IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0232245.html

Cost-effectiveness of psychological treatments for post-traumatic stress disorder in adults

Author

Listed:
  • Ifigeneia Mavranezouli
  • Odette Megnin-Viggars
  • Nick Grey
  • Gita Bhutani
  • Jonathan Leach
  • Caitlin Daly
  • Sofia Dias
  • Nicky J Welton
  • Cornelius Katona
  • Sharif El-Leithy
  • Neil Greenberg
  • Sarah Stockton
  • Stephen Pilling

Abstract

Background: Post-traumatic stress disorder (PTSD) is a severe and disabling condition that may lead to functional impairment and reduced productivity. Psychological interventions have been shown to be effective in its management. The objective of this study was to assess the cost-effectiveness of a range of interventions for adults with PTSD. Methods: A decision-analytic model was constructed to compare costs and quality-adjusted life-years (QALYs) of 10 interventions and no treatment for adults with PTSD, from the perspective of the National Health Service and personal social services in England. Effectiveness data were derived from a systematic review and network meta-analysis. Other model input parameters were based on published sources, supplemented by expert opinion. Results: Eye movement desensitisation and reprocessing (EMDR) appeared to be the most cost-effective intervention for adults with PTSD (with a probability of 0.34 amongst the 11 evaluated options at a cost-effectiveness threshold of £20,000/QALY), followed by combined somatic/cognitive therapies, self-help with support, psychoeducation, selective serotonin reuptake inhibitors (SSRIs), trauma-focused cognitive behavioural therapy (TF-CBT), self-help without support, non-TF-CBT and combined TF-CBT/SSRIs. Counselling appeared to be less cost-effective than no treatment. TF-CBT had the largest evidence base. Conclusions: A number of interventions appear to be cost-effective for the management of PTSD in adults. EMDR appears to be the most cost-effective amongst them. TF-CBT has the largest evidence base. There remains a need for well-conducted studies that examine the long-term clinical and cost-effectiveness of a range of treatments for adults with PTSD.

