IDEAS home Printed from https://ideas.repec.org/a/csb/stintr/v15y2014i3p437-452.html
   My bibliography  Save this article

Joint longitudinal and survival data modelling: an application in anti-diabetes drug therapeutic effect

Author

Listed:
  • Dilip C. Nath
  • Atanu Bhattacharjee

Abstract

The longitudinal and survival analyses are useful tools in the exploration of drug trial data. In both cases the challenge is to deal with correlated repeated observations. Here, the joint modelling for longitudinal and survival data has been carried out via Markov chain Monte Carlo (MCMC) method in type 2 diabetes clinical trials to compare different combinations of drugs, viz. Metformin plus Pioglitazone and Gliclazide plus Pioglitazone. Despite the complexity of the model it has been found relatively easier to implement with WinBugs software. The results have been computed and compared with software R. In both types of the analyses it has been found that no estimates of treatment appear to have significant effect on the evolution of the matter of HBA1c, neither on the longitudinal part nor on the survival one. The Bayesian approach has been considered as an extended tool with classical approach for estimation of clinical trial data analysis.

Suggested Citation

  • Dilip C. Nath & Atanu Bhattacharjee, 2014. "Joint longitudinal and survival data modelling: an application in anti-diabetes drug therapeutic effect," Statistics in Transition new series, Główny Urząd Statystyczny (Polska), vol. 15(3), pages 437-452, June.
    • Handle: RePEc:csb:stintr:v:15:y:2014:i:3:p:437-452
    as

