Scientific Knowledge Dynamics and Relatedness in Bio-Tech Cities
AbstractThis paper investigates the impact of scientific relatedness on knowledge dynamics in biotech at the city level during the period 1989-2008. We assess the extent to which the emergence of new research topics and the disappearance of existing topics in cities are dependent on their degree of scientific relatedness with existing topics in those cities. We make use of the rise and fall of title words in scientific publications in biotech to identify major cognitive developments within the field. We determined the degree of relatedness between 1,028 scientific topics in biotech by means of co-occurrence of pairs of topics in journal articles. We combined this relatedness indicator between topics in biotech with the scientific portfolio of cities (i.e. the topics on which they published previously) to determine how cognitively close a potentially new topic (or an existing topic) is to the scientific portfolio of a city. We analyzed knowledge dynamics at the city level by looking at the entry and exit of topics in the scientific portfolio of 276 cities in the world. We found strong and robust evidence that new scientific topics in biotech tend to emerge systematically in cities where scientifically related topics already exist, while existing scientific topics had a higher probability to disappear from a city when these were weakly related to the scientific portfolio of the city.
Download InfoIf you experience problems downloading a file, check if you have the proper application to view it first. In case of further problems read the IDEAS help page. Note that these files are not on the IDEAS site. Please be patient as the files may be large.
Bibliographic InfoPaper provided by Utrecht University, Section of Economic Geography in its series Papers in Evolutionary Economic Geography (PEEG) with number 1304.
Length: 24 pages
Date of creation: Apr 2013
Date of revision: Apr 2013
relatedness; co-occurrence analysis; knowledge dynamics; geography of biotech; title words;
Other versions of this item:
- Boschma, Ron & Heimeriks, Gaston & Balland, Pierre-Alexandre, 2014. "Scientific knowledge dynamics and relatedness in biotech cities," Research Policy, Elsevier, vol. 43(1), pages 107-114.
- O33 - Economic Development, Technological Change, and Growth - - Technological Change; Research and Development; Intellectual Property Rights - - - Technological Change: Choices and Consequences; Diffusion Processes
- R11 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General Regional Economics - - - Regional Economic Activity: Growth, Development, Environmental Issues, and Changes
- L65 - Industrial Organization - - Industry Studies: Manufacturing - - - Chemicals; Rubber; Drugs; Biotechnology
- D83 - Microeconomics - - Information, Knowledge, and Uncertainty - - - Search, Learning, and Information
This paper has been announced in the following NEP Reports:
- NEP-ALL-2013-04-27 (All new papers)
- NEP-GEO-2013-04-27 (Economic Geography)
- NEP-KNM-2013-04-27 (Knowledge Management & Knowledge Economy)
- NEP-URE-2013-04-27 (Urban & Real Estate Economics)
Please report citation or reference errors to , or , if you are the registered author of the cited work, log in to your RePEc Author Service profile, click on "citations" and make appropriate adjustments.:
- Todtling, Franz & Trippl, Michaela, 2005. "One size fits all?: Towards a differentiated regional innovation policy approach," Research Policy, Elsevier, vol. 34(8), pages 1203-1219, October.
- Leydesdroff, Loet, 1989. "Words and co-words as indicators of intellectual organization," Research Policy, Elsevier, vol. 18(4), pages 209-223, August.
- Roberta Capello, 1999. "Spatial Transfer of Knowledge in High Technology Milieux: Learning Versus Collective Learning Processes," Regional Studies, Taylor & Francis Journals, vol. 33(4), pages 353-365.
- Cohen, Wesley M & Levinthal, Daniel A, 1989. "Innovation and Learning: The Two Faces of R&D," Economic Journal, Royal Economic Society, vol. 99(397), pages 569-96, September.
- Ash Amin & Patrick Cohendet, 2000. "Organisational Learning and Governance Through Embedded Practices," Journal of Management and Governance, Springer, vol. 4(1), pages 93-116, March.
- Steven Klepper, 2007. "Disagreements, Spinoffs, and the Evolution of Detroit as the Capital of the U.S. Automobile Industry," Management Science, INFORMS, vol. 53(4), pages 616-631, April.
