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Economic evaluation alongside n‐of‐1 trials: getting closer to the margin

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  • Jonathan Karnon
  • Nawab Qizilbash

Abstract

The n‐of‐1 trial is a particularly flexible form of randomized controlled trial that involves a single patient receiving multiple episodes of alternative therapies. Although n‐of‐1 trials are only applicable in certain treatment areas, the collection of economic data within such trials may provide unique advantages. This paper illustrates the issues around the use of economic n‐of‐1 trials with a hypothetical example, and discusses their potential for the estimation of individualized cost‐effectiveness. Copyright © 2001 John Wiley & Sons, Ltd.

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  • Jonathan Karnon & Nawab Qizilbash, 2001. "Economic evaluation alongside n‐of‐1 trials: getting closer to the margin," Health Economics, John Wiley & Sons, Ltd., vol. 10(1), pages 79-82, January.
    • Handle: RePEc:wly:hlthec:v:10:y:2001:i:1:p:79-82
    DOI: 10.1002/1099-1050(200101)10:1<79::AID-HEC567>3.0.CO;2-Z
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    3. Jeff Richardson & Erik Nord, 1997. "The importance of Perspective in the Measurement of Quality-adjusted Life Years," Medical Decision Making, , vol. 17(1), pages 33-41, February.
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