IDEAS home Printed from https://ideas.repec.org/a/adm/journl/v7y2018i3p64-70.html
   My bibliography  Save this article

Effects of Endogenous n-3PUFA on Body Weight, Autophagy and Inflammation in Mice

Author

Listed:
  • Xin Fang
  • Chao Song
  • YinLin Ge
  • JinYu Zhang

Abstract

The fat-1 transgenic mice were used as models, to investigate the effects of n-3PUFAs on body weight, the expression of inflammation and autophagy in mice, and to explore its mechanism. The mice were divided into two groups: fat-1 transgenic mice and wild-type mice. The body weight and body length were measured and the index of body weight/body length was calculated regularly every week for 8 weeks. Cardiac blood was collected for determination of TG, CT, HDL-C, LDL-C and BG. Frozen sections of liver were stained by Oil Red O to observe the lipid droplets. The expression of autophagy proteins P62, LC3 and ATG7 in the hypothalamus were detected by western blot, and the relative quantitative analysis was performed. Real-time quantitative PCR was used to quantify the mRNA expression of TNF-α, IL-6, IL-1β, IFN-γ, MCP-1, TLR-4 and adiponectin in epididymal adipose tissue. The body weight/body length of fat-1 transgenic mice was significantly lower than that of wild-type mice(P

Suggested Citation

  • Xin Fang & Chao Song & YinLin Ge & JinYu Zhang, 2018. "Effects of Endogenous n-3PUFA on Body Weight, Autophagy and Inflammation in Mice," International Journal of Sciences, Office ijSciences, vol. 7(03), pages 64-70, March.
    • Handle: RePEc:adm:journl:v:7:y:2018:i:3:p:64-70
    DOI: 10.18483/ijSci.1587
    as

