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A roadmap to precision medicine through post-genomic electronic medical records

Author

Listed:
  • Kevin M. Mendez

    (Brigham and Women’s Hospital and Harvard Medical School
    Edith Cowan University)

  • Stacey N. Reinke

    (Edith Cowan University)

  • Rachel S. Kelly

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Qingwen Chen

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Mark Su

    (Personal Care Physicians of Greater Newburyport)

  • Michael McGeachie

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Scott Weiss

    (Brigham and Women’s Hospital and Harvard Medical School)

  • David I. Broadhurst

    (Edith Cowan University)

  • Jessica A. Lasky-Su

    (Brigham and Women’s Hospital and Harvard Medical School)

Abstract

The promise of integrating Electronic Medical Records (EMR) and genetic data for precision medicine has largely fallen short due to its omission of environmental context over time. Post-genomic data can bridge this gap by capturing the real-time dynamic relationship between underlying genetics and the environment. This perspective highlights the pivotal role of integrating EMR and post-genomics for personalized health, reflecting on lessons from past efforts, and outlining a roadmap of challenges and opportunities that must be addressed to realize the potential of precision medicine.

Suggested Citation

  • Kevin M. Mendez & Stacey N. Reinke & Rachel S. Kelly & Qingwen Chen & Mark Su & Michael McGeachie & Scott Weiss & David I. Broadhurst & Jessica A. Lasky-Su, 2025. "A roadmap to precision medicine through post-genomic electronic medical records," Nature Communications, Nature, vol. 16(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-56442-4
    DOI: 10.1038/s41467-025-56442-4
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    References listed on IDEAS

    as
    1. Finkler, Kaja & Skrzynia, Cécile & Evans, James P., 2003. "The new genetics and its consequences for family, kinship, medicine and medical genetics," Social Science & Medicine, Elsevier, vol. 57(3), pages 403-412, August.
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    5. Peter J. Turnbaugh & Ruth E. Ley & Micah Hamady & Claire M. Fraser-Liggett & Rob Knight & Jeffrey I. Gordon, 2007. "The Human Microbiome Project," Nature, Nature, vol. 449(7164), pages 804-810, October.
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