IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0202563.html
   My bibliography  Save this article

Comparison of antidiabetic drugs added to sulfonylurea monotherapy in patients with type 2 diabetes mellitus: A network meta-analysis

Author

Listed:
  • Dan Qian
  • Tiantian Zhang
  • Xiangping Tan
  • Peiying Zheng
  • Zhuoru Liang
  • Jingmei Xie
  • Jie Jiang
  • Bing Situ

Abstract

Aims: This study aimed to investigate the efficacy and safety of dual therapy comprising sulfonylurea (SU) plus antidiabetic drugs for the treatment of type 2 diabetes mellitus (T2DM). Methods: We searched the PubMed, Cochrane library, and Embase databases for randomized clinical trials (≥24 weeks) published up to December 28, 2017. Subsequently, we conducted pairwise and network meta-analyses to calculate the odds ratios (ORs) and mean differences (MDs) with 95% confidence intervals (CIs) of the outcomes. Results: The final analyses included 24 trials with a total of 10,032 patients. Compared with placebo, all treatment regimens were associated with a significantly higher risk of hypoglycemia, except the combinations of SU plus sodium-glucose co-transporter-2 inhibitor (SGLT-2i) [OR, 1.35 (95% CI: 0.81 to 2.25)] or alpha-glucosidase inhibitor (AGI) [OR, 1.16 (95% CI: 0.55 to 2.44)]. Notably, the combination of SU plus glucagon-like peptide-1 receptor agonist (GLP-1RA) was associated with the most significant increase in the risk of hypoglycemia. Furthermore, all SU-based combination regimens reduced the glycated hemoglobin (HbA1c) and fasting plasma glucose levels (FPG). However, only combinations containing SGLT-2i [MD, -1.00 kg (95% CI: -1.73 to -0.27)] and GLP-1RA [MD, -0.56 kg (95% CI: -1.10 to -0.02)] led to weight loss. Conclusions: Our findings highlight the importance of considering the risk of hypoglycemia when selecting antidiabetic drugs to be administered concomitantly with SU. Although all classes of antidiabetic drugs improved glucose control when administered in combination with SU, SGLT-2i might be the best option with respect to factors such as hypoglycemia and body weight.

Suggested Citation

  • Dan Qian & Tiantian Zhang & Xiangping Tan & Peiying Zheng & Zhuoru Liang & Jingmei Xie & Jie Jiang & Bing Situ, 2018. "Comparison of antidiabetic drugs added to sulfonylurea monotherapy in patients with type 2 diabetes mellitus: A network meta-analysis," PLOS ONE, Public Library of Science, vol. 13(8), pages 1-17, August.
  • Handle: RePEc:plo:pone00:0202563
    DOI: 10.1371/journal.pone.0202563
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202563
    Download Restriction: no

    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0202563&type=printable
    Download Restriction: no

