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Genomics is failing on diversity

Author

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  • Alice B. Popejoy

    (Alice B. Popejoy is a PhD candidate at the Institute for Public Health Genetics (IPHG) at the University of Washington, Seattle, USA.)

  • Stephanie M. Fullerton

    (Stephanie M. Fullerton is associate professor of bioethics and humanities at the University of Washington, Seattle, USA.)

Abstract

An analysis by Alice B. Popejoy and Stephanie M. Fullerton indicates that some populations are still being left behind on the road to precision medicine.

Suggested Citation

  • Alice B. Popejoy & Stephanie M. Fullerton, 2016. "Genomics is failing on diversity," Nature, Nature, vol. 538(7624), pages 161-164, October.
    • Handle: RePEc:nat:nature:v:538:y:2016:i:7624:d:10.1038_538161a
    DOI: 10.1038/538161a
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    Citations

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    Cited by:

    1. Lauren S Mogil & Angela Andaleon & Alexa Badalamenti & Scott P Dickinson & Xiuqing Guo & Jerome I Rotter & W Craig Johnson & Hae Kyung Im & Yongmei Liu & Heather E Wheeler, 2018. "Genetic architecture of gene expression traits across diverse populations," PLOS Genetics, Public Library of Science, vol. 14(8), pages 1-21, August.
    2. Ido Amit & Kristin Ardlie & Fabiana Arzuaga & Gordon Awandare & Gary Bader & Alexander Bernier & Piero Carninci & Stacey Donnelly & Roland Eils & Alistair R. R. Forrest & Henry T. Greely & Roderic Gui, 2024. "The commitment of the human cell atlas to humanity," Nature Communications, Nature, vol. 15(1), pages 1-7, December.
    3. Kevin M. Mendez & Stacey N. Reinke & Rachel S. Kelly & Qingwen Chen & Mark Su & Michael McGeachie & Scott Weiss & David I. Broadhurst & Jessica A. Lasky-Su, 2025. "A roadmap to precision medicine through post-genomic electronic medical records," Nature Communications, Nature, vol. 16(1), pages 1-12, December.
    4. Kevin L Keys & Angel C Y Mak & Marquitta J White & Walter L Eckalbar & Andrew W Dahl & Joel Mefford & Anna V Mikhaylova & María G Contreras & Jennifer R Elhawary & Celeste Eng & Donglei Hu & Scott Hun, 2020. "On the cross-population generalizability of gene expression prediction models," PLOS Genetics, Public Library of Science, vol. 16(8), pages 1-28, August.
    5. Jingning Zhang & Jianan Zhan & Jin Jin & Cheng Ma & Ruzhang Zhao & Jared O’Connell & Yunxuan Jiang & Bertram L. Koelsch & Haoyu Zhang & Nilanjan Chatterjee, 2024. "An ensemble penalized regression method for multi-ancestry polygenic risk prediction," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    6. Wei Fu & Shin-Yi Chou & Li-San Wang, 2022. "NIH Grant Expansion, Ancestral Diversity and Scientific Discovery in Genomics Research," NBER Working Papers 30155, National Bureau of Economic Research, Inc.
    7. Brandy M Mapes & Christopher S Foster & Sheila V Kusnoor & Marcia I Epelbaum & Mona AuYoung & Gwynne Jenkins & Maria Lopez-Class & Dara Richardson-Heron & Ahmed Elmi & Karl Surkan & Robert M Cronin & , 2020. "Diversity and inclusion for the All of Us research program: A scoping review," PLOS ONE, Public Library of Science, vol. 15(7), pages 1-14, July.
    8. Nadine R. Caron & Wilf Adam & Kate Anderson & Brooke T. Boswell & Meck Chongo & Viktor Deineko & Alexanne Dick & Shannon E. Hall & Jessica T. Hatcher & Patricia Howard & Megan Hunt & Kevin Linn & Ashl, 2023. "Partnering with First Nations in Northern British Columbia Canada to Reduce Inequity in Access to Genomic Research," IJERPH, MDPI, vol. 20(10), pages 1-31, May.
    9. Ananyo Choudhury & Jean-Tristan Brandenburg & Tinashe Chikowore & Dhriti Sengupta & Palwende Romuald Boua & Nigel J. Crowther & Godfred Agongo & Gershim Asiki & F. Xavier Gómez-Olivé & Isaac Kisiangan, 2022. "Meta-analysis of sub-Saharan African studies provides insights into genetic architecture of lipid traits," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    10. Shim, Janet K. & Bentz, Michael & Vasquez, Emily & Jeske, Melanie & Saperstein, Aliya & Fullerton, Stephanie M. & Foti, Nicole & McMahon, Caitlin & Lee, Sandra Soo-Jin, 2022. "Strategies of inclusion: The tradeoffs of pursuing “baked in” diversity through place-based recruitment," Social Science & Medicine, Elsevier, vol. 306(C).
    11. Rohini Chakravarthy & Sarah C Stallings & Michael Williams & Megan Hollister & Mario Davidson & Juan Canedo & Consuelo H Wilkins, 2020. "Factors influencing precision medicine knowledge and attitudes," PLOS ONE, Public Library of Science, vol. 15(11), pages 1-14, November.
