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Cost-effectiveness analysis of anti-influenza drugs in adult outpatient settings in Japan

Author

Listed:
  • Naoto Nakagawa

    (Ohu University)

  • Satoru Harada

    (Ohu University)

  • Kiyohito Morita

    (Ohu University)

  • Akimasa Morikawa

    (Pharma Brie)

  • Yukinori Kanazawa

    (Pharma Brie)

  • Leanne Lai

    (Nova Southeastern University)

Abstract

The loss of productivity due to influenza virus (flu) infections (3 to 5 million cases globally), which can sometimes amount to as much as five working days, is a major socioeconomic issue. This study compares baloxavir marboxil’s cost-effectiveness with that of oseltamivir for influenza treatment in adult outpatient settings in Japan from the healthcare-payer perspective. A decision tree model was constructed with probabilities from CAPSTONE 1 for low-risk patients and CAPSTONE 2 for high-risk patients. Direct costs included medical costs and drug prices. Medical costs were obtained from the Japanese Medical fee index (2019 version). Effectiveness outcomes (quality-adjusted life-year [QALY]) were measured using the EQ-5D-5L questionnaire for adult patients who previously experienced flu infection. The time horizon was 14 days. Deterministic and probabilistic sensitivity analyses were performed to examine the robustness of the results. The base case analysis revealed oseltamivir dominated baloxavir marboxil for low-risk patients. However, the incremental cost-effectiveness ratio (ICER) for high-risk patients with body weight

Suggested Citation

  • Naoto Nakagawa & Satoru Harada & Kiyohito Morita & Akimasa Morikawa & Yukinori Kanazawa & Leanne Lai, 2023. "Cost-effectiveness analysis of anti-influenza drugs in adult outpatient settings in Japan," SN Business & Economics, Springer, vol. 3(12), pages 1-16, December.
    • Handle: RePEc:spr:snbeco:v:3:y:2023:i:12:d:10.1007_s43546-023-00580-8
    DOI: 10.1007/s43546-023-00580-8
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    References listed on IDEAS

    as
    1. Martin Keech & Paul Beardsworth, 2008. "The Impact of Influenza on Working Days Lost," PharmacoEconomics, Springer, vol. 26(11), pages 911-924, November.
    2. Takeru Shiroiwa & Yoon‐Kyoung Sung & Takashi Fukuda & Hui‐Chu Lang & Sang‐Cheol Bae & Kiichiro Tsutani, 2010. "International survey on willingness‐to‐pay (WTP) for one additional QALY gained: what is the threshold of cost effectiveness?," Health Economics, John Wiley & Sons, Ltd., vol. 19(4), pages 422-437, April.
    Full references (including those not matched with items on IDEAS)

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    More about this item

    Keywords

    Baloxavir marboxil; Influenza virus infection; Cost-effectiveness analysis; QALY; Japan;
    All these keywords.

    JEL classification:

    • I19 - Health, Education, and Welfare - - Health - - - Other

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