    File URL: https://libkey.io/10.1371/journal.pone.0202563?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Tsang, Eric W. K., 2014. "Old and New," Management and Organization Review, Cambridge University Press, vol. 10(03), pages 390-390, November.
    2. Anna Chaimani & Julian P T Higgins & Dimitris Mavridis & Panagiota Spyridonos & Georgia Salanti, 2013. "Graphical Tools for Network Meta-Analysis in STATA," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-12, October.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Ali Shalizar Jalali, 2018. "Male Fertility as a Bull’s Eye for Mastocytosis," Global Journal of Reproductive Medicine, Juniper Publishers Inc., vol. 3(3), pages 58-60, February.
    2. Hui Yan & Guixiang Liu, 2021. "Fire’s Effects on Grassland Restoration and Biodiversity Conservation," Sustainability, MDPI, vol. 13(21), pages 1-15, October.
    3. Michal Plaček & Martin Schmidt & František Ochrana & Michal Půček, 2017. "Do the Selected Characteristics of Public Tenders Affect the Likelihood of Filing Petitions with the Regulators of Public Tenders?," Prague Economic Papers, Prague University of Economics and Business, vol. 2017(3), pages 317-329.
    4. Nikolov, Plamen & Adelman, Alan, 2019. "Do private household transfers to the elderly respond to public pension benefits? Evidence from rural China," The Journal of the Economics of Ageing, Elsevier, vol. 14(C).
    5. Dana Benešová & Viera Kubičková & Miroslava Prváková, 2020. "Open innovation model in the knowledge intensive business services in the Slovak Republic," Entrepreneurship and Sustainability Issues, VsI Entrepreneurship and Sustainability Center, vol. 8(2), pages 1340-1358, December.
    6. Holzmann, Robert & Alonso-García, Jennifer & Labit-Hardy, Heloise & Villegas, Andres M., 2017. "NDC Schemes and Heterogeneity in Longevity: Proposals for Redesign," IZA Discussion Papers 11193, Institute of Labor Economics (IZA).
    7. Selman, P., 2014. "Intercountry Adoption Agencies and the HCIA," ISS Working Papers - General Series 77404, International Institute of Social Studies of Erasmus University Rotterdam (ISS), The Hague.
    8. Martinho, Vítor João Pereira Domingues, 2019. "Historical records of wine: Highlighting the old wine world," EconStor Preprints 193461, ZBW - Leibniz Information Centre for Economics.
    9. Gabriella Garbarino & Giovanni Pampararo & Thanh Khoa Phung & Paola Riani & Guido Busca, 2020. "Heterogeneous Catalysis in (Bio)Ethanol Conversion to Chemicals and Fuels: Thermodynamics, Catalysis, Reaction Paths, Mechanisms and Product Selectivities," Energies, MDPI, vol. 13(14), pages 1-19, July.
    10. Zhongcheng Yan & Feng Wei & Xin Deng & Chuan Li & Qiang He & Yanbin Qi, 2022. "Feminization of Agriculture: Do Female Farmers Have Higher Expectations for the Value of Their Farmland?—Empirical Evidence from China," Agriculture, MDPI, vol. 12(1), pages 1-22, January.
    11. Hélène Laurell & Leona Achtenhagen & Svante Andersson, 2017. "The changing role of network ties and critical capabilities in an international new venture’s early development," International Entrepreneurship and Management Journal, Springer, vol. 13(1), pages 113-140, March.
    12. Trine Filges & Anu Siren & Torben Fridberg & Bjørn C. V. Nielsen, 2020. "Voluntary work for the physical and mental health of older volunteers: A systematic review," Campbell Systematic Reviews, John Wiley & Sons, vol. 16(4), December.
    13. Konstantinos Katsanos & Panagiotis Kitrou & Stavros Spiliopoulos & Ioannis Maroulis & Theodore Petsas & Dimitris Karnabatidis, 2017. "Comparative effectiveness of different transarterial embolization therapies alone or in combination with local ablative or adjuvant systemic treatments for unresectable hepatocellular carcinoma: A net," PLOS ONE, Public Library of Science, vol. 12(9), pages 1-31, September.
    14. Alexandru-Ionuţ Petrişor & Walid Hamma & Huu Duy Nguyen & Giovanni Randazzo & Anselme Muzirafuti & Mari-Isabella Stan & Van Truong Tran & Roxana Aştefănoaiei & Quang-Thanh Bui & Dragoş-Florian Vintilă, 2020. "Degradation of Coastlines under the Pressure of Urbanization and Tourism: Evidence on the Change of Land Systems from Europe, Asia and Africa," Land, MDPI, vol. 9(8), pages 1-43, August.
    15. repec:ers:journl:v:special_issue:y:2018:i:1:p:466-478 is not listed on IDEAS
    16. Sellami Sana & Verhaest Dieter & Nonneman Walter & Van Trier Walter, 2017. "The Impact of Educational Mismatches on Wages: The Influence of Measurement Error and Unobserved Heterogeneity," The B.E. Journal of Economic Analysis & Policy, De Gruyter, vol. 17(1), pages 1-20, February.
    17. Xavier Gabaix & Jean‐Michel Lasry & Pierre‐Louis Lions & Benjamin Moll, 2016. "The Dynamics of Inequality," Econometrica, Econometric Society, vol. 84, pages 2071-2111, November.
    18. Kenneth M. Johnson & Daniel T. Lichter, 2016. "Diverging Demography: Hispanic and Non-Hispanic Contributions to U.S. Population Redistribution and Diversity," Population Research and Policy Review, Springer;Southern Demographic Association (SDA), vol. 35(5), pages 705-725, October.
    19. Su, Guifu & Tu, Jianhua & Das, Kinkar Ch., 2015. "Graphs with fixed number of pendent vertices and minimal Zeroth-order general Randić index," Applied Mathematics and Computation, Elsevier, vol. 270(C), pages 705-710.
    20. Zbigniew Drewniak & Rafal Drewniak & Robert Karaszewski, 2020. "The Assessment of the Features of Inter-organisational Relationships: Benefits, Duration, Repeatability and Maturity of the Relationship with the Company's Stakeholders," European Research Studies Journal, European Research Studies Journal, vol. 0(Special 1), pages 443-461.
    21. Shannon M Sullivan & Doug Coyle & George Wells, 2014. "What Guidance Are Researchers Given on How to Present Network Meta-Analyses to End-Users such as Policymakers and Clinicians? A Systematic Review," PLOS ONE, Public Library of Science, vol. 9(12), pages 1-18, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0202563. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.