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Non-parametric tests for right-censored data with biased sampling


  • Jing Ning
  • Jing Qin
  • Yu Shen


Testing the equality of two survival distributions can be difficult in a prevalent cohort study when non-random sampling of subjects is involved. Owing to the biased sampling scheme, the independent censoring assumption is often violated. Although the issues about biased inference caused by length-biased sampling have been widely recognized in the statistical, epidemiological and economical literature, there is no satisfactory solution for efficient two-sample testing. We propose an asymptotic most efficient non-parametric test by properly adjusting for length-biased sampling. The test statistic is derived from a full likelihood function and can be generalized from the two-sample test to a "k"-sample test. The asymptotic properties of the test statistic under the null hypothesis are derived by using its asymptotic independent and identically distributed representation. We conduct extensive Monte Carlo simulations to evaluate the performance of the test statistics proposed and compare them with the conditional test and the standard log-rank test for various biased sampling schemes and right-censoring mechanisms. For length-biased data, empirical studies demonstrated that the test proposed is substantially more powerful than the existing methods. For general left-truncated data, the test proposed is robust, still maintains accurate control of the type I error rate and is also more powerful than the existing methods, if the truncation patterns and right censoring patterns are the same between the groups. We illustrate the methods by using two real data examples. Copyright (c) 2010 Royal Statistical Society.

Suggested Citation

  • Jing Ning & Jing Qin & Yu Shen, 2010. "Non-parametric tests for right-censored data with biased sampling," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 72(5), pages 609-630.
  • Handle: RePEc:bla:jorssb:v:72:y:2010:i:5:p:609-630

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    References listed on IDEAS

    1. Ruiguang Song & John M. Karon & Edward White & Gary Goldbaum, 2006. "Estimating the Distribution of a Renewal Process from Times at which Events from an Independent Process Are Detected," Biometrics, The International Biometric Society, vol. 62(3), pages 838-846, September.
    2. Bergeron, Pierre-Jerome & Asgharian, Masoud & Wolfson, David B., 2008. "Covariate Bias Induced by Length-Biased Sampling of Failure Times," Journal of the American Statistical Association, American Statistical Association, vol. 103, pages 737-742, June.
    3. Lancaster, Tony, 1979. "Econometric Methods for the Duration of Unemployment," Econometrica, Econometric Society, vol. 47(4), pages 939-956, July.
    4. Peter McCullagh, 2008. "Sampling bias and logistic models," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 70(4), pages 643-677.
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    Cited by:

    1. Yu Shen & Jing Ning & Jing Qin, 2017. "Nonparametric and semiparametric regression estimation for length-biased survival data," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 23(1), pages 3-24, January.

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