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The Knowledge Base Evolution in Biotechnology: A Social Network Analysis

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Author Info

  • Jackie Krafft

    (GREDEG - Groupe de Recherche en Droit, Economie et Gestion - CNRS : UMR6227 - Université de Nice Sophia-Antipolis)

  • Francesco Quatraro

    (GREDEG - Groupe de Recherche en Droit, Economie et Gestion - CNRS : UMR6227 - Université de Nice Sophia-Antipolis, Department of Economics, University of Turin - University of Turin)

  • Pier-Paolo Saviotti

    (GREDEG - Groupe de Recherche en Droit, Economie et Gestion - CNRS : UMR6227 - Université de Nice Sophia-Antipolis, GAEL - Grenoble Applied Economic laboratory - Aucune)

Abstract

This paper applies the methodological tools typical of social network analysis (SNA) within an evolutionary framework, to investigate the knowledge base dynamics of the biotechnology sector. Knowledge is here considered a collective good represented as a co-relational and a retrieval-interpretative structure. The internal structure of knowledge is described as a network the nodes of which are small units within traces of knowledge, such as patent documents, connected by links determined by their joint utilisation. We used measures referring to the network, like density, and to its nodes, like degree, closeness and betweenness centrality, to provide a synthetic description of the structure of the knowledge base and of its evolution over time. Eventually, we compared such measures with more established properties of the knowledge base calculated on the basis of co-occurrences of technological classes within patent documents. Empirical results show the existence of interesting and meaningful relationships across the different measures, providing support for the use of SNA to study the evolution of the knowledge bases of industrial sectors and their lifecycles.

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Bibliographic Info

Paper provided by HAL in its series Post-Print with number hal-00539002.

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Date of creation: 2011
Date of revision:
Publication status: Published, Economics of Innovation and New Technology, 2011, 20, 5, 445-475
Handle: RePEc:hal:journl:hal-00539002

Note: View the original document on HAL open archive server: http://hal.archives-ouvertes.fr/hal-00539002/en/
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Related research

Keywords: Knowledge Base; Social Network Analysis; Variety; Coherence; Industry lifecycles; exploration/exploitation;

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References

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  1. Acs, Zoltan J. & Anselin, Luc & Varga, Attila, 2002. "Patents and innovation counts as measures of regional production of new knowledge," Research Policy, Elsevier, vol. 31(7), pages 1069-1085, September.
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  4. Jackie Krafft & Francesco Quatraro, 2011. "The dynamics of technological knowledge," Post-Print halshs-00727633, HAL.
  5. Saviotti, Pier Paolo, 2007. "On the dynamics of generation and utilisation of knowledge: The local character of knowledge," Structural Change and Economic Dynamics, Elsevier, vol. 18(4), pages 387-408, December.
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  12. Krafft, Jackie, 2004. "Entry, exit and knowledge: evidence from a cluster in the info-communications industry," Research Policy, Elsevier, vol. 33(10), pages 1687-1706, December.
  13. Pier Saviotti & Koen Frenken, 2008. "Export variety and the economic performance of countries," Journal of Evolutionary Economics, Springer, vol. 18(2), pages 201-218, April.
  14. Thomas Grebel & Jackie Krafft & Pier-Paolo Saviotti, 2006. "On the Life Cycle of Knowledge Intensive Sectors," Revue de l'OFCE, Presses de Sciences-Po, vol. 97(5), pages 63-85.
  15. Koen Frenken & Frank Van Oort & Thijs Verburg, 2007. "Related Variety, Unrelated Variety and Regional Economic Growth," Regional Studies, Taylor & Francis Journals, vol. 41(5), pages 685-697.
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  20. repec:fth:harver:1473 is not listed on IDEAS
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Citations

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Cited by:
  1. repec:hal:wpaper:hal-00686007 is not listed on IDEAS
  2. Francesco Quatraro, 2011. "Knowledge Structure and Regional Economic Growth: The French case," Post-Print halshs-00727630, HAL.
  3. Gaston Heimeriks & Ron Boschma, 2012. "The path- and place-dependent nature of scientific knowledge production in biotech 1986-2008," Papers in Evolutionary Economic Geography (PEEG) 1210, Utrecht University, Section of Economic Geography, revised Jun 2012.
  4. Francesco Quatraro, 2012. "The Co-Evolution of Knowledge and Economic Structure: Evidence from European Regions," GREDEG Working Papers 2012-16, Groupe de REcherche en Droit, Economie, Gestion (GREDEG CNRS), University of Nice Sophia Antipolis.
  5. Michael Dietrich & Jackie Krafft, 2012. "Economics and Theory of the Firm, Chap. 1 of the Handbook on Economics and Theory of the Firm, M. Dietrich and Jackie Krafft (eds), Edward Elgar: Cheltenham, 2012," Post-Print halshs-00742302, HAL.
  6. Alessandra Colombelli & Francesco Quatraro, 2013. "The persistence of firms' knowledge base: A quantile approach to Italian data," Working Papers hal-00867132, HAL.
  7. Colombelli Alessandra & Quatraro Francesco, 2012. "Persistence of innovation and knowledge structure: Evidence from a sample of Italian firms," Department of Economics and Statistics Cognetti de Martiis LEI & BRICK - Laboratory of Economics of Innovation "Franco Momigliano", Bureau of Research in Innovation, Complexity and Knowledge, Collegio 201205, University of Turin.
  8. Quatraro, Francesco, 2010. "Knowledge coherence, variety and economic growth: Manufacturing evidence from Italian regions," Research Policy, Elsevier, vol. 39(10), pages 1289-1302, December.
  9. Consoli,Davide & Elche,Dioni, 2014. "An analysis of the knowledge base of Scientific Research & Development Business Services," INGENIO (CSIC-UPV) Working Paper Series 201401, INGENIO (CSIC-UPV).
  10. Krafft Jackie & Quatraro Francesco & Colombelli Alessandra, 2011. "High Growth Firms and Technological Knowledge: Do gazelles follow exploration or exploitation strategies?," Department of Economics and Statistics Cognetti de Martiis LEI & BRICK - Laboratory of Economics of Innovation "Franco Momigliano", Bureau of Research in Innovation, Complexity and Knowledge, Collegio 201114, University of Turin.
  11. Boschma, Ron & Heimeriks, Gaston & Balland, Pierre-Alexandre, 2014. "Scientific knowledge dynamics and relatedness in biotech cities," Research Policy, Elsevier, vol. 43(1), pages 107-114.
  12. Antonelli, Cristiano, 2013. "Globalization Localized Technological Change and the Knowledge Economy," Department of Economics and Statistics Cognetti de Martiis. Working Papers 201325, University of Turin.
  13. Colombelli Alessandra & Krafft.Jackie & Quatraro Francesco, 2012. "Properties of knowledge base and firm survival: Evidence from a sample of French manufacturing firms," Department of Economics and Statistics Cognetti de Martiis LEI & BRICK - Laboratory of Economics of Innovation "Franco Momigliano", Bureau of Research in Innovation, Complexity and Knowledge, Collegio 201209, University of Turin.
  14. Francesco Quatraro, 2013. "Co-evolutionary patterns in regional knowledge bases and economic structure: evidence from European Regions," Working Papers hal-00992080, HAL.
  15. Ron Boschma & Pierre-Alexandre Balland & Dieter Franz Kogler, 2013. "Relatedness and Technological Change in Cities: The rise and fall of technological knowledge in U.S. metropolitan areas from 1981 to 2010," Papers in Evolutionary Economic Geography (PEEG) 1316, Utrecht University, Section of Economic Geography, revised Sep 2013.

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