IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0227904.html
   My bibliography  Save this article

Effectiveness of intravenous lidocaine in preventing postoperative nausea and vomiting in pediatric patients: A systematic review and meta-analysis

Author

Listed:
  • Daisuke Nakajima
  • Hiromasa Kawakami
  • Takahiro Mihara
  • Hitoshi Sato
  • Takahisa Goto

Abstract

Background: Intravenous lidocaine in adults undergoing general anesthesia has been shown to reduce the incidence of postoperative nausea and vomiting (PONV). However, the anti-postoperative vomiting (POV) effect of lidocaine in pediatric patients remains unclear. We conducted a systematic review and meta-analysis with Trial Sequential Analysis to evaluate the effect of intravenous lidocaine on prevention of POV/PONV. Methods: Six databases including trial registration sites were searched. Randomized clinical trials evaluating the incidence of POV/PONV after intravenous lidocaine compared with control were included. The primary outcome was the incidence of POV within 24 hours after general anesthesia. The incidence of POV was combined as a risk ratio with 95% confidence interval using a random-effect model. We used the I2 to assess heterogeneity. We evaluated the quality of trials using the Cochrane methodology, and we assessed quality of evidence using the Grading of Recommendation Assessment, Development, and Evaluation approach. We also assessed adverse events. Results and discussion: Six trials with 849 patients were included, of whom 433 received intravenous lidocaine. Three trials evaluated the incidence of POV, and 3 evaluated the incidence of PONV. The overall incidence of POV within 24 hours after anesthesia was 45.9% in the lidocaine group and 63.4% in the control group (risk ratio, 0.73; 95% confidence interval, 0.53–1.00; I2 = 32%; p = 0.05). The incidence of PONV within 24 hours after anesthesia was 3.73% in the lidocaine group and 4.87% in the control group (RR, 0.76; 95% CI, 0.36–1.59; I2 = 0%; p = 0.47). The quality of evidence was downgraded to “very low” due to the study designs, inconsistency, imprecision, and possible publication bias. Conclusion: Our meta-analysis suggests that intravenous lidocaine infusion may reduce the incidence of POV, however, the evidence quality was “very low.” Further trials with a low risk of bias are necessary.