    Download full text from publisher

    File URL: https://www.ijsciences.com/pub/article/1587
    Download Restriction: no
    File URL: https://www.ijsciences.com/pub/pdf/V72018031587.pdf
    Download Restriction: no
    File URL: https://libkey.io/10.18483/ijSci.1587?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Hruby, A. & Manson, J.E. & Qi, L. & Malik, V.S. & Rimm, E.B. & Sun, Q. & Willett, W.C. & Hu, F.B., 2016. "Determinants and consequences of obesity," American Journal of Public Health, American Public Health Association, vol. 106(9), pages 1656-1662.
    2. Jing X. Kang & Jingdong Wang & Lin Wu & Zhao B. Kang, 2004. "Fat-1 mice convert n-6 to n-3 fatty acids," Nature, Nature, vol. 427(6974), pages 504-504, February.
    3. Peter G. Kopelman, 2000. "Obesity as a medical problem," Nature, Nature, vol. 404(6778), pages 635-643, April.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Mirela DAMIAN & Antoanela OLTEAN & Cosmin DAMIAN, 2018. "The Impact of sedentary behavior on health and the need for physical activity in children and adolescents," Revista romaneasca pentru educatie multidimensionala - Journal for Multidimensional Education, Editura Lumen, Department of Economics, vol. 10(1), pages 71-83, March.
    2. Krzysztof Kościński, 2012. "Hand attractiveness—its determinants and associations with facial attractiveness," Behavioral Ecology, International Society for Behavioral Ecology, vol. 23(2), pages 334-342.
    3. Colette Cunningham-Myrie & Katherine P Theall & Novie Younger-Coleman & Lisa-Gaye Greene & Parris Lyew-Ayee & Rainford Wilks, 2021. "Associations of neighborhood physical and crime environments with obesity-related outcomes in Jamaica," PLOS ONE, Public Library of Science, vol. 16(4), pages 1-19, April.
    4. Yangchang Zhang & Yang Xiong & Jia Dong & Tingting Guo & Xiaoman Tang & Yong Zhao, 2018. "Caffeinated Drinks Intake, Late Chronotype, and Increased Body Mass Index among Medical Students in Chongqing, China: A Multiple Mediation Model," IJERPH, MDPI, vol. 15(8), pages 1-12, August.
    5. repec:plo:pone00:0143003 is not listed on IDEAS
    6. Chih-Hao Wang & Tadataka Tsuji & Li-Hong Wu & Cheng-Ying Yang & Tian Lian Huang & Mari Sato & Farnaz Shamsi & Yu-Hua Tseng, 2024. "Endothelin 3/EDNRB signaling induces thermogenic differentiation of white adipose tissue," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    7. Kim, Ji-Il & Yu, Chia-Yuan & Woo, Ayoung, 2023. "The impacts of visual street environments on obesity: The mediating role of walking behaviors," Journal of Transport Geography, Elsevier, vol. 109(C).
    8. Mingzhu Zhou & Na Zhang & Yu Zhang & Xinyu Yan & Muxia Li & Wen Guo & Xiaohui Guo & Hairong He & Kaiwei Guo & Guansheng Ma, 2021. "Effect of Mobile-Based Lifestyle Intervention on Weight Loss among the Overweight and Obese Elderly Population in China: A Randomized Controlled Trial," IJERPH, MDPI, vol. 18(16), pages 1-13, August.
    9. Changhyun Roh & Min-Kyoung Park & Hee-June Shin & Insub Kim & Jin Kyu Kim & Uhee Jung, 2012. "Anti-Obesity Effect of Nepetae spica Extract in High-Fat Mice," Agriculture, MDPI, vol. 2(3), pages 1-7, August.
    10. Eduardo Guerreiro & João Botelho & Vanessa Machado & Luís Proença & José João Mendes & Ana Cristina Manso, 2023. "Caries Experience and Risk Indicators in a Portuguese Population: A Cross-Sectional Study," IJERPH, MDPI, vol. 20(3), pages 1-12, January.
    11. Zeng, Wu & Eisenberg, Dan T.A. & Jovel, Karla Rubio & Undurraga, Eduardo A. & Nyberg, Colleen & Tanner, Susan & Reyes-García, Victoria & Leonard, William R. & Castaño, Juliana & Huanca, Tomás & McDade, 2013. "Adult obesity: Panel study from native Amazonians," Economics & Human Biology, Elsevier, vol. 11(2), pages 227-235.
    12. Katharina C. Wirnitzer & Mohamad Motevalli & Derrick R. Tanous & Gerold Wirnitzer & Karl-Heinz Wagner & Armando Cocca & Manuel Schätzer & Werner Kirschner & Clemens Drenowatz & Gerhard Ruedl, 2022. "Study Protocol of “Sustainably Healthy—From Science 2 Highschool & University”—Prevalence of Mixed, Vegetarian, and Vegan Diets Linked to Sports & Exercise among Austrian Tertiary Students and Lecture," IJERPH, MDPI, vol. 19(22), pages 1-24, November.
    13. Kent E. Portney & Garett Thomas Sansom, 2017. "Sustainable Cities and Healthy Cities: Are They the Same?," Urban Planning, Cogitatio Press, vol. 2(3), pages 45-55.
    14. repec:plo:pbio00:0030315 is not listed on IDEAS
    15. Odelia Rosin, 2008. "The Economic Causes Of Obesity: A Survey," Journal of Economic Surveys, Wiley Blackwell, vol. 22(4), pages 617-647, September.
    16. Supa Pengpid & Karl Peltzer, 2021. "Overweight and Obesity among Adults in Iraq: Prevalence and Correlates from a National Survey in 2015," IJERPH, MDPI, vol. 18(8), pages 1-10, April.
    17. Ming-Hong Yao & Jia He & Ru-Lin Ma & Yu-Song Ding & Heng Guo & Yi-Zhong Yan & Jing-Yu Zhang & Jia-Ming Liu & Mei Zhang & Dong-Shen Rui & Qiang Niu & Shu-Xia Guo, 2016. "Association between Polymorphisms and Haplotype in the ABCA1 Gene and Overweight/Obesity Patients in the Uyghur Population of China," IJERPH, MDPI, vol. 13(2), pages 1-12, February.
    18. Cheukyau Luk & Katherine I. Bridge & Nele Warmke & Katie J. Simmons & Michael Drozd & Amy Moran & Amanda D. V. MacCannell & Chew W. Cheng & Sam Straw & Jason L. Scragg & Jessica Smith & Claire H. Ozbe, 2025. "Paracrine role of endothelial IGF-1 receptor in depot-specific adipose tissue adaptation in male mice," Nature Communications, Nature, vol. 16(1), pages 1-15, December.
    19. Costa-Font, Joan & Gil, Joan, 2008. "What lies behind socio-economic inequalities in obesity in Spain A decomposition approach," Food Policy, Elsevier, vol. 33(1), pages 61-73, February.
    20. Johansson, Edvard & Böckerman, Petri & Kiiskinen, Urpo & Heliövaara, Markku, 2009. "Obesity and labour market success in Finland: The difference between having a high BMI and being fat," Economics & Human Biology, Elsevier, vol. 7(1), pages 36-45, March.
    21. Carleton Schade & David Pimentel, 2010. "Population crash: prospects for famine in the twenty-first century," Environment, Development and Sustainability: A Multidisciplinary Approach to the Theory and Practice of Sustainable Development, Springer, vol. 12(2), pages 245-262, April.
    22. L. Pieroni & D. Lanari & L. Salmasi, 2013. "Food prices and overweight patterns in Italy," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 14(1), pages 133-151, February.

    More about this item

    Keywords

    ;
    ;
    ;
    ;

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:adm:journl:v:7:y:2018:i:3:p:64-70. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Staff ijSciences The email address of this maintainer does not seem to be valid anymore. Please ask Staff ijSciences to update the entry or send us the correct address (email available below). General contact details of provider: .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.