    Download full text from publisher

    File URL: http://index.stat.gov.pl/repec/files/csb/stintr/csb_stintr_v15_2014_i3_n7.pdf
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Robert M. Elashoff & Gang Li & Ning Li, 2008. "A Joint Model for Longitudinal Measurements and Survival Data in the Presence of Multiple Failure Types," Biometrics, The International Biometric Society, vol. 64(3), pages 762-771, September.
    2. David J. Spiegelhalter & Nicola G. Best & Bradley P. Carlin & Angelika Van Der Linde, 2002. "Bayesian measures of model complexity and fit," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 64(4), pages 583-639, October.
    3. Guo X. & Carlin B.P., 2004. "Separate and Joint Modeling of Longitudinal and Event Time Data Using Standard Computer Packages," The American Statistician, American Statistical Association, vol. 58, pages 16-24, February.
    4. Liang Li & Bo Hu & Tom Greene, 2009. "A Semiparametric Joint Model for Longitudinal and Survival Data with Application to Hemodialysis Study," Biometrics, The International Biometric Society, vol. 65(3), pages 737-745, September.
    5. Yueh-Yun Chi & Joseph G. Ibrahim, 2006. "Joint Models for Multivariate Longitudinal and Multivariate Survival Data," Biometrics, The International Biometric Society, vol. 62(2), pages 432-445, June.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Shahedul A. Khan & Nyla Basharat, 2022. "Accelerated failure time models for recurrent event data analysis and joint modeling," Computational Statistics, Springer, vol. 37(4), pages 1569-1597, September.
    2. Tang, Nian-Sheng & Tang, An-Min & Pan, Dong-Dong, 2014. "Semiparametric Bayesian joint models of multivariate longitudinal and survival data," Computational Statistics & Data Analysis, Elsevier, vol. 77(C), pages 113-129.
    3. Rui Martins, 2022. "A flexible link for joint modelling longitudinal and survival data accounting for individual longitudinal heterogeneity," Statistical Methods & Applications, Springer;Società Italiana di Statistica, vol. 31(1), pages 41-61, March.
    4. Wei Yang & Dawei Xie & Qiang Pan & Harold I. Feldman & Wensheng Guo, 2017. "Joint Modeling of Repeated Measures and Competing Failure Events in a Study of Chronic Kidney Disease," Statistics in Biosciences, Springer;International Chinese Statistical Association, vol. 9(2), pages 504-524, December.
    5. repec:jss:jstsof:35:i09 is not listed on IDEAS
    6. Ram Thapa & Harold E. Burkhart & Jie Li & Yili Hong, 2016. "Modeling Clustered Survival Times of Loblolly Pine with Time-dependent Covariates and Shared Frailties," Journal of Agricultural, Biological and Environmental Statistics, Springer;The International Biometric Society;American Statistical Association, vol. 21(1), pages 92-110, March.
    7. Melkamu Molla Ferede & Samuel Mwalili & Getachew Dagne & Simon Karanja & Workagegnehu Hailu & Mahmoud El-Morshedy & Afrah Al-Bossly, 2022. "A Semiparametric Bayesian Joint Modelling of Skewed Longitudinal and Competing Risks Failure Time Data: With Application to Chronic Kidney Disease," Mathematics, MDPI, vol. 10(24), pages 1-21, December.
    8. Martins, Thiago G. & Simpson, Daniel & Lindgren, Finn & Rue, Håvard, 2013. "Bayesian computing with INLA: New features," Computational Statistics & Data Analysis, Elsevier, vol. 67(C), pages 68-83.
    9. Hanze Zhang & Yangxin Huang, 2020. "Quantile regression-based Bayesian joint modeling analysis of longitudinal–survival data, with application to an AIDS cohort study," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 26(2), pages 339-368, April.
    10. An-Min Tang & Nian-Sheng Tang & Dalei Yu, 2023. "Bayesian semiparametric joint model of multivariate longitudinal and survival data with dependent censoring," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 29(4), pages 888-918, October.
    11. Feng Gao & J. Miller & Chengjie Xiong & Julia Beiser & Mae Gordon, 2011. "A joint-modeling approach to assess the impact of biomarker variability on the risk of developing clinical outcome," Statistical Methods & Applications, Springer;Società Italiana di Statistica, vol. 20(1), pages 83-100, March.
    12. Walter Dempsey & Peter McCullagh, 2018. "Survival models and health sequences," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 24(4), pages 550-584, October.
    13. Buddhavarapu, Prasad & Bansal, Prateek & Prozzi, Jorge A., 2021. "A new spatial count data model with time-varying parameters," Transportation Research Part B: Methodological, Elsevier, vol. 150(C), pages 566-586.
    14. Mumtaz, Haroon & Theodoridis, Konstantinos, 2017. "Common and country specific economic uncertainty," Journal of International Economics, Elsevier, vol. 105(C), pages 205-216.
    15. Jesse Elliott & Zemin Bai & Shu-Ching Hsieh & Shannon E Kelly & Li Chen & Becky Skidmore & Said Yousef & Carine Zheng & David J Stewart & George A Wells, 2020. "ALK inhibitors for non-small cell lung cancer: A systematic review and network meta-analysis," PLOS ONE, Public Library of Science, vol. 15(2), pages 1-18, February.
    16. Christina Leuker & Thorsten Pachur & Ralph Hertwig & Timothy J. Pleskac, 2019. "Do people exploit risk–reward structures to simplify information processing in risky choice?," Journal of the Economic Science Association, Springer;Economic Science Association, vol. 5(1), pages 76-94, August.
    17. Francois Olivier & Laval Guillaume, 2011. "Deviance Information Criteria for Model Selection in Approximate Bayesian Computation," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 10(1), pages 1-25, July.
    18. Raggi, Davide & Bordignon, Silvano, 2012. "Long memory and nonlinearities in realized volatility: A Markov switching approach," Computational Statistics & Data Analysis, Elsevier, vol. 56(11), pages 3730-3742.
    19. Angelica Gianfreda & Francesco Ravazzolo & Luca Rossini, 2023. "Large Time‐Varying Volatility Models for Hourly Electricity Prices," Oxford Bulletin of Economics and Statistics, Department of Economics, University of Oxford, vol. 85(3), pages 545-573, June.
    20. Rubio, F.J. & Steel, M.F.J., 2011. "Inference for grouped data with a truncated skew-Laplace distribution," Computational Statistics & Data Analysis, Elsevier, vol. 55(12), pages 3218-3231, December.
    21. Alessandri, Piergiorgio & Mumtaz, Haroon, 2019. "Financial regimes and uncertainty shocks," Journal of Monetary Economics, Elsevier, vol. 101(C), pages 31-46.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:csb:stintr:v:15:y:2014:i:3:p:437-452. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Beata Witek (email available below). General contact details of provider: https://edirc.repec.org/data/gusgvpl.html .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.