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Validity and responsiveness of EQ-5D-Y in children with haematological malignancies and their caregivers

Author

Listed:
  • Wenjing Zhou

    (Shanghai Jiaotong University
    Erasmus Medical Centre)

  • Anle Shen

    (Shanghai Jiaotong University)

  • Zhihao Yang

    (Guizhou Medical University)

  • Pei Wang

    (Fudan University)

  • Bin Wu

    (Shanghai Jiaotong University)

  • Michael Herdman

    (National University of Singapore)

  • Jan Busschbach

    (Erasmus Medical Centre)

  • Nan Luo

    (National University of Singapore)

Abstract

The psychometric properties of the EQ-5D-Y have not been widely tested in severely ill children. The aim of this study was to assess and compare the validity and responsiveness of the EQ-5D-Y-3L and EQ-5D-Y-5L in paediatric inpatients with haematological malignancies and caregivers. Respondents completed the interviewer-administered self-complete or proxy version of the EQ-5D-Y-3L and EQ-5D-Y-5L and an overall health assessment twice on different days. Known-groups validity was assessed by comparing patients who differed in overall health and Eastern Cooperative Oncology Group (ECOG) performance. Responsiveness to worsened health was assessed using standardised effect size (SES) for patients with worsened ECOG grade, self-reported rating, or chemotherapy initiation. Ninety-six dyads completed the baseline questionnaires. A smaller proportion of patients reported “no problems” on the EQ-5D-Y-5L compared to EQ-5D-Y-3L for most of the five dimensions. Patients in poor health reported more problems in all dimensions and had higher EQ-5D-Y-5L level sum score, lower EQ VAS and EQ-5D-Y-3L index scores (Cohen’s d ES: 0.32–1.38 for patients; 0.50–2.05 for caregivers). There was a mild to good responsiveness to worsened health condition based on ECOG (SES: 0.14–0.61 for patients; 0.40–0.96 for caregivers), suggesting the proxy version was slightly responsive than the self-complete version of both instruments. The results demonstrated validity and responsiveness for both the self-complete and proxy versions of the EQ-5D-Y-3L and EQ-5D-Y-5L. The proxy and 5-level versions of the instrument were more sensitive than the self-complete and 3-level versions in this patient group.

Suggested Citation

  • Wenjing Zhou & Anle Shen & Zhihao Yang & Pei Wang & Bin Wu & Michael Herdman & Jan Busschbach & Nan Luo, 2024. "Validity and responsiveness of EQ-5D-Y in children with haematological malignancies and their caregivers," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 25(8), pages 1361-1370, November.
    • Handle: RePEc:spr:eujhec:v:25:y:2024:i:8:d:10.1007_s10198-024-01669-z
    DOI: 10.1007/s10198-024-01669-z
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    References listed on IDEAS

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    1. Nancy J. Devlin & Richard Brooks, 2017. "EQ-5D and the EuroQol Group: Past, Present and Future," Applied Health Economics and Health Policy, Springer, vol. 15(2), pages 127-137, April.
    2. Mathieu F. Janssen & Gouke J. Bonsel & Nan Luo, 2018. "Is EQ-5D-5L Better Than EQ-5D-3L? A Head-to-Head Comparison of Descriptive Systems and Value Sets from Seven Countries," PharmacoEconomics, Springer, vol. 36(6), pages 675-697, June.
    3. Wang Pei & Sun Yue & Yang Zhi-Hao & Zhang Ruo-Yu & Wu Bin & Luo Nan, 2021. "Testing measurement properties of two EQ-5D youth versions and KIDSCREEN-10 in China," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 22(7), pages 1083-1093, September.
    4. Jiaer Lin & Carlos King Ho Wong & Jason Pui Yin Cheung & Prudence Wing Hang Cheung & Nan Luo, 2022. "Psychometric performance of proxy-reported EQ-5D youth version 5-level (EQ-5D-Y-5L) in comparison with three-level (EQ-5D-Y-3L) in children and adolescents with scoliosis," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 23(8), pages 1383-1395, November.
    5. Rachel Lee-Yin Tan & Sonia Zhi Yi Soh & Le Ann Chen & Michael Herdman & Nan Luo, 2023. "Psychometric Properties of Generic Preference-Weighted Measures for Children and Adolescents: A Systematic Review," PharmacoEconomics, Springer, vol. 41(2), pages 155-174, February.
    6. Ines Buchholz & Mathieu F. Janssen & Thomas Kohlmann & You-Shan Feng, 2018. "A Systematic Review of Studies Comparing the Measurement Properties of the Three-Level and Five-Level Versions of the EQ-5D," PharmacoEconomics, Springer, vol. 36(6), pages 645-661, June.
    7. Wenjing Zhou & Anle Shen & Zhihao Yang & Pei Wang & Bin Wu & Michael Herdman & Nan Luo, 2021. "Patient-caregiver agreement and test–retest reliability of the EQ-5D-Y-3L and EQ-5D-Y-5L in paediatric patients with haematological malignancies," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 22(7), pages 1103-1113, September.
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