IDEAS home Printed from https://ideas.repec.org/a/spr/testjl/v22y2013i3p534-547.html
   My bibliography  Save this article

Penalized likelihood ratio tests for repeated measurement models

Author

Listed:
  • Christian Ritz

Abstract

In this paper, we propose a novel test procedure for repeated measurements based on the penalized likelihood ratio (PLR). The procedure provides an alternative to the standard likelihood ratio tests for evaluating null hypotheses concerning the correlation structure of repeated measurements. PLR tests are specifically designed for nonstandard test situations where non-identifiability of a nuisance parameter occurs under the null hypothesis. The idea is to penalize the estimation close to the boundary of the domain of the nuisance parameter and thereby eliminate the non-identifiability. We show that the asymptotic distribution of the PLR test is a 50:50 mixture of chi-square distributions with 0 and 1 degrees of freedom. Simulation studies indicate that the asymptotic distribution of the PLR test provides a good approximation, even for fairly small data sets (10–20 subjects). A sensitivity analysis with a real data example highlights the strengths and weaknesses of the test procedure. Copyright Sociedad de Estadística e Investigación Operativa 2013

Suggested Citation

  • Christian Ritz, 2013. "Penalized likelihood ratio tests for repeated measurement models," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 22(3), pages 534-547, September.
    • Handle: RePEc:spr:testjl:v:22:y:2013:i:3:p:534-547
    DOI: 10.1007/s11749-013-0324-8
    as

