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Accounting for plasma levels below detection limits in a one-compartment zero-order absorption pharmacokinetics model

Author

Listed:
  • Alan Hutson
  • Lauren Fishbein
  • Patricia O'Brien
  • Peter Stacpoole

Abstract

We provide a simple method for fitting a one-compartment, zero-order absorption pharmacokinetics model in the presence of observations below the detection limit. This method may be extended to more complex pharmacokinetics models. We demonstrate, using a small simulation study, that the method provides accurate parameter estimates over a range of detection limits and we compare it to an ad hoc midpoint method. An applied example is provided from a pharmacokinetic investigation of a nicotine nasal spray.

Suggested Citation

  • Alan Hutson & Lauren Fishbein & Patricia O'Brien & Peter Stacpoole, 2002. "Accounting for plasma levels below detection limits in a one-compartment zero-order absorption pharmacokinetics model," Journal of Applied Statistics, Taylor & Francis Journals, vol. 29(8), pages 1181-1190.
    • Handle: RePEc:taf:japsta:v:29:y:2002:i:8:p:1181-1190
    DOI: 10.1080/0266476022000011256
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    References listed on IDEAS

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    1. James Tobin, 1956. "Estimation of Relationships for Limited Dependent Variables," Cowles Foundation Discussion Papers 3R, Cowles Foundation for Research in Economics, Yale University.
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