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Mixture models in measurement error problems, with reference to epidemiological studies


  • Sylvia Richardson
  • Laurent Leblond
  • Isabelle Jaussent
  • Peter J. Green


The paper focuses on a Bayesian treatment of measurement error problems and on the question of the specification of the prior distribution of the unknown covariates. It presents a flexible semiparametric model for this distribution based on a mixture of normal distributions with an unknown number of components. Implementation of this prior model as part of a full Bayesian analysis of measurement error problems is described in classical set-ups that are encountered in epidemiological studies: logistic regression between unknown covariates and outcome, with a normal or log-normal error model and a validation group. The feasibility of this combined model is tested and its performance is demonstrated in a simulation study that includes an assessment of the influence of misspecification of the prior distribution of the unknown covariates and a comparison with the semiparametric maximum likelihood method of Roeder, Carroll and Lindsay. Finally, the methodology is illustrated on a data set on coronary heart disease and cholesterol levels in blood. Copyright 2002 Royal Statistical Society.

Suggested Citation

  • Sylvia Richardson & Laurent Leblond & Isabelle Jaussent & Peter J. Green, 2002. "Mixture models in measurement error problems, with reference to epidemiological studies," Journal of the Royal Statistical Society Series A, Royal Statistical Society, vol. 165(3), pages 549-566.
  • Handle: RePEc:bla:jorssa:v:165:y:2002:i:3:p:549-566

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    Cited by:

    1. Hansen, Karsten T. & Heckman, James J. & Mullen, K.J.Kathleen J., 2004. "The effect of schooling and ability on achievement test scores," Journal of Econometrics, Elsevier, vol. 121(1-2), pages 39-98.
    2. Ho, Remus K.W. & Hu, Inchi, 2008. "Flexible modelling of random effects in linear mixed models--A Bayesian approach," Computational Statistics & Data Analysis, Elsevier, vol. 52(3), pages 1347-1361, January.
    3. Arana, Jorge E. & Leon, Carmelo J., 2005. "Flexible mixture distribution modeling of dichotomous choice contingent valuation with heterogenity," Journal of Environmental Economics and Management, Elsevier, vol. 50(1), pages 170-188, July.
    4. A. Guolo, 2008. "A Flexible Approach to Measurement Error Correction in Case–Control Studies," Biometrics, The International Biometric Society, vol. 64(4), pages 1207-1214, December.
    5. Cabral, Celso Rômulo Barbosa & Lachos, Víctor Hugo & Zeller, Camila Borelli, 2014. "Multivariate measurement error models using finite mixtures of skew-Student t distributions," Journal of Multivariate Analysis, Elsevier, vol. 124(C), pages 179-198.
    6. Anders Skrondal & Sophia Rabe-Hesketh, 2007. "Latent Variable Modelling: A Survey," Scandinavian Journal of Statistics, Danish Society for Theoretical Statistics;Finnish Statistical Society;Norwegian Statistical Association;Swedish Statistical Association, vol. 34(4), pages 712-745.
    7. David M. Zucker & Malka Gorfine & Yi Li & Mahlet G. Tadesse & Donna Spiegelman, 2013. "A Regularization Corrected Score Method for Nonlinear Regression Models with Covariate Error," Biometrics, The International Biometric Society, vol. 69(1), pages 80-90, March.

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