- Atkinson, Anthony B & Stiglitz, Joseph E, 1969. "A New View of Technological Change," Economic Journal, Royal Economic Society, vol. 79(315), pages 573-78, September.
- Frank Neffke & Martin Henning & Ron Boschma, 2011.
"How Do Regions Diversify over Time? Industry Relatedness and the Development of New Growth Paths in Regions,"
Clark University, vol. 87(3), pages 237-265, 07.
- Frank Neffke & Martin Henning & Martin Ron Boschma, 2009. "How do regions diversify over time? Industry relatedness and the development of new growth paths in regions," Papers in Evolutionary Economic Geography (PEEG) 0916, Utrecht University, Section of Economic Geography, revised Oct 2009.
- Jarno Hoekman & Koen Frenken & Frank Oort, 2009.
"The geography of collaborative knowledge production in Europe,"
The Annals of Regional Science,
Springer, vol. 43(3), pages 721-738, September.
- Jarno Hoekman & Koen Frenken & Frank van Oort, 2008. "The geography of collaborative knowledge production in Europe," KITeS Working Papers 214, KITeS, Centre for Knowledge, Internationalization and Technology Studies, Universita' Bocconi, Milano, Italy, revised Feb 2008.
- C. A. Hidalgo & B. Klinger & A. -L. Barabasi & R. Hausmann, 2007. "The Product Space Conditions the Development of Nations," Papers 0708.2090, arXiv.org.
- Lucio-Arias, Diana & Leydesdorff, Loet, 2009. "The dynamics of exchanges and references among scientific texts, and the autopoiesis of discursive knowledge," Journal of Informetrics, Elsevier, vol. 3(3), pages 261-271.
- Antonelli, Cristiano, 2003. "Localized Technological Change," Department of Economics and Statistics Cognetti de Martiis LEI & BRICK - Laboratory of Economics of Innovation "Franco Momigliano", Bureau of Research in Innovation, Complexity and Knowledge, Collegio 200305, University of Turin.
- Phil Cooke, 2006. "Global Bioregions: Knowledge Domains, Capabilities and Innovation System Networks," Industry and Innovation, Taylor & Francis Journals, vol. 13(4), pages 437-458.
- Dosi, Giovanni, 1982.
"Technological paradigms and technological trajectories : A suggested interpretation of the determinants and directions of technical change,"
Elsevier, vol. 11(3), pages 147-162, June.
- Dosi, Giovanni, 1993. "Technological paradigms and technological trajectories : A suggested interpretation of the determinants and directions of technical change," Research Policy, Elsevier, vol. 22(2), pages 102-103, April.
- Gaston Heimeriks & Ron Boschma, 2012. "The path- and place-dependent nature of scientific knowledge production in biotech 1986-2008," Papers in Evolutionary Economic Geography (PEEG) 1210, Utrecht University, Section of Economic Geography, revised Jun 2012.
- Hoekman, Jarno & Frenken, Koen & Tijssen, Robert J.W., 2010. "Research collaboration at a distance: Changing spatial patterns of scientific collaboration within Europe," Research Policy, Elsevier, vol. 39(5), pages 662-673, June.
- Jackie Krafft & Francesco Quatraro & Pier-Paolo Saviotti, 2011.
"The Knowledge Base Evolution in Biotechnology: A Social Network Analysis,"
- Jackie Krafft & Francesco Quatraro & Pier Paolo Saviotti, 2011. "The knowledge-base evolution in biotechnology: a social network analysis," Economics of Innovation and New Technology, Taylor & Francis Journals, vol. 20(5), pages 445-475.
- Jackie Krafft & Francesco Quatraro & Pier-Paolo Saviotti, 2011. "The knowledge-base evolution in biotechnology: a social network analysis," Post-Print halshs-00727610, HAL.
- Heiner, Ronald A, 1983. "The Origin of Predictable Behavior," American Economic Review, American Economic Association, vol. 73(4), pages 560-95, September.
- Asheim, Bjorn T & Isaksen, Arne, 2002. " Regional Innovation Systems: The Integration of Local 'Sticky' and Global 'Ubiquitous' Knowledge," The Journal of Technology Transfer, Springer, vol. 27(1), pages 77-86, January.
