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Control of Generalized Error Rates in Multiple Testing

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  • Joseph P. Romano
  • Michael Wolf

Abstract

Consider the problem of testing s hypotheses simultaneously. The usual approach to dealing with the multiplicity problem is to restrict attention to procedures that control the probability of even one false rejection, the familiar familywise error rate (FWER). In many applications, particularly if s is large, one might be willing to tolerate more than one false rejection if the number of such cases is controlled, thereby increasing the ability of the procedure to reject false null hypotheses One possibility is to replace control of the FWER by control of the probability of k or more false rejections, which is called the k-FWER. We derive both single-step and stepdown procedures that control the k-FWER in finite samples or asymptotically, depending on the situation. Lehmann and Romano (2005a) derive some exact methods for this purpose, which apply whenever p-values are available for individual tests; no assumptions are made on the joint dependence of the p-values. In contrast, we construct methods that implicitly take into account the dependence structure of the individual test statistics in order to further increase the ability to detect false null hypotheses. We also consider the false discovery proportion (FDP) defined as the number of false rejections divided by the total number of rejections (and defined to be 0 if there are no rejections). The false discovery rate proposed by Benjamini and Hochberg (1995) controls E(FDP).

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Paper provided by Institute for Empirical Research in Economics - University of Zurich in its series IEW - Working Papers with number 245.

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Handle: RePEc:zur:iewwpx:245

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Keywords: Bootstrap; False Discovery Proportion; False Discovery Rate; Generalized Familywise Error Rates; Multiple Testing; Stepdown Procedure.;

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  1. Joseph P. Romano & Michael Wolf, 2003. "Stepwise multiple testing as formalized data snooping," Economics Working Papers 712, Department of Economics and Business, Universitat Pompeu Fabra.
  2. Joseph P. Romano & Michael Wolf, 2005. "Exact and Approximate Stepdown Methods for Multiple Hypothesis Testing," Journal of the American Statistical Association, American Statistical Association, vol. 100, pages 94-108, March.
  3. Delgado, Miguel A. & Rodriguez-Poo, Juan M. & Wolf, Michael, 2001. "Subsampling inference in cube root asymptotics with an application to Manski's maximum score estimator," Economics Letters, Elsevier, vol. 73(2), pages 241-250, November.
  4. M. Perone Pacifico & C. Genovese & I. Verdinelli & L. Wasserman, 2004. "False Discovery Control for Random Fields," Journal of the American Statistical Association, American Statistical Association, vol. 99, pages 1002-1014, December.
  5. Jason Abrevaya & Jian Huang, 2005. "On the Bootstrap of the Maximum Score Estimator," Econometrica, Econometric Society, vol. 73(4), pages 1175-1204, 07.
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