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Fitting Nonlinear Ordinary Differential Equation Models with Random Effects and Unknown Initial Conditions Using the Stochastic Approximation Expectation–Maximization (SAEM) Algorithm

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  • Sy-Miin Chow
  • Zhaohua Lu
  • Andrew Sherwood
  • Hongtu Zhu

Abstract

The past decade has evidenced the increased prevalence of irregularly spaced longitudinal data in social sciences. Clearly lacking, however, are modeling tools that allow researchers to fit dynamic models to irregularly spaced data, particularly data that show nonlinearity and heterogeneity in dynamical structures. We consider the issue of fitting multivariate nonlinear differential equation models with random effects and unknown initial conditions to irregularly spaced data. A stochastic approximation expectation–maximization algorithm is proposed and its performance is evaluated using a benchmark nonlinear dynamical systems model, namely, the Van der Pol oscillator equations. The empirical utility of the proposed technique is illustrated using a set of 24-h ambulatory cardiovascular data from 168 men and women. Pertinent methodological challenges and unresolved issues are discussed. Copyright The Psychometric Society 2016

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  • Sy-Miin Chow & Zhaohua Lu & Andrew Sherwood & Hongtu Zhu, 2016. "Fitting Nonlinear Ordinary Differential Equation Models with Random Effects and Unknown Initial Conditions Using the Stochastic Approximation Expectation–Maximization (SAEM) Algorithm," Psychometrika, Springer;The Psychometric Society, vol. 81(1), pages 102-134, March.
  • Handle: RePEc:spr:psycho:v:81:y:2016:i:1:p:102-134
    DOI: 10.1007/s11336-014-9431-z
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    2. Sy-Miin Chow & Lu Ou & Arridhana Ciptadi & Emily B. Prince & Dongjun You & Michael D. Hunter & James M. Rehg & Agata Rozga & Daniel S. Messinger, 2018. "Representing Sudden Shifts in Intensive Dyadic Interaction Data Using Differential Equation Models with Regime Switching," Psychometrika, Springer;The Psychometric Society, vol. 83(2), pages 476-510, June.
    3. Zhao-Hua Lu & Sy-Miin Chow & Nilam Ram & Pamela M. Cole, 2019. "Zero-Inflated Regime-Switching Stochastic Differential Equation Models for Highly Unbalanced Multivariate, Multi-Subject Time-Series Data," Psychometrika, Springer;The Psychometric Society, vol. 84(2), pages 611-645, June.
    4. Zhang, Siliang & Chen, Yunxiao, 2022. "Computation for latent variable model estimation: a unified stochastic proximal framework," LSE Research Online Documents on Economics 114489, London School of Economics and Political Science, LSE Library.

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