Printed from https://ideas.repec.org/a/plo/pone00/0198166.html
Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries
Author
Abstract
Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP) regulation remains unknown. We hypothesized that a genome-wide association study accounting for gene-alcohol consumption interaction for BP might identify additional BP loci and contribute to the understanding of alcohol-related BP regulation. We conducted a large two-stage investigation incorporating joint testing of main genetic effects and single nucleotide variant (SNV)-alcohol consumption interactions. In Stage 1, genome-wide discovery meta-analyses in ≈131K individuals across several ancestry groups yielded 3,514 SNVs (245 loci) with suggestive evidence of association (P
Suggested Citation
DOI: 10.1371/journal.pone.0198166
Download full text from publisher
References listed on IDEAS
- Jason Ernst & Pouya Kheradpour & Tarjei S. Mikkelsen & Noam Shoresh & Lucas D. Ward & Charles B. Epstein & Xiaolan Zhang & Li Wang & Robbyn Issner & Michael Coyne & Manching Ku & Timothy Durham & Mano, 2011. "Mapping and analysis of chromatin state dynamics in nine human cell types," Nature, Nature, vol. 473(7345), pages 43-49, May.
- Alexander I. Young & Fabian Wauthier & Peter Donnelly, 2016. "Multiple novel gene-by-environment interactions modify the effect of FTO variants on body mass index," Nature Communications, Nature, vol. 7(1), pages 1-12, November.
- Rajagopal, 2014.
"The Human Factors,"
Palgrave Macmillan Books, in: Architecting Enterprise, chapter 9, pages 225-249,
Palgrave Macmillan.
- Rajagopal, 2013. "The Human Factors," Palgrave Macmillan Books, in: Managing Social Media and Consumerism, chapter 9, pages 173-194, Palgrave Macmillan.
- Jacob F. Degner & Athma A. Pai & Roger Pique-Regi & Jean-Baptiste Veyrieras & Daniel J. Gaffney & Joseph K. Pickrell & Sherryl De Leon & Katelyn Michelini & Noah Lewellen & Gregory E. Crawford & Matth, 2012. "DNase I sensitivity QTLs are a major determinant of human expression variation," Nature, Nature, vol. 482(7385), pages 390-394, February.
Citations
Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
Cited by:
- Surina Singh & Ananyo Choudhury & Scott Hazelhurst & Nigel J. Crowther & Palwendé R. Boua & Hermann Sorgho & Godfred Agongo & Engelbert A. Nonterah & Lisa K. Micklesfield & Shane A. Norris & Isaac Kis, 2023. "Genome-wide association study meta-analysis of blood pressure traits and hypertension in sub-Saharan African populations: an AWI-Gen study," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
Most related items
These are the items that most often cite the same works as this one and are cited by the same works as this one.- Rahman, Shaikh Moksadur, 2020. "Relationship between Job Satisfaction and Turnover Intention: Evidence from Bangladesh," Asian Business Review, Asian Business Consortium, vol. 10(2), pages 99-108.
- Wang Kai, 2019. "Towards a Taxonomy of Idea Generation Techniques," Foundations of Management, Sciendo, vol. 11(1), pages 65-80, January.
- Bridgelall, Raj & Stubbing, Edward, 2021. "Forecasting the effects of autonomous vehicles on land use," Technological Forecasting and Social Change, Elsevier, vol. 163(C).
- Bevilacqua, Maurizio & Ciarapica, Filippo Emanuele, 2018. "Human factor risk management in the process industry: A case study," Reliability Engineering and System Safety, Elsevier, vol. 169(C), pages 149-159.
- Naveena Prakasam & Louisa Huxtable-Thomas, 2021. "Reddit: Affordances as an Enabler for Shifting Loyalties," Information Systems Frontiers, Springer, vol. 23(3), pages 723-751, June.
- Colin Jerolmack & Alexandra K. Murphy, 2019. "The Ethical Dilemmas and Social Scientific Trade-offs of Masking in Ethnography," Sociological Methods & Research, , vol. 48(4), pages 801-827, November.
