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Is periodontitis a risk indicator for cancer? A meta-analysis

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  • Stefano Corbella
  • Paolo Veronesi
  • Viviana Galimberti
  • Roberto Weinstein
  • Massimo Del Fabbro
  • Luca Francetti

Abstract

Background: The aim of the present systematic review was to evaluate the hypothesis of an association between periodontitis and the development of cancer. Methods: Two reviewers independently screened electronic and manual sources for pertinent articles. Primary outcome measures were the occurrence of neoplasm diagnosis in exposed and non-exposed groups, reported to evaluate association between cancer and periodontitis. Results: Of the 490 initially retrieved papers 10 were included in the qualitative synthesis and eight in the quantitative synthesis; the eight papers covered six studies. Considering hazard ratios, a statistically significant association was found for all cancers studied (1.14; CI 95%: 1.04, 1.24), digestive tract cancer (1.34; CI 95%: 1.05, 1.72), pancreatic cancer (1.74; CI 95%: 1.21, 2.52), prostate cancer (1.25; CI 95%: 1.04, 1.51), breast cancer (1.11; CI 95%: 1.00, 1.23), corpus uteri cancer (2.20; CI 95%: 1.16, 4.18), lung cancer (1.24; CI 95%: 1.06, 1.45), hematological cancer (1.30; CI 95%: 1.11, 1.53), esophagus / oropharyngeal cancer pooled together (2.25; CI 95%: 1.30, 3.90) and Non-Hodgkin lymphoma (1.30; CI 95%: 1.11, 1.52). Conclusions: Despite the sparse scientific evidence and considering the low statistical power of the results, this systematic review revealed a substantial lack of studies with standardized and comparable methods to speculate about the association between periodontitis and cancer; more studies are need in order to explore further the scientific evidence of such correlation.

Suggested Citation

  • Stefano Corbella & Paolo Veronesi & Viviana Galimberti & Roberto Weinstein & Massimo Del Fabbro & Luca Francetti, 2018. "Is periodontitis a risk indicator for cancer? A meta-analysis," PLOS ONE, Public Library of Science, vol. 13(4), pages 1-15, April.
    • Handle: RePEc:plo:pone00:0195683
    DOI: 10.1371/journal.pone.0195683
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    References listed on IDEAS

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    1. Jeffrey C. Valentine & Therese D. Pigott & Hannah R. Rothstein, 2010. "How Many Studies Do You Need?," Journal of Educational and Behavioral Statistics, , vol. 35(2), pages 215-247, April.
    2. Xian-Tao Zeng & Ai-Ping Deng & Cheng Li & Ling-Yun Xia & Yu-Ming Niu & Wei-Dong Leng, 2013. "Periodontal Disease and Risk of Head and Neck Cancer: A Meta-Analysis of Observational Studies," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-1, October.
    3. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
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    1. Ping-Ju Chen & Yin-Yang Chen & Chiao-Wen Lin & Ying-Tung Yeh & Han-Wei Yeh & Jing-Yang Huang & Shun-Fa Yang & Chao-Bin Yeh, 2020. "Effect of Periodontitis and Scaling and Root Planing on Risk of Pharyngeal Cancer: A Nested Case—Control Study," IJERPH, MDPI, vol. 18(1), pages 1-12, December.

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