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Effects and cost-effectiveness of postoperative oral analgesics for additional postoperative pain relief in children and adolescents undergoing dental treatment: Health technology assessment including a systematic review

Author

Listed:
  • Henrik Berlin
  • Martina Vall
  • Elisabeth Bergenäs
  • Karin Ridell
  • Susanne Brogårdh-Roth
  • Elisabeth Lager
  • Thomas List
  • Thomas Davidson
  • Gunilla Klingberg

Abstract

Background: There is an uncertainty regarding how to optimally prevent and/or reduce pain after dental treatment on children and adolescents. Aim: To conduct a systematic review (SR) and health technology assessment (HTA) of oral analgesics administered after dental treatment to prevent postoperative pain in children and adolescents aged 3–19 years. Design: A PICO-protocol was constructed and registered in PROSPERO (CRD42017075589). Searches were conducted in PubMed, Cochrane, Scopus, Cinahl, and EMBASE, November 2018. The researchers (reading in pairs) assessed identified studies independently, according to the defined inclusion and exclusion criteria, following the PRISMA-statement. Results: 3,963 scientific papers were identified, whereof 216 read in full text. None met the inclusion criteria, leading to an empty SR. Ethical issues were identified related to the recognized knowledge gap in terms of challenges to conduct studies that are well-designed from methodological as well as ethical perspectives. Conclusions: There is no scientific support for the use or rejection of oral analgesics administered after dental treatment in order to prevent or reduce postoperative pain in children and adolescents. Thus, no guidelines can be formulated on this issue based solely on scientific evidence. Well-designed studies on how to prevent pain from developing after dental treatment in children and adolescents is urgently needed.

Suggested Citation

  • Henrik Berlin & Martina Vall & Elisabeth Bergenäs & Karin Ridell & Susanne Brogårdh-Roth & Elisabeth Lager & Thomas List & Thomas Davidson & Gunilla Klingberg, 2019. "Effects and cost-effectiveness of postoperative oral analgesics for additional postoperative pain relief in children and adolescents undergoing dental treatment: Health technology assessment including," PLOS ONE, Public Library of Science, vol. 14(12), pages 1-11, December.
    • Handle: RePEc:plo:pone00:0227027
    DOI: 10.1371/journal.pone.0227027
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    References listed on IDEAS

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    1. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
    2. Drummond, Michael F. & Sculpher, Mark J. & Claxton, Karl & Stoddart, Greg L. & Torrance, George W., 2015. "Methods for the Economic Evaluation of Health Care Programmes," OUP Catalogue, Oxford University Press, edition 4, number 9780199665884.
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