IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2020i1p8-d466362.html
   My bibliography  Save this article

Effect of Periodontitis and Scaling and Root Planing on Risk of Pharyngeal Cancer: A Nested Case—Control Study

Author

Listed:
  • Ping-Ju Chen

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Dentistry, Changhua Christian Hospital, Changhua 500, Taiwan
    These authors contributed equally to the work.)

  • Yin-Yang Chen

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Surgery, Chung Shan Medical University Hospital, Taichung 402, Taiwan
    These authors contributed equally to the work.)

  • Chiao-Wen Lin

    (Institute of Oral Sciences, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Dentistry, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

  • Ying-Tung Yeh

    (Department of Dentistry, Chung Shan Medical University Hospital, Taichung 402, Taiwan
    Graduate School of Dentistry, School of Dentistry, Chung Shan Medical University, Taichung 402, Taiwan)

  • Han-Wei Yeh

    (School of Medicine, Chang Gung University, Taoyuan City 333, Taiwan)

  • Jing-Yang Huang

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

  • Shun-Fa Yang

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

  • Chao-Bin Yeh

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Emergency Medicine, School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Emergency Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

Abstract

This study investigated the association between periodontitis and the risk of pharyngeal cancer in Taiwan. For this population-based nested case–control study using the Longitudinal Health Insurance Database derived from Taiwan’s National Health Insurance Research Database, we identified patients ( n = 1292) who were newly diagnosed with pharyngeal cancer between 2005 and 2013 and exactly paired them with propensity score matched control subjects ( n = 2584). Periodontitis and scaling and root planing (SRP) were identified before the index date. Pharyngeal cancer was subdivided into 3 subgroups on the basis of anatomic location: nasopharyngeal cancer, oropharyngeal cancer, and hypopharyngeal cancer. A multiple conditional logistic regression model was applied to analyze the adjusted odds ratio (aOR). Periodontitis was associated with an increased risk of pharyngeal cancer (aOR, 1.57; 95% confidence interval (CI), 1.17 to 2.10), especially oropharyngeal cancer (aOR, 2.22; 95% CI, 1.07 to 4.60). We found a decreased risk of pharyngeal cancer in patients who had undergone SRP (aOR, 0.77; 95% CI, 0.61 to 0.96). In conclusion, this study showed that periodontitis was associated with an increased risk of pharyngeal cancer and SRP exerted a protective effect against pharyngeal cancer. Our results suggest that treating periodontitis and performing SRP, which are modifiable factors in oral health, in clinical practice may provide an opportunity to decrease the disease burden of pharyngeal cancer in Taiwan.

Suggested Citation

  • Ping-Ju Chen & Yin-Yang Chen & Chiao-Wen Lin & Ying-Tung Yeh & Han-Wei Yeh & Jing-Yang Huang & Shun-Fa Yang & Chao-Bin Yeh, 2020. "Effect of Periodontitis and Scaling and Root Planing on Risk of Pharyngeal Cancer: A Nested Case—Control Study," IJERPH, MDPI, vol. 18(1), pages 1-12, December.
    • Handle: RePEc:gam:jijerp:v:18:y:2020:i:1:p:8-:d:466362
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/1/8/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/18/1/8/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Stefano Corbella & Paolo Veronesi & Viviana Galimberti & Roberto Weinstein & Massimo Del Fabbro & Luca Francetti, 2018. "Is periodontitis a risk indicator for cancer? A meta-analysis," PLOS ONE, Public Library of Science, vol. 13(4), pages 1-15, April.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.

      Corrections

      All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2020:i:1:p:8-:d:466362. See general information about how to correct material in RePEc.

      If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

      If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

      If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

      For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

      Please note that corrections may take a couple of weeks to filter through the various RePEc services.

      IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.