IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v13y2016i2p220-d63851.html
   My bibliography  Save this article

Association between Polymorphisms and Haplotype in the ABCA1 Gene and Overweight/Obesity Patients in the Uyghur Population of China

Author

Listed:
  • Ming-Hong Yao

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China
    These authors contributed equally to this work.)

  • Jia He

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China
    These authors contributed equally to this work.)

  • Ru-Lin Ma

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China)

  • Yu-Song Ding

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China)

  • Heng Guo

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China)

  • Yi-Zhong Yan

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China)

  • Jing-Yu Zhang

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China)

  • Jia-Ming Liu

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China)

  • Mei Zhang

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China)

  • Dong-Shen Rui

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China)

  • Qiang Niu

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China)

  • Shu-Xia Guo

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China)

Abstract

Objective : This study aimed to detect the association between polymorphisms and haplotype in the ATP-binding cassette transporter A1 (ABCA1) gene and overweight/obese Uyghur patients in China. Methods : A total of 259 overweight/obese patients and 276 normal weight subjects, which were randomly selected from among 3049 adult Uyghurs, were matched for age. We genotyped ABCA1 single nucleotide polymorphisms of rs2515602, rs3890182, rs2275542, rs2230806, rs1800976, and rs4149313. Results : (1) The genotypic and allelic frequencies of rs2515602 and rs4149313 differed between the control group and case group. The genotypic frequency of rs2275542 also differed between the control group and case group ( p < 0.05); (2) rs2515602, rs2230806, and rs4149313 polymorphisms were significantly related to risk of overweight/obese; (3) a significant linkage disequilibrium (LD) was observed between the ABCA1 gene rs2275542 with rs3890182 and rs2515602 with rs4149313. (4) the C-C-C-A-G-G, T-C-G-A-G-G, and T-T-G-G-G-A haplotypes were significant in normal weight and overweight/obese subjects ( p < 0.05); (5) the levels of HDL-C (rs2515602, rs2275542, rs4149313) in normal weight subjects were different among the genotypes ( p < 0.05); the levels of TC, LDL-C and TG (rs1800976) in overweight/obese subjects were different among the genotypes ( p < 0.05). Conclusions: The rs2515602, rs4149313, and rs2275542 polymorphisms were associated with overweight/obese conditions among Uyghurs. Strong LD was noted between rs2275542 with rs3890182 and rs2515602 with rs4149313. The C-C-C-A-G-G and T-C-G-A-G-G haplotypes may serve as risk factors of overweight/obesity among Uyghurs. The T-T-G-G-G-A haplotype may serve as a protective factor of overweight/obesity among Uyghurs. Rs2515602, rs2275542, rs4149313, and rs1800976 polymorphisms in the ABCA1 gene may influence lipid profiles.