- Asheim, Bjorn T. & Coenen, Lars, 2005. "Knowledge bases and regional innovation systems: Comparing Nordic clusters," Research Policy, Elsevier, vol. 34(8), pages 1173-1190, October.
- Gaston Heimeriks, 2012. "Interdisciplinarity in biotechnology, genomics and nanotechnology," Science and Public Policy, Oxford University Press, vol. 40(1), pages 97-112, September.
- Frenken, Koen & Hardeman, Sjoerd & Hoekman, Jarno, 2009. "Spatial scientometrics: Towards a cumulative research program," Journal of Informetrics, Elsevier, vol. 3(3), pages 222-232.
- Jeffrey M. Wooldridge, 2003. "Cluster-Sample Methods in Applied Econometrics," American Economic Review, American Economic Association, vol. 93(2), pages 133-138, May.
- Rikard H. Eriksson, 2011. "Localized Spillovers and Knowledge Flows: How Does Proximity Influence the Performance of Plants?," Economic Geography, Clark University, vol. 87(2), pages 127-152, 04.
- Meric S. Gertler, 2003. "Tacit knowledge and the economic geography of context, or The undefinable tacitness of being (there)," Journal of Economic Geography, Oxford University Press, vol. 3(1), pages 75-99, January.
- Simone Strambach & Benjamin Klement, 2011. "Cumulative and Combinatorial Micro-dynamics of Knowledge: The Role of Space and Place in Knowledge Integration," European Planning Studies, Taylor & Francis Journals, vol. 20(11), pages 1843-1866, November.
- van Eck, N.J.P. & Waltman, L., 2009. "How to Normalize Co-Occurrence Data? An Analysis of Some Well-Known Similarity Measures," ERIM Report Series Research in Management ERS-2009-001-LIS, Erasmus Research Institute of Management (ERIM), ERIM is the joint research institute of the Rotterdam School of Management, Erasmus University and the Erasmus School of Economics (ESE) at Erasmus Uni.
- Lynne G. Zucker & Michael R. Darby, 2007. "Star Scientists, Innovation and Regional and National Immigration," NBER Working Papers 13547, National Bureau of Economic Research, Inc.
- Michaela Trippl, 2009. "Islands of Innovation and Internationally Networked Labor Markets: Magnetic Centers for Star Scientists?," SRE-Disc sre-disc-2009_06, Institute for the Environment and Regional Development, Department of Socioeconomics, Vienna University of Economics and Business.
- Stefano Breschi & Francesco Lissoni, 2009. "Mobility of skilled workers and co-invention networks: an anatomy of localized knowledge flows," Journal of Economic Geography, Oxford University Press, vol. 9(4), pages 439-468, July.
- Ron Boschma, 2004. "Competitiveness of Regions from an Evolutionary Perspective," Regional Studies, Taylor & Francis Journals, vol. 38(9), pages 1001-1014.
- Ron Boschma & Asier Minondo & Mikel Navarro, 2012. "The emergence of new industries at the regional level in Spain. A proximity approach based on product-relatedness," Papers in Evolutionary Economic Geography (PEEG) 1201, Utrecht University, Section of Economic Geography, revised Jan 2012.
- M. S. Gertler & Y. M. Levitte, 2005. "Local Nodes in Global Networks: The Geography of Knowledge Flows in Biotechnology Innovation," Industry and Innovation, Taylor & Francis Journals, vol. 12(4), pages 487-507.
- Ron Boschma, 2014. "Towards an evolutionary perspective on regional resilience," Papers in Evolutionary Economic Geography (PEEG) 1409, Utrecht University, Section of Economic Geography, revised Mar 2014.
- Ron Boschma, 2013.
"Constructing Regional Advantage and Smart Specialization: Comparison of Two European Policy Concepts,"
Papers in Evolutionary Economic Geography (PEEG)
1322, Utrecht University, Section of Economic Geography, revised Nov 2013.
- Ron Boschma, 2014. "Constructing Regional Advantage and Smart Specialisation: Comparison of Two European Policy Concepts," SCIENZE REGIONALI, FrancoAngeli Editore, vol. 2014(1), pages 51-68.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: ().
If references are entirely missing, you can add them using this form.