Suggested Citation

  • Ifigeneia Mavranezouli & Odette Megnin-Viggars & Nick Grey & Gita Bhutani & Jonathan Leach & Caitlin Daly & Sofia Dias & Nicky J Welton & Cornelius Katona & Sharif El-Leithy & Neil Greenberg & Sarah S, 2020. "Cost-effectiveness of psychological treatments for post-traumatic stress disorder in adults," PLOS ONE, Public Library of Science, vol. 15(4), pages 1-22, April.
    • Handle: RePEc:plo:pone00:0232245
    DOI: 10.1371/journal.pone.0232245
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232245
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0232245&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0232245?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Briggs, Andrew & Sculpher, Mark & Claxton, Karl, 2006. "Decision Modelling for Health Economic Evaluation," OUP Catalogue, Oxford University Press, number 9780198526629.
    2. Brazier, John & Roberts, Jennifer & Deverill, Mark, 2002. "The estimation of a preference-based measure of health from the SF-36," Journal of Health Economics, Elsevier, vol. 21(2), pages 271-292, March.
    3. Walters, SJ & Brazier, JE, 2002. "Sample sizes for the SF-6D preference based measure of health from the SF-36: a practical guide," MPRA Paper 29742, University Library of Munich, Germany.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Filip Stanicic & Vladimir Zah & Dimitrije Grbic & Debra De Angelo, 2024. "Cost-effectiveness of midomafetamine-assisted therapy (MDMA-AT) in chronic and treatment-resistant post-traumatic stress disorder of moderate or higher severity: A health-economic model," PLOS ONE, Public Library of Science, vol. 19(11), pages 1-15, November.
    2. Amos Nnaemeka Amedu, 2023. "Assessment of Psychological Treatments and Its Affordability Among Students with Post-Traumatic Stress Disorder: A Scoping Review," International Journal of Home Economics, Hospitality and Allied Research, Department of Home Economics & Hospitality Management Education, University of Nigeria, Nsukka, vol. 2(2), pages 248-264.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Lisa R. Ulrich & Juliana J. Petersen & Karola Mergenthal & Andrea Berghold & Gudrun Pregartner & Rolf Holle & Andrea Siebenhofer, 2019. "Cost-effectiveness analysis of case management for optimized antithrombotic treatment in German general practices compared to usual care – results from the PICANT trial," Health Economics Review, Springer, vol. 9(1), pages 1-10, December.
    2. David McDaid & A-La Park, 2021. "Modelling the Economic Impact of Reducing Loneliness in Community Dwelling Older People in England," IJERPH, MDPI, vol. 18(4), pages 1-16, February.
    3. Leyla Mohseninejad & Talitha Feenstra & Henriëtte Horst & Hèlen Woutersen-Koch & Erik Buskens, 2013. "Targeted screening for Coeliac Disease among irritable bowel syndrome patients: analysis of cost-effectiveness and value of information," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 14(6), pages 947-957, December.
    4. Nicholas Graves & Adrian G Barnett & Kate A Halton & Jacob L Veerman & Elisabeth Winkler & Neville Owen & Marina M Reeves & Alison Marshall & Elizabeth Eakin, 2009. "Cost-Effectiveness of a Telephone-Delivered Intervention for Physical Activity and Diet," PLOS ONE, Public Library of Science, vol. 4(9), pages 1-8, September.
    5. Brendan Mulhern & Richard Norman & Deborah J. Street & Rosalie Viney, 2019. "One Method, Many Methodological Choices: A Structured Review of Discrete-Choice Experiments for Health State Valuation," PharmacoEconomics, Springer, vol. 37(1), pages 29-43, January.
    6. Colin Green & David A Richards & Jacqueline J Hill & Linda Gask & Karina Lovell & Carolyn Chew-Graham & Peter Bower & John Cape & Stephen Pilling & Ricardo Araya & David Kessler & J Martin Bland & Sim, 2014. "Cost-Effectiveness of Collaborative Care for Depression in UK Primary Care: Economic Evaluation of a Randomised Controlled Trial (CADET)," PLOS ONE, Public Library of Science, vol. 9(8), pages 1-12, August.
    7. Xinyu Qian & Rachel Lee-Yin Tan & Ling-Hsiang Chuang & Nan Luo, 2020. "Measurement Properties of Commonly Used Generic Preference-Based Measures in East and South-East Asia: A Systematic Review," PharmacoEconomics, Springer, vol. 38(2), pages 159-170, February.
    8. Cate Bailey & Kim Dalziel & Renee Jones & Harriet Hiscock & Nancy J. Devlin & Tessa Peasgood, 2024. "The Validity of the EuroQol Health and Wellbeing Short Version (EQ-HWB-S) Instrument in Parents of Children With and Without Health Conditions," PharmacoEconomics, Springer, vol. 42(1), pages 163-179, June.
    9. McDaid, David & Park, A-La, 2021. "Modelling the economic impact of reducing loneliness in community dwelling older people in England," LSE Research Online Documents on Economics 108594, London School of Economics and Political Science, LSE Library.
    10. Matthijs M. Versteegh & Annemieke Leunis & Jolanda J. Luime & Mike Boggild & Carin A. Uyl-de Groot & Elly A. Stolk, 2012. "Mapping QLQ-C30, HAQ, and MSIS-29 on EQ-5D," Medical Decision Making, , vol. 32(4), pages 554-568, July.
    11. Hui Shao & Shuang Yang & Vivian Fonseca & Charles Stoecker & Lizheng Shi, 2019. "Estimating Quality of Life Decrements Due to Diabetes Complications in the United States: The Health Utility Index (HUI) Diabetes Complication Equation," PharmacoEconomics, Springer, vol. 37(7), pages 921-929, July.
    12. Ifigeneia Mavranezouli & Nick Meader & John Cape & Tim Kendall, 2013. "The Cost Effectiveness of Pharmacological Treatments for Generalized Anxiety Disorder," PharmacoEconomics, Springer, vol. 31(4), pages 317-333, April.
    13. Chiranjeev Sanyal & Don Husereau, 2020. "Systematic Review of Economic Evaluations of Services Provided by Community Pharmacists," Applied Health Economics and Health Policy, Springer, vol. 18(3), pages 375-392, June.
    14. Samer A. Kharroubi & Yara Beyh & Marwa Diab El Harake & Dalia Dawoud & Donna Rowen & John Brazier, 2020. "Examining the Feasibility and Acceptability of Valuing the Arabic Version of SF-6D in a Lebanese Population," IJERPH, MDPI, vol. 17(3), pages 1-15, February.
    15. Nick Bansback & Huiying Sun & Daphne P. Guh & Xin Li & Bohdan Nosyk & Susan Griffin & Paul G. Barnett & Aslam H. Anis, 2008. "Impact of the recall period on measuring health utilities for acute events," Health Economics, John Wiley & Sons, Ltd., vol. 17(12), pages 1413-1419.
    16. Arantzazu Arrospide & Oliver Ibarrondo & Iván Castilla & Igor Larrañaga & Javier Mar, 2022. "Development and Validation of a Discrete Event Simulation Model to Evaluate the Cardiovascular Impact of Population Policies for Obesity," Medical Decision Making, , vol. 42(2), pages 241-254, February.
    17. Clarke, Philip & Erreygers, Guido, 2020. "Defining and measuring health poverty," Social Science & Medicine, Elsevier, vol. 244(C).
    18. Mark Oppe & Daniela Ortín-Sulbarán & Carlos Vila Silván & Anabel Estévez-Carrillo & Juan M. Ramos-Goñi, 2021. "Cost-effectiveness of adding Sativex® spray to spasticity care in Belgium: using bootstrapping instead of Monte Carlo simulation for probabilistic sensitivity analyses," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 22(5), pages 711-721, July.
    19. Kaitlyn Hastings & Clara Marquina & Jedidiah Morton & Dina Abushanab & Danielle Berkovic & Stella Talic & Ella Zomer & Danny Liew & Zanfina Ademi, 2022. "Projected New-Onset Cardiovascular Disease by Socioeconomic Group in Australia," PharmacoEconomics, Springer, vol. 40(4), pages 449-460, April.
    20. Michael S. Willis & Andreas Nilsson & Cheryl A. Neslusan, 2025. "A Review of Heterogeneity in Comparative Economic Analysis, with Specific Considerations for the Decentralized US Setting and Patient-Centered Care," PharmacoEconomics, Springer, vol. 43(6), pages 601-616, June.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0232245. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.