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Selecting the best machine learning algorithm to support the diagnosis of Non-Alcoholic Fatty Liver Disease: A meta learner study

Author

Listed:
  • Paolo Sorino
  • Maria Gabriella Caruso
  • Giovanni Misciagna
  • Caterina Bonfiglio
  • Angelo Campanella
  • Antonella Mirizzi
  • Isabella Franco
  • Antonella Bianco
  • Claudia Buongiorno
  • Rosalba Liuzzi
  • Anna Maria Cisternino
  • Maria Notarnicola
  • Marisa Chiloiro
  • Giovanni Pascoschi
  • Alberto Rubén Osella
  • MICOL Group

Abstract

Background & aims: Liver ultrasound scan (US) use in diagnosing Non-Alcoholic Fatty Liver Disease (NAFLD) causes costs and waiting lists overloads. We aimed to compare various Machine learning algorithms with a Meta learner approach to find the best of these as a predictor of NAFLD. Methods: The study included 2970 subjects, 2920 constituting the training set and 50, randomly selected, used in the test phase, performing cross-validation. The best predictors were combined to create three models: 1) FLI plus GLUCOSE plus SEX plus AGE, 2) AVI plus GLUCOSE plus GGT plus SEX plus AGE, 3) BRI plus GLUCOSE plus GGT plus SEX plus AGE. Eight machine learning algorithms were trained with the predictors of each of the three models created. For these algorithms, the percent accuracy, variance and percent weight were compared. Results: The SVM algorithm performed better with all models. Model 1 had 68% accuracy, with 1% variance and an algorithm weight of 27.35; Model 2 had 68% accuracy, with 1% variance and an algorithm weight of 33.62 and Model 3 had 77% accuracy, with 1% variance and an algorithm weight of 34.70. Model 2 was the most performing, composed of AVI plus GLUCOSE plus GGT plus SEX plus AGE, despite a lower percentage of accuracy. Conclusion: A Machine Learning approach can support NAFLD diagnosis and reduce health costs. The SVM algorithm is easy to apply and the necessary parameters are easily retrieved in databases.

Suggested Citation

  • Paolo Sorino & Maria Gabriella Caruso & Giovanni Misciagna & Caterina Bonfiglio & Angelo Campanella & Antonella Mirizzi & Isabella Franco & Antonella Bianco & Claudia Buongiorno & Rosalba Liuzzi & Ann, 2020. "Selecting the best machine learning algorithm to support the diagnosis of Non-Alcoholic Fatty Liver Disease: A meta learner study," PLOS ONE, Public Library of Science, vol. 15(10), pages 1-15, October.
    • Handle: RePEc:plo:pone00:0240867
    DOI: 10.1371/journal.pone.0240867
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    References listed on IDEAS

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    1. Karatzoglou, Alexandros & Meyer, David & Hornik, Kurt, 2006. "Support Vector Machines in R," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 15(i09).
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