- Valeriy Makarov & Albert Bakhtizin, 2014. "The Estimation Of The Regions’ Efficiency Of The Russian Federation Including The Intellectual Capital, The Characteristics Of Readiness For Innovation, Level Of Well-Being, And Quality Of Life," Economy of region, Centre for Economic Security, Institute of Economics of Ural Branch of Russian Academy of Sciences, vol. 1(4), pages 9-30.
- Zhao, Jing & Knoop, Victor L. & Wang, Meng, 2020. "Two-dimensional vehicular movement modelling at intersections based on optimal control," Transportation Research Part B: Methodological, Elsevier, vol. 138(C), pages 1-22.
- Kristine Edgar Danielyan & Samvel Grigoriy Chailyan, 2019. "Delineation of Effectors Impact on The Human Brain Derived Phosphoribosylpyrophosphate Synthetase-1 Activity," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 24(1), pages 17918-17926, December.
- Chuan Wang & Yupeng Liu & Wen Hou & Chao Yu & Guorong Wang & Yuyan Zheng, 2021. "Reliability and availability modeling of Subsea Autonomous High Integrity Pressure Protection System with partial stroke test by Dynamic Bayesian," Journal of Risk and Reliability, , vol. 235(2), pages 268-281, April.
- Mohammad AL-Zoubi, 2018. "The Role of Technology, Organization, and Environment Factors in Enterprise Resource Planning Implementation Success in Jordan," International Business Research, Canadian Center of Science and Education, vol. 11(8), pages 48-65, August.
- Damgaard, Mette Trier & Nielsen, Helena Skyt, 2018.
"Nudging in education,"
Economics of Education Review, Elsevier, vol. 64(C), pages 313-342.
- Mette Trier Damgaard & Helena Skyt Nielsen, 2017. "Nudging in education," Economics Working Papers 2017-05, Department of Economics and Business Economics, Aarhus University.
- Damgaard, Mette Trier & Nielsen, Helena Skyt, 2018. "Nudging in Education," IZA Discussion Papers 11454, Institute of Labor Economics (IZA).
- Nicole D. Sintov & P. Wesley Schultz, 2017. "Adjustable Green Defaults Can Help Make Smart Homes More Sustainable," Sustainability, MDPI, vol. 9(4), pages 1-12, April.
- Hwang, ShinYoung & Kim Seongcheol, 2017. "What triggers the use of mIM service provider’s sequel O2O service extensions?," 14th ITS Asia-Pacific Regional Conference, Kyoto 2017: Mapping ICT into Transformation for the Next Information Society 168494, International Telecommunications Society (ITS).
- Sana Sadiq & Khadija Anasse & Najib Slimani, 2022. "The impact of mobile phones on high school students: connecting the research dots," Technium Social Sciences Journal, Technium Science, vol. 30(1), pages 252-270, April.
- Maude Hasbi & Antoine Dubus, 2019. "Determinants of Mobile Broadband Use in Developing Economies: Evidence from Sub-Saharan Africa," Working Papers hal-02264651, HAL.
- Jascha-Alexander Koch & Michael Siering, 2019. "The recipe of successful crowdfunding campaigns," Electronic Markets, Springer;IIM University of St. Gallen, vol. 29(4), pages 661-679, December.
- Martins, José & Costa, Catarina & Oliveira, Tiago & Gonçalves, Ramiro & Branco, Frederico, 2019. "How smartphone advertising influences consumers' purchase intention," Journal of Business Research, Elsevier, vol. 94(C), pages 378-387.
- Retina Rimal & Chris Papadopoulos, 2016. "The mental health of sexually trafficked female survivors in Nepal," International Journal of Social Psychiatry, , vol. 62(5), pages 487-495, August.
- Wu, Bing & Yip, Tsz Leung & Yan, Xinping & Guedes Soares, C., 2022. "Review of techniques and challenges of human and organizational factors analysis in maritime transportation," Reliability Engineering and System Safety, Elsevier, vol. 219(C).
Corrections
All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0198166. See general information about how to correct material in RePEc.
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .
Please note that corrections may take a couple of weeks to filter through the various RePEc services.