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Stability analysis of a fractional-order novel hepatitis B virus model with immune delay based on Caputo-Fabrizio derivative

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  • Gao, Fei
  • Li, Xiling
  • Li, Wenqin
  • Zhou, Xianjin

Abstract

In mathematical epidemiology, mathematical models play a vital role in understanding the dynamics of infectious diseases. Therefore, in this paper, a novel mathematical model for the hepatitis B virus (HBV) based on the Caputo-Fabrizio fractional derivative with immune delay is introduced, while taking care of the dimensional consistency of the proposed model. Initially, the existence and uniqueness of the model solutions are proved by Laplace transform and the fixed point theorem. The positivity and boundedness of the solutions are also discussed. Sumudu transform and Picard iteration were used to analyze the stability and iterative solution of the fractional order model of HBV. Further, using the stability theory of fractional order system, the stability and bifurcation of equilibrium point are discussed. Finally, results are presented for different values of the fractional parameter.

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  • Gao, Fei & Li, Xiling & Li, Wenqin & Zhou, Xianjin, 2021. "Stability analysis of a fractional-order novel hepatitis B virus model with immune delay based on Caputo-Fabrizio derivative," Chaos, Solitons & Fractals, Elsevier, vol. 142(C).
    • Handle: RePEc:eee:chsofr:v:142:y:2021:i:c:s0960077920308286
    DOI: 10.1016/j.chaos.2020.110436
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    References listed on IDEAS

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    Cited by:

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    2. Xianbing Cao & Salil Ghosh & Sourav Rana & Homagnic Bose & Priti Kumar Roy, 2023. "Application of an Optimal Control Therapeutic Approach for the Memory-Regulated Infection Mechanism of Leprosy through Caputo–Fabrizio Fractional Derivative," Mathematics, MDPI, vol. 11(17), pages 1-26, August.
    3. Yaagoub, Zakaria & Allali, Karam, 2022. "Fractional HBV infection model with both cell-to-cell and virus-to-cell transmissions and adaptive immunity," Chaos, Solitons & Fractals, Elsevier, vol. 165(P1).
    4. Hoang, Manh Tuan, 2022. "Reliable approximations for a hepatitis B virus model by nonstandard numerical schemes," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 193(C), pages 32-56.
    5. Omame, Andrew & Abbas, Mujahid & Abdel-Aty, Abdel-Haleem, 2022. "Assessing the impact of SARS-CoV-2 infection on the dynamics of dengue and HIV via fractional derivatives," Chaos, Solitons & Fractals, Elsevier, vol. 162(C).
    6. Hoang, Manh Tuan, 2023. "Dynamical analysis of a generalized hepatitis B epidemic model and its dynamically consistent discrete model," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 205(C), pages 291-314.
    7. Du, Feifei & Lu, Jun-Guo, 2021. "New approach to finite-time stability for fractional-order BAM neural networks with discrete and distributed delays," Chaos, Solitons & Fractals, Elsevier, vol. 151(C).

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