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The revolution re-visited: Clinical and genetics research paradigms and the productivity paradox in drug discovery

Citations

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Cited by:

  1. Rossana Mastrandrea & Fabio Montobbio & Gabriele Pellegrino & Massimo Riccaboni & Valerio Sterzi, 2025. "Leveraging Knowledge Networks: Rethinking Technological Value Distribution in mRNA Vaccine Innovations," Papers 2503.14072, arXiv.org.
  2. Ali, Ayfer & Gittelman, Michelle, 2016. "Research paradigms and useful inventions in medicine: Patents and licensing by teams of clinical and basic scientists in Academic Medical Centers," Research Policy, Elsevier, vol. 45(8), pages 1499-1511.
  3. Roy, Raja & Lampert, Curba Morris & Polidoro, Francisco & Kim, Minyoung, 2025. "Creating a breakthrough invention: NASA’s internal knowledge generation for the Space Shuttle," Research Policy, Elsevier, vol. 54(10).
  4. Yaqub, Ohid, 2018. "Serendipity: Towards a taxonomy and a theory," Research Policy, Elsevier, vol. 47(1), pages 169-179.
  5. Anckaert, Paul-Emmanuel, 2025. "When the drugs (don’t) work: The role of science in product commercialization," Research Policy, Elsevier, vol. 54(5).
  6. Ke, Qing, 2020. "Technological impact of biomedical research: The role of basicness and novelty," Research Policy, Elsevier, vol. 49(7).
  7. Llopis, Oscar & DâEste, Pablo & Adrián A. Díaz-Faes, 2018. "Connections matter: the influence of network sparseness, network diversity and a tertius iungens orientation on innovation," INGENIO (CSIC-UPV) Working Paper Series 201801, INGENIO (CSIC-UPV), revised 28 Oct 2019.
  8. Daniel P. Gross & Bhaven N. Sampat, 2022. "Crisis Innovation Policy from World War II to COVID-19," Entrepreneurship and Innovation Policy and the Economy, University of Chicago Press, vol. 1(1), pages 135-181.
  9. Taran Thune & Magnus Gulbrandsen, 2016. "Combining knowledge to generate new ideas. A study of disclosed ideas for life science inventions," Working Papers on Innovation Studies 20161209, Centre for Technology, Innovation and Culture, University of Oslo.
  10. Hoekman, Jarno & Rake, Bastian, 2024. "Geography of authorship: How geography shapes authorship attribution in big team science," Research Policy, Elsevier, vol. 53(2).
  11. Nelson, John P., 2023. "Differential “progressibility” in human know-how: A conceptual overview," Research Policy, Elsevier, vol. 52(2).
  12. Tylecote, Andrew, 2019. "Biotechnology as a new techno-economic paradigm that will help drive the world economy and mitigate climate change," Research Policy, Elsevier, vol. 48(4), pages 858-868.
  13. Ke, Qing, 2020. "An analysis of the evolution of science-technology linkage in biomedicine," Journal of Informetrics, Elsevier, vol. 14(4).
  14. Wang, Xuefeng & Zhang, Shuo & Liu, Yuqin & Du, Jian & Huang, Heng, 2021. "How pharmaceutical innovation evolves: The path from science to technological development to marketable drugs," Technological Forecasting and Social Change, Elsevier, vol. 167(C).
  15. Ingo Stiller & Arjen Witteloostuijn & Bart Cambré, 2022. "Determinants of radical drug innovation: a systematic literature review," Management Review Quarterly, Springer, vol. 72(4), pages 967-1016, December.
  16. Coburn, Josie & Yaqub, Ohid & Ràfols, Ismael & Chataway, Joanna, 2024. "Cross-disease spillover from research funding: Evidence from four diseases," Social Science & Medicine, Elsevier, vol. 349(C).
  17. Chan-Yuan Wong & Hon-Ngen Fung, 2017. "Science-technology-industry correlative indicators for policy targeting on emerging technologies: exploring the core competencies and promising industries of aspirant economies," Scientometrics, Springer;Akadémiai Kiadó, vol. 111(2), pages 841-867, May.
  18. Tan Tran, 2020. "R&D and Knowledge Expertise of French Regions," Papers in Evolutionary Economic Geography (PEEG) 2004, Utrecht University, Department of Human Geography and Spatial Planning, Group Economic Geography, revised Feb 2020.
  19. Ávila-Robinson, Alfonso & Islam, Nazrul & Sengoku, Shintaro, 2019. "Co-evolutionary and systemic study on the evolution of emerging stem cell-based therapies," Technological Forecasting and Social Change, Elsevier, vol. 138(C), pages 324-339.
  20. Anckaert, Paul-Emmanuel & Cassiman, David & Cassiman, Bruno, 2020. "Fostering practice-oriented and use-inspired science in biomedical research," Research Policy, Elsevier, vol. 49(2).
  21. Fiori, Giovana Maria Lanchoti & Basso, Fernanda Gisele & Porto, Geciane Silveira, 2022. "Cooperation in R&D in the pharmaceutical industry: Technological and clinical trial networks in oncology," Technological Forecasting and Social Change, Elsevier, vol. 176(C).
  22. Ribeiro, Barbara & Shapira, Philip, 2020. "Private and public values of innovation: A patent analysis of synthetic biology," Research Policy, Elsevier, vol. 49(1).
  23. Milena Filipova & Yulia Nedelcheva, 2022. "Value-Added Chain Of A New Pharmaceutical Product," Economics and Management, Faculty of Economics, SOUTH-WEST UNIVERSITY "NEOFIT RILSKI", BLAGOEVGRAD, vol. 19(1), pages 65-78.
  24. Yu, Yan & Ibarra, Julio E. & Kumar, Kuldeep & Chergarova, Vasilka, 2021. "Coevolution of cyberinfrastructure development and scientific progress," Technovation, Elsevier, vol. 100(C).
  25. Yaqub, Ohid, 2017. "Testing regimes in clinical trials: Evidence from four polio vaccine trajectories," Research Policy, Elsevier, vol. 46(2), pages 475-484.
  26. Bastian Rake & Pablo D’Este & Maureen McKelvey, 2021. "Exploring network dynamics in science: the formation of ties to knowledge translators in clinical research," Journal of Evolutionary Economics, Springer, vol. 31(5), pages 1433-1464, November.
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