    12. Brieuc Lehmann & Maxine Mackintosh & Gil McVean & Chris Holmes, 2023. "Optimal strategies for learning multi-ancestry polygenic scores vary across traits," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    13. Baier, Tina & Lyngstad, Torkild Hovde, 2024. "Social Background Effects on Educational Outcomes - New Insights from Modern Genetic Science," EconStor Open Access Articles and Book Chapters, ZBW - Leibniz Information Centre for Economics, vol. 76(3), pages 525-545.
    14. Naser Ansari-Pour & Yonglan Zheng & Toshio F. Yoshimatsu & Ayodele Sanni & Mustapha Ajani & Jean-Baptiste Reynier & Avraam Tapinos & Jason J. Pitt & Stefan Dentro & Anna Woodard & Padma Sheila Rajagop, 2021. "Whole-genome analysis of Nigerian patients with breast cancer reveals ethnic-driven somatic evolution and distinct genomic subtypes," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    15. Jiacheng Miao & Hanmin Guo & Gefei Song & Zijie Zhao & Lin Hou & Qiongshi Lu, 2023. "Quantifying portable genetic effects and improving cross-ancestry genetic prediction with GWAS summary statistics," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    16. Ghislain Rocheleau & Shoa L. Clarke & Gaëlle Auguste & Natalie R. Hasbani & Alanna C. Morrison & Adam S. Heath & Lawrence F. Bielak & Kruthika R. Iyer & Erica P. Young & Nathan O. Stitziel & Goo Jun &, 2024. "Rare variant contribution to the heritability of coronary artery disease," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    17. Michel S. Naslavsky & Marilia O. Scliar & Guilherme L. Yamamoto & Jaqueline Yu Ting Wang & Stepanka Zverinova & Tatiana Karp & Kelly Nunes & José Ricardo Magliocco Ceroni & Diego Lima Carvalho & Carlo, 2022. "Whole-genome sequencing of 1,171 elderly admixed individuals from Brazil," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    18. Surina Singh & Ananyo Choudhury & Scott Hazelhurst & Nigel J. Crowther & Palwendé R. Boua & Hermann Sorgho & Godfred Agongo & Engelbert A. Nonterah & Lisa K. Micklesfield & Shane A. Norris & Isaac Kis, 2023. "Genome-wide association study meta-analysis of blood pressure traits and hypertension in sub-Saharan African populations: an AWI-Gen study," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    19. Brenton R Swenson & Tin Louie & Henry J Lin & Raúl Méndez-Giráldez & Jennifer E Below & Cathy C Laurie & Kathleen F Kerr & Heather Highland & Timothy A Thornton & Kelli K Ryckman & Charles Kooperberg , 2019. "GWAS of QRS duration identifies new loci specific to Hispanic/Latino populations," PLOS ONE, Public Library of Science, vol. 14(6), pages 1-15, June.
    20. Irene Unceta & Jordi Nin & Oriol Pujol, 2020. "Risk mitigation in algorithmic accountability: The role of machine learning copies," PLOS ONE, Public Library of Science, vol. 15(11), pages 1-26, November.
    21. Alesha A. Hatton & Fei-Fei Cheng & Tian Lin & Ren-Juan Shen & Jie Chen & Zhili Zheng & Jia Qu & Fan Lyu & Sarah E. Harris & Simon R. Cox & Zi-Bing Jin & Nicholas G. Martin & Dongsheng Fan & Grant W. M, 2024. "Genetic control of DNA methylation is largely shared across European and East Asian populations," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    22. Pei-Kuan Cong & Wei-Yang Bai & Jin-Chen Li & Meng-Yuan Yang & Saber Khederzadeh & Si-Rui Gai & Nan Li & Yu-Heng Liu & Shi-Hui Yu & Wei-Wei Zhao & Jun-Quan Liu & Yi Sun & Xiao-Wei Zhu & Pian-Pian Zhao , 2022. "Genomic analyses of 10,376 individuals in the Westlake BioBank for Chinese (WBBC) pilot project," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    23. Sara H Katsanis & Elaine Huang & Amanda Young & Victoria Grant & Elizabeth Warner & Sharon Larson & Jennifer K Wagner, 2019. "Caring for trafficked and unidentified patients in the EHR shadows: Shining a light by sharing the data," PLOS ONE, Public Library of Science, vol. 14(3), pages 1-22, March.
    24. Jie Ping & Guochong Jia & Qiuyin Cai & Xingyi Guo & Ran Tao & Christine Ambrosone & Dezheng Huo & Stefan Ambs & Mollie E. Barnard & Yu Chen & Montserrat Garcia-Closas & Jian Gu & Jennifer J. Hu & Esth, 2024. "Using genome and transcriptome data from African-ancestry female participants to identify putative breast cancer susceptibility genes," Nature Communications, Nature, vol. 15(1), pages 1-8, December.
    25. Evans, Linnea & Engelman, Michal & Mikulas, Alex & Malecki, Kristen, 2021. "How are social determinants of health integrated into epigenetic research? A systematic review," Social Science & Medicine, Elsevier, vol. 273(C).

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