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Multiple novel gene-by-environment interactions modify the effect of FTO variants on body mass index

Author

Listed:
  • Alexander I. Young

    (Wellcome Trust Centre for Human Genetics, University of Oxford)

  • Fabian Wauthier

    (Wellcome Trust Centre for Human Genetics, University of Oxford
    University of Oxford)

  • Peter Donnelly

    (Wellcome Trust Centre for Human Genetics, University of Oxford
    University of Oxford)

Abstract

Genetic studies have shown that obesity risk is heritable and that, of the many common variants now associated with body mass index, those in an intron of the fat mass and obesity-associated (FTO) gene have the largest effect. The size of the UK Biobank, and its joint measurement of genetic, anthropometric and lifestyle variables, offers an unprecedented opportunity to assess gene-by-environment interactions in a way that accounts for the dependence between different factors. We jointly examine the evidence for interactions between FTO (rs1421085) and various lifestyle and environmental factors. We report interactions between the FTO variant and each of: frequency of alcohol consumption (P=3.0 × 10−4); deviations from mean sleep duration (P=8.0 × 10−4); overall diet (P=5.0 × 10−6), including added salt (P=1.2 × 10−3); and physical activity (P=3.1 × 10−4).

Suggested Citation

  • Alexander I. Young & Fabian Wauthier & Peter Donnelly, 2016. "Multiple novel gene-by-environment interactions modify the effect of FTO variants on body mass index," Nature Communications, Nature, vol. 7(1), pages 1-12, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12724
    DOI: 10.1038/ncomms12724
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    Cited by:

    1. Sujin Kim & Juhwan Oh & Jongho Heo & Hwa-Young Lee & Jong-Koo Lee & S V Subramanian & Daehee Kang, 2018. "Socioeconomic inequalities in the prevalence of biomarkers of cardio-metabolic disease in South Korea: Comparison of the Health Examinees Study to a nationally representative survey," PLOS ONE, Public Library of Science, vol. 13(4), pages 1-13, April.
    2. Augustine Denteh & Daniel L. Millimet & Rusty Tchernis, 2019. "The origins of early childhood anthropometric persistence," Empirical Economics, Springer, vol. 56(6), pages 2185-2224, June.
    3. Mathias Rask-Andersen & Torgny Karlsson & Weronica E Ek & Åsa Johansson, 2017. "Gene-environment interaction study for BMI reveals interactions between genetic factors and physical activity, alcohol consumption and socioeconomic status," PLOS Genetics, Public Library of Science, vol. 13(9), pages 1-20, September.
    4. Mary F Feitosa & Aldi T Kraja & Daniel I Chasman & Yun J Sung & Thomas W Winkler & Ioanna Ntalla & Xiuqing Guo & Nora Franceschini & Ching-Yu Cheng & Xueling Sim & Dina Vojinovic & Jonathan Marten & S, 2018. "Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries," PLOS ONE, Public Library of Science, vol. 13(6), pages 1-36, June.

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