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A Conceptual Framework for Mapping Quantitative Trait Loci Regulating Ontogenetic Allometry

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  • Hongying Li
  • Zhongwen Huang
  • Junyi Gai
  • Song Wu
  • Yanru Zeng
  • Qin Li
  • Rongling Wu

Abstract

Although ontogenetic changes in body shape and its associated allometry has been studied for over a century, essentially nothing is known about their underlying genetic and developmental mechanisms. One of the reasons for this ignorance is the unavailability of a conceptual framework to formulate the experimental design for data collection and statistical models for data analyses. We developed a framework model for unraveling the genetic machinery for ontogenetic changes of allometry. The model incorporates the mathematical aspects of ontogenetic growth and allometry into a maximum likelihood framework for quantitative trait locus (QTL) mapping. As a quantitative platform, the model allows for the testing of a number of biologically meaningful hypotheses to explore the pleiotropic basis of the QTL that regulate ontogeny and allometry. Simulation studies and real data analysis of a live example in soybean have been performed to investigate the statistical behavior of the model and validate its practical utilization. The statistical model proposed will help to study the genetic architecture of complex phenotypes and, therefore, gain better insights into the mechanistic regulation for developmental patterns and processes in organisms.

Suggested Citation

  • Hongying Li & Zhongwen Huang & Junyi Gai & Song Wu & Yanru Zeng & Qin Li & Rongling Wu, 2007. "A Conceptual Framework for Mapping Quantitative Trait Loci Regulating Ontogenetic Allometry," PLOS ONE, Public Library of Science, vol. 2(11), pages 1-10, November.
    • Handle: RePEc:plo:pone00:0001245
    DOI: 10.1371/journal.pone.0001245
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    References listed on IDEAS

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    1. Geoffrey B. West & James H. Brown & Brian J. Enquist, 1999. "A general model for the structure and allometry of plant vascular systems," Nature, Nature, vol. 400(6745), pages 664-667, August.
    2. Brian J. Enquist & Karl J. Niklas, 2001. "Invariant scaling relations across tree-dominated communities," Nature, Nature, vol. 410(6829), pages 655-660, April.
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    Cited by:

    1. Anthony Papadopoulos, 2011. "Stochastic Ontogenetic Allometry: The Statistical Dynamics of Relative Growth," PLOS ONE, Public Library of Science, vol. 6(9), pages 1-8, September.
    2. Mi Xiaojuan & Eskridge Kent & Wang Dong & Baenziger P. Stephen & Campbell B. Todd & Gill Kulvinder S. & Dweikat Ismail & Bovaird James, 2010. "Regression-Based Multi-Trait QTL Mapping Using a Structural Equation Model," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 9(1), pages 1-23, October.

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