicine, Chang-Gung Memorial Hospital, Taipei & Linkou Branch, Taoyuan 33305, Taiwan)

  • Wei-Chung Yeh

    (Department of Family Medicine, Chang-Gung Memorial Hospital, Taipei & Linkou Branch, Taoyuan 33305, Taiwan)

  • Yen-An Lin

    (Department of Family Medicine, Chang-Gung Memorial Hospital, Taipei & Linkou Branch, Taoyuan 33305, Taiwan)

  • Jau-Yuan Chen

    (Department of Family Medicine, Chang-Gung Memorial Hospital, Taipei & Linkou Branch, Taoyuan 33305, Taiwan
    College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan)

Abstract

This cross-sectional study aimed to investigate the associations between high-sensitivity C-reactive protein (hs-CRP) and renal impairment (RI) among middle-aged and elderly people. We collected and analyzed demographic, anthropometric, metabolic, and renal function data in a community-based population in Northern Taiwan. We excluded subjects with acute inflammation from this study and defined RI as the presence of urinary albumin–creatinine ratio 30–300 mg/g or an estimated glomerular filtration rate of <60 mL/min/1.73 m 2 . There were 131, 125, and 125 participants in the low (≤0.80 mg/L), middle (0.81–1.76 mg/L), and high (>1.77 mg/L) hs-CRP tertiles, respectively. hs-CRP exhibited significantly positive correlations with body mass index, waist circumference, systolic blood pressure, triglyceride, and fasting plasma glucose, and a negative correlation with high-density lipoprotein. The prevalence and odds ratio of RI significantly increased across hs-CRP tertiles from low to high, and this trend remained significant after adjusting for the conventional cardiometabolic risk factors. hs-CRP ≥ 1.61 mg/L in the total group and ≥2.03 mg/L in the elderly group accurately predicted RI ( p = 0.01 and 0.03, respectively). These findings suggest that we should carefully evaluate the renal function for at-risk individuals with hs-CRP elevation.

Suggested Citation

  • Hai-Hua Chuang & Rong-Ho Lin & Wen-Cheng Li & Wei-Chung Yeh & Yen-An Lin & Jau-Yuan Chen, 2020. "High-Sensitivity C-Reactive Protein Elevation Is Independently Associated with Subclinical Renal Impairment in the Middle-Aged and Elderly Population—A Community-Based Study in Northern Taiwan," IJERPH, MDPI, vol. 17(16), pages 1-10, August.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:16:p:5878-:d:398605
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    References listed on IDEAS

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    1. Gökhan S. Hotamisligil, 2006. "Inflammation and metabolic disorders," Nature, Nature, vol. 444(7121), pages 860-867, December.
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    Cited by:

    1. Won Ju Hwang & Mi Jeong Kim, 2022. "Toward Public Health Wellness: Psychosocial & Physical Health in the Community," IJERPH, MDPI, vol. 19(9), pages 1-4, April.

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