Suggested Citation

  • Ming-Hong Yao & Jia He & Ru-Lin Ma & Yu-Song Ding & Heng Guo & Yi-Zhong Yan & Jing-Yu Zhang & Jia-Ming Liu & Mei Zhang & Dong-Shen Rui & Qiang Niu & Shu-Xia Guo, 2016. "Association between Polymorphisms and Haplotype in the ABCA1 Gene and Overweight/Obesity Patients in the Uyghur Population of China," IJERPH, MDPI, vol. 13(2), pages 1-12, February.
    • Handle: RePEc:gam:jijerp:v:13:y:2016:i:2:p:220-:d:63851
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/13/2/220/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/13/2/220/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Peter G. Kopelman, 2000. "Obesity as a medical problem," Nature, Nature, vol. 404(6778), pages 635-643, April.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Jia He & Rulin Ma & Jiaming Liu & Mei Zhang & Yusong Ding & Heng Guo & Lati Mu & Jingyu Zhang & Bin Wei & Yizhong Yan & Jiaolong Ma & Hongrui Pang & Shugang Li & Shuxia Guo, 2017. "The Optimal Ethnic-Specific Waist-Circumference Cut-Off Points of Metabolic Syndrome among Low-Income Rural Uyghur Adults in Far Western China and Implications in Preventive Public Health," IJERPH, MDPI, vol. 14(2), pages 1-12, February.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Mirela DAMIAN & Antoanela OLTEAN & Cosmin DAMIAN, 2018. "The Impact of sedentary behavior on health and the need for physical activity in children and adolescents," Revista romaneasca pentru educatie multidimensionala - Journal for Multidimensional Education, Editura Lumen, Department of Economics, vol. 10(1), pages 71-83, March.
    2. Krzysztof Kościński, 2012. "Hand attractiveness—its determinants and associations with facial attractiveness," Behavioral Ecology, International Society for Behavioral Ecology, vol. 23(2), pages 334-342.
    3. Colette Cunningham-Myrie & Katherine P Theall & Novie Younger-Coleman & Lisa-Gaye Greene & Parris Lyew-Ayee & Rainford Wilks, 2021. "Associations of neighborhood physical and crime environments with obesity-related outcomes in Jamaica," PLOS ONE, Public Library of Science, vol. 16(4), pages 1-19, April.
    4. Yangchang Zhang & Yang Xiong & Jia Dong & Tingting Guo & Xiaoman Tang & Yong Zhao, 2018. "Caffeinated Drinks Intake, Late Chronotype, and Increased Body Mass Index among Medical Students in Chongqing, China: A Multiple Mediation Model," IJERPH, MDPI, vol. 15(8), pages 1-12, August.
    5. Kim, Ji-Il & Yu, Chia-Yuan & Woo, Ayoung, 2023. "The impacts of visual street environments on obesity: The mediating role of walking behaviors," Journal of Transport Geography, Elsevier, vol. 109(C).
    6. Mingzhu Zhou & Na Zhang & Yu Zhang & Xinyu Yan & Muxia Li & Wen Guo & Xiaohui Guo & Hairong He & Kaiwei Guo & Guansheng Ma, 2021. "Effect of Mobile-Based Lifestyle Intervention on Weight Loss among the Overweight and Obese Elderly Population in China: A Randomized Controlled Trial," IJERPH, MDPI, vol. 18(16), pages 1-13, August.
    7. Changhyun Roh & Min-Kyoung Park & Hee-June Shin & Insub Kim & Jin Kyu Kim & Uhee Jung, 2012. "Anti-Obesity Effect of Nepetae spica Extract in High-Fat Mice," Agriculture, MDPI, vol. 2(3), pages 1-7, August.
    8. Eduardo Guerreiro & João Botelho & Vanessa Machado & Luís Proença & José João Mendes & Ana Cristina Manso, 2023. "Caries Experience and Risk Indicators in a Portuguese Population: A Cross-Sectional Study," IJERPH, MDPI, vol. 20(3), pages 1-12, January.
    9. Zeng, Wu & Eisenberg, Dan T.A. & Jovel, Karla Rubio & Undurraga, Eduardo A. & Nyberg, Colleen & Tanner, Susan & Reyes-García, Victoria & Leonard, William R. & Castaño, Juliana & Huanca, Tomás & McDade, 2013. "Adult obesity: Panel study from native Amazonians," Economics & Human Biology, Elsevier, vol. 11(2), pages 227-235.
    10. Odelia Rosin, 2008. "The Economic Causes Of Obesity: A Survey," Journal of Economic Surveys, Wiley Blackwell, vol. 22(4), pages 617-647, September.
    11. Costa-Font, Joan & Gil, Joan, 2008. "What lies behind socio-economic inequalities in obesity in Spain A decomposition approach," Food Policy, Elsevier, vol. 33(1), pages 61-73, February.
    12. Johansson, Edvard & Böckerman, Petri & Kiiskinen, Urpo & Heliövaara, Markku, 2009. "Obesity and labour market success in Finland: The difference between having a high BMI and being fat," Economics & Human Biology, Elsevier, vol. 7(1), pages 36-45, March.
    13. Carleton Schade & David Pimentel, 2010. "Population crash: prospects for famine in the twenty-first century," Environment, Development and Sustainability: A Multidisciplinary Approach to the Theory and Practice of Sustainable Development, Springer, vol. 12(2), pages 245-262, April.
    14. L. Pieroni & D. Lanari & L. Salmasi, 2013. "Food prices and overweight patterns in Italy," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 14(1), pages 133-151, February.
    15. Smith, Trenton G, 2002. "Obesity and Nature's Thumbprint: How Modern Waistlines Can Inform Economic Theory," University of California at Santa Barbara, Economics Working Paper Series qt31g1m028, Department of Economics, UC Santa Barbara.
    16. D. Chen & J. Kang & L. Li & H. Ma, 2016. "Long-term administration of DHEA prevents fat deposition in rats fed a high-fat diet," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 61(4), pages 177-185.
    17. Guyeol Jeong & Buongo Chun, 2021. "Analysis of the Relationship between Obesity Factors and Health-Related Physical Fitness Factors among People with Intellectual Disabilities in South Korea," IJERPH, MDPI, vol. 18(12), pages 1-11, June.
    18. Katrina Kosec & Jie Song, 2021. "The effects of income fluctuations on undernutrition and overnutrition across the lifecycle," Health Economics, John Wiley & Sons, Ltd., vol. 30(10), pages 2487-2509, September.
    19. Johansson, Edvard & Böckerman, Petri & Kiiskinen, Urpo & Heliövaara, Markku, 2007. "The Effect of Obesity on Wages and Employment: The Difference Between Having a High BMI and Being Fat," Working Papers 528, Hanken School of Economics.
    20. Monira I. Aldhahi & Wafa K. Al Khalil & Rawan B. Almutiri & Mada M. Alyousefi & Bayader S. Alharkan & Haya AnNasban, 2022. "Effect of Weight Self-Stigma and Self-Esteem on Aerobic Exercise Capacity in Adult Women with Different Body Compositions," IJERPH, MDPI, vol. 19(2), pages 1-12, January.

    More about this item

    Keywords

    Uyghur; ABCA1; polymorphism; haplotype; overweight/obese;
    All these keywords.

    JEL classification:

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:13:y:2016:i:2:p:220-:d:63851. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.