    Download full text from publisher

    File URL: http://hdl.handle.net/10.1007/s11749-013-0324-8
    Download Restriction: Access to full text is restricted to subscribers.
    File URL: https://libkey.io/10.1007/s11749-013-0324-8?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Filipe Marques & Carlos Coelho & Barry Arnold, 2011. "A general near-exact distribution theory for the most common likelihood ratio test statistics used in Multivariate Analysis," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 20(1), pages 180-203, May.
    2. Chong-Zhi Di & Kung-Yee Liang, 2011. "Likelihood Ratio Testing for Admixture Models with Application to Genetic Linkage Analysis," Biometrics, The International Biometric Society, vol. 67(4), pages 1249-1259, December.
    3. P. Li & J. Chen & P. Marriott, 2009. "Non-finite Fisher information and homogeneity: an EM approach," Biometrika, Biometrika Trust, vol. 96(2), pages 411-426.
    4. Hanfeng Chen & Jiahua Chen & John D. Kalbfleisch, 2001. "A modified likelihood ratio test for homogeneity in finite mixture models," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 63(1), pages 19-29.
    5. Geert Verbeke & Geert Molenberghs, 2003. "The Use of Score Tests for Inference on Variance Components," Biometrics, The International Biometric Society, vol. 59(2), pages 254-262, June.
    6. Christian Ritz & Ib M. Skovgaard, 2005. "Likelihood ratio tests in curved exponential families with nuisance parameters present only under the alternative," Biometrika, Biometrika Trust, vol. 92(3), pages 507-517, September.
    7. Jin Zhang & Keming Yu, 2006. "The null distribution of the likelihood-ratio test for one or two outliers in a normal sample," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 15(1), pages 141-150, June.
    8. Ciprian M. Crainiceanu & David Ruppert, 2004. "Likelihood ratio tests in linear mixed models with one variance component," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 66(1), pages 165-185, February.
    9. Hanfeng Chen & Jiahua Chen & John D. Kalbfleisch, 2004. "Testing for a finite mixture model with two components," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 66(1), pages 95-115, February.
    10. Yong Chen & Kung-Yee Liang, 2010. "On the asymptotic behaviour of the pseudolikelihood ratio test statistic with boundary problems," Biometrika, Biometrika Trust, vol. 97(3), pages 603-620.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Chuan Hong & Yang Ning & Shuang Wang & Hao Wu & Raymond J. Carroll & Yong Chen, 2017. "PLEMT: A Novel Pseudolikelihood-Based EM Test for Homogeneity in Generalized Exponential Tilt Mixture Models," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 112(520), pages 1393-1404, October.
    2. Yang Ning & Yong Chen, 2015. "A Class of Pseudolikelihood Ratio Tests for Homogeneity in Exponential Tilt Mixture Models," Scandinavian Journal of Statistics, Danish Society for Theoretical Statistics;Finnish Statistical Society;Norwegian Statistical Association;Swedish Statistical Association, vol. 42(2), pages 504-517, June.
    3. Wei‐Wen Hsu & David Todem & KyungMann Kim, 2016. "A sup‐score test for the cure fraction in mixture models for long‐term survivors," Biometrics, The International Biometric Society, vol. 72(4), pages 1348-1357, December.
    4. Hiroyuki Kasahara & Katsumi Shimotsu, 2017. "Testing the Order of Multivariate Normal Mixture Models," CIRJE F-Series CIRJE-F-1044, CIRJE, Faculty of Economics, University of Tokyo.
    5. Benjamin R. Saville & Amy H. Herring, 2009. "Testing Random Effects in the Linear Mixed Model Using Approximate Bayes Factors," Biometrics, The International Biometric Society, vol. 65(2), pages 369-376, June.
    6. Zhu, Hongtu & Zhang, Heping, 2006. "Asymptotics for estimation and testing procedures under loss of identifiability," Journal of Multivariate Analysis, Elsevier, vol. 97(1), pages 19-45, January.
    7. Long Qu & Tobias Guennel & Scott L. Marshall, 2013. "Linear Score Tests for Variance Components in Linear Mixed Models and Applications to Genetic Association Studies," Biometrics, The International Biometric Society, vol. 69(4), pages 883-892, December.
    8. Andrew Sweeting, 2009. "The strategic timing incentives of commercial radio stations: An empirical analysis using multiple equilibria," RAND Journal of Economics, RAND Corporation, vol. 40(4), pages 710-742, December.
    9. Kasahara Hiroyuki & Shimotsu Katsumi, 2012. "Testing the Number of Components in Finite Mixture Models," Global COE Hi-Stat Discussion Paper Series gd12-259, Institute of Economic Research, Hitotsubashi University.
    10. Hiroyuki Kasahara & Tatsuyoshi Okimoto & Katsumi Shimotsu, 2014. "Modified Quasi-Likelihood Ratio Test for Regime Switching," The Japanese Economic Review, Japanese Economic Association, vol. 65(1), pages 25-41, March.
    11. Satkartar K. Kinney & David B. Dunson, 2007. "Fixed and Random Effects Selection in Linear and Logistic Models," Biometrics, The International Biometric Society, vol. 63(3), pages 690-698, September.
    12. Gumedze, Freedom N. & Welham, Sue J. & Gogel, Beverley J. & Thompson, Robin, 2010. "A variance shift model for detection of outliers in the linear mixed model," Computational Statistics & Data Analysis, Elsevier, vol. 54(9), pages 2128-2144, September.
    13. Jiaying Gu & Roger Koenker & Stanislav Volgushev, 2017. "Testing for homogeneity in mixture models," CeMMAP working papers CWP39/17, Centre for Microdata Methods and Practice, Institute for Fiscal Studies.
    14. Rui Duan & Yang Ning & Shuang Wang & Bruce G. Lindsay & Raymond J. Carroll & Yong Chen, 2020. "A fast score test for generalized mixture models," Biometrics, The International Biometric Society, vol. 76(3), pages 811-820, September.
    15. Garrett M. Fitzmaurice & Stuart R. Lipsitz & Joseph G. Ibrahim, 2007. "A Note on Permutation Tests for Variance Components in Multilevel Generalized Linear Mixed Models," Biometrics, The International Biometric Society, vol. 63(3), pages 942-946, September.
    16. Zaixing Li & Lixing Zhu, 2010. "On Variance Components in Semiparametric Mixed Models for Longitudinal Data," Scandinavian Journal of Statistics, Danish Society for Theoretical Statistics;Finnish Statistical Society;Norwegian Statistical Association;Swedish Statistical Association, vol. 37(3), pages 442-457, September.
    17. Juvêncio Nobre & Julio Singer & Pranab Sen, 2013. "U-tests for variance components in linear mixed models," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 22(4), pages 580-605, November.
    18. Cui, Yin & Fu, Yuejiao & Hussein, Abdulkadir, 2009. "Group sequential testing of homogeneity in genetic linkage analysis," Computational Statistics & Data Analysis, Elsevier, vol. 53(10), pages 3630-3639, August.
    19. Ana-Maria Staicu & Yingxing Li & Ciprian M. Crainiceanu & David Ruppert, 2014. "Likelihood Ratio Tests for Dependent Data with Applications to Longitudinal and Functional Data Analysis," Scandinavian Journal of Statistics, Danish Society for Theoretical Statistics;Finnish Statistical Society;Norwegian Statistical Association;Swedish Statistical Association, vol. 41(4), pages 932-949, December.
    20. Oliver E. Lee & Thomas M. Braun, 2012. "Permutation Tests for Random Effects in Linear Mixed Models," Biometrics, The International Biometric Society, vol. 68(2), pages 486-493, June.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:spr:testjl:v:22:y:2013:i:3:p:534-547. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.springer.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.