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Community Blood Supply Model: Development of a New Model to Assess the Safety, Sufficiency, and Cost of the Blood Supply

Author

Listed:
  • Brian Custer

    (Blood Systems Research Institute, 270 Masonic Avenue, San Francisco, CA 94118-4417; Pharmaceutical Outcomes Research and Policy Program, University of Washington, Seattle; Blood Systems Research Institute, San Francisco, Californiabcuster@bloodsystems.org.)

  • Eric S. Johnson
  • Sean D. Sullivan
  • Tom K. Hazlet
  • Scott D. Ramsey

    (Pharmaceutical Outcomes Research and Policy Program, University of Washington, Seattle)

  • Edward L. Murphy
  • Michael P. Busch

    (Blood Systems Research Institute, San Francisco, California; and University of California, San Francisco, Department of Laboratory Medicine)

Abstract

Background. Through a combination of predonation donor screening and donated unit testing, the blood supply is safer than ever. However, as a result of increasingly stringent screening measures, one of the greatest threats may be an insufficient supply. The balance between safety and adequacy of the blood supply has not received enough attention. Study Design and Methods. The authors developed a model to allow for empirical investigation of the determinants of a safe and sufficient supply. The model is a cohort simulation of allogeneic whole-blood donation, with the population of presenting donors stratified into 8 age and gender groups because the probability of donor and donation deferral varies by these characteristics. Parameters are estimated from year 2000 Blood Centers of Pacific (BCP) data. The model includes cost parameters, which were estimated using BCP expenditure data. The main outcomes are the number of transfusable units of blood and the unit cost of procurement. Results. The model tracks the production of a supply of blood, highlighting the influence of demographic characteristics, predonation deferral, underweight collection of blood units, and associated costs. The authors sought to establish model validity by showing that modeled results closely mimic the outcomes and costs observed by blood bank administrators. Conclusion. The model was developed to evaluate blood safety and policy decisions; it can be used to assess the impact of predonation deferrals, such as expanded European travel deferral for variant Creutzfeldt-Jakob disease, or the impact of new testing strategies, such as nucleic acid testing for West Nile virus.

Suggested Citation

  • Brian Custer & Eric S. Johnson & Sean D. Sullivan & Tom K. Hazlet & Scott D. Ramsey & Edward L. Murphy & Michael P. Busch, 2005. "Community Blood Supply Model: Development of a New Model to Assess the Safety, Sufficiency, and Cost of the Blood Supply," Medical Decision Making, , vol. 25(5), pages 571-582, September.
    • Handle: RePEc:sae:medema:v:25:y:2005:i:5:p:571-582
    DOI: 10.1177/0272989X05280557
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    Citations

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    Cited by:

    1. Gunpinar, Serkan & Centeno, Grisselle, 2016. "An integer programming approach to the bloodmobile routing problem," Transportation Research Part E: Logistics and Transportation Review, Elsevier, vol. 86(C), pages 94-115.
    2. W. Alton Russell & Brian Custer & Margaret L. Brandeau, 2021. "Optimal portfolios of blood safety interventions: test, defer or modify?," Health Care Management Science, Springer, vol. 24(3), pages 551-568, September.
    3. Marketta Veihola & Pekka Aroviita & Riitta Kekomäki & Miika Linna & Harri Sintonen, 2008. "Discarded cellular components and the technical efficiency of component preparation," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 9(4), pages 325-331, November.
    4. Bruno, Giuseppe & Diglio, Antonio & Piccolo, Carmela & Cannavacciuolo, Lorella, 2019. "Territorial reorganization of regional blood management systems: Evidences from an Italian case study," Omega, Elsevier, vol. 89(C), pages 54-70.
    5. Katsaliaki, Korina, 2008. "Cost-effective practices in the blood service sector," Health Policy, Elsevier, vol. 86(2-3), pages 276-287, May.
    6. Ming-Wen An & Nicholas G Reich & Stephen O Crawford & Ron Brookmeyer & Thomas A Louis & Kenrad E Nelson, 2011. "A Stochastic Simulator of a Blood Product Donation Environment with Demand Spikes and Supply Shocks," PLOS ONE, Public Library of Science, vol. 6(7), pages 1-9, July.
    7. Beliën, Jeroen & Forcé, Hein, 2012. "Supply chain management of blood products: A literature review," European Journal of Operational Research, Elsevier, vol. 217(1), pages 1-16.

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