Suggested Citation

  • Daisuke Nakajima & Hiromasa Kawakami & Takahiro Mihara & Hitoshi Sato & Takahisa Goto, 2020. "Effectiveness of intravenous lidocaine in preventing postoperative nausea and vomiting in pediatric patients: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 15(1), pages 1-13, January.
    • Handle: RePEc:plo:pone00:0227904
    DOI: 10.1371/journal.pone.0227904
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0227904
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0227904&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0227904?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
    2. Paul T E Cusack, 2020. "On Pain," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 31(3), pages 24253-24254, October.
    3. Ejis, 2009. "Table of Contents," European Journal of Interdisciplinary Studies, Bucharest Economic Academy, issue 01, March.
    4. Pawj, 2020. "Table of Contents," Professional Agricultural Workers Journal (PAWJ), Professional Agricultural Workers Conference, vol. 6(3), January.
    5. Ejis, 2020. "Table of Contents," European Journal of Interdisciplinary Studies, Bucharest Economic Academy, issue 01, March.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Maria M. Symeonidou & Effrosyni Giama & Agis M. Papadopoulos, 2021. "Life Cycle Assessment for Supporting Dimensioning Battery Storage Systems in Micro-Grids for Residential Applications," Energies, MDPI, vol. 14(19), pages 1-16, September.
    2. Vera Z. Eichenauer & Michael Dorsc & Feicheng Wang, 2021. "Investment Screening Mechanisms: The Trend to Control Inward Foreign Investment," EconPol Policy Reports 34, ifo Institute - Leibniz Institute for Economic Research at the University of Munich.
    3. Suwit Chaisri & Noel Pabalan & Sompong Tabunhan & Phuntila Tharabenjasin & Nipaporn Sankuntaw & Chanvit Leelayuwat, 2019. "Effects of the killer immunoglobulin–like receptor (KIR) polymorphisms on HIV acquisition: A meta-analysis," PLOS ONE, Public Library of Science, vol. 14(12), pages 1-17, December.
    4. Antonio Gagliano & Francesco Nocera & Giuseppe Tina, 2020. "Performances and economic analysis of small photovoltaic–electricity energy storage system for residential applications," Energy & Environment, , vol. 31(1), pages 155-175, February.
    5. Joseph Carrello & Alison Hayes & Anagha Killedar & Amy Huben & Louise A. Baur & Stavros Petrou & Thomas Lung, 2021. "Utility Decrements Associated with Adult Overweight and Obesity in Australia: A Systematic Review and Meta-Analysis," PharmacoEconomics, Springer, vol. 39(5), pages 503-519, May.
    6. Alexander Schniedermann, 2021. "A comparison of systematic reviews and guideline-based systematic reviews in medical studies," Scientometrics, Springer;Akadémiai Kiadó, vol. 126(12), pages 9829-9846, December.
    7. Brenda Cardoso & Luiza Cunha & Adriana Leiras & Paulo Gonçalves & Hugo Yoshizaki & Irineu de Brito Junior & Frederico Pedroso, 2021. "Causal Impacts of Epidemics and Pandemics on Food Supply Chains: A Systematic Review," Sustainability, MDPI, vol. 13(17), pages 1-28, August.
    8. Bürker, Michael, 2023. ""Ist das Marketing am Ende?": Status quo und Perspektiven im Verhältnis von Marketing und Unternehmenskommunikation," PraxisWISSEN Marketing: German Journal of Marketing, AfM – Arbeitsgemeinschaft für Marketing, vol. 8(01/2023), pages 11-35.
    9. Boshen Jiao & Anirban Basu & Joshua Roth & M. Bender & Ilsa Rovira & Traci Clemons & Dalyna Quach & Scott Ramsey & Beth Devine, 2021. "The Use of Cost-Effectiveness Analysis in Sickle Cell Disease: A Critical Review of the Literature," PharmacoEconomics, Springer, vol. 39(11), pages 1225-1241, November.
    10. Asmita Paudel & Asmita Bhattarai & Pankaj Kumar Yadav, 2021. "Soil Conservation Practices In Forest Of Nepal," Journal Clean WAS (JCleanWAS), Zibeline International Publishing, vol. 5(2), pages 73-77, December.
    11. Khalid Abdullah Mulhim Al Mulhim & Mohammad Shahidul Hasan Swapan & Shahed Khan, 2022. "Critical Junctures in Sustainable Social Housing Policy Development in Saudi Arabia: A Review," Sustainability, MDPI, vol. 14(5), pages 1-19, March.
    12. Porter, Bryony & Zile, Amy & Peryer, Guy & Farquhar, Morag & Sanderson, Kristy, 2021. "The impact of providing end-of-life care during a pandemic on the mental health and wellbeing of health and social care staff: Systematic review and meta-synthesis," Social Science & Medicine, Elsevier, vol. 287(C).
    13. Feilong Zhu & Ming Zhang & Dan Wang & Qianqin Hong & Cheng Zeng & Wei Chen, 2020. "Yoga compared to non-exercise or physical therapy exercise on pain, disability, and quality of life for patients with chronic low back pain: A systematic review and meta-analysis of randomized control," PLOS ONE, Public Library of Science, vol. 15(9), pages 1-21, September.
    14. İlkay Unay-Gailhard & Mark A. Brennen, 2022. "How digital communications contribute to shaping the career paths of youth: a review study focused on farming as a career option," Agriculture and Human Values, Springer;The Agriculture, Food, & Human Values Society (AFHVS), vol. 39(4), pages 1491-1508, December.
    15. Mahin Ghafari & Vali Baigi & Zahra Cheraghi & Amin Doosti-Irani, 2016. "The Prevalence of Asymptomatic Bacteriuria in Iranian Pregnant Women: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(6), pages 1-10, June.
    16. Santos Urbina & Sofía Villatoro & Jesús Salinas, 2021. "Self-Regulated Learning and Technology-Enhanced Learning Environments in Higher Education: A Scoping Review," Sustainability, MDPI, vol. 13(13), pages 1-12, June.
    17. Nadine Desrochers & Adèle Paul‐Hus & Jen Pecoskie, 2017. "Five decades of gratitude: A meta‐synthesis of acknowledgments research," Journal of the Association for Information Science & Technology, Association for Information Science & Technology, vol. 68(12), pages 2821-2833, December.
    18. Maryono, Maryono & Killoes, Aditya Marendra & Adhikari, Rajendra & Abdul Aziz, Ammar, 2024. "Agriculture development through multi-stakeholder partnerships in developing countries: A systematic literature review," Agricultural Systems, Elsevier, vol. 213(C).
    19. Alene Sze Jing Yong & Yi Heng Lim & Mark Wing Loong Cheong & Ednin Hamzah & Siew Li Teoh, 2022. "Willingness-to-pay for cancer treatment and outcome: a systematic review," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 23(6), pages 1037-1057, August.
    20. Agnieszka A. Tubis & Katarzyna Grzybowska, 2022. "In Search of Industry 4.0 and Logistics 4.0 in Small-Medium Enterprises—A State of the Art Review," Energies, MDPI, vol. 15(22), pages 1-26, November.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0227904. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.