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A dynamic subset of network interactions underlies tuning to natural movements in marmoset sensorimotor cortex

Author

Listed:
  • Dalton D. Moore

    (University of Chicago)

  • Jason N. MacLean

    (University of Chicago
    University of Chicago
    University of Chicago Neuroscience Institute)

  • Jeffrey D. Walker

    (University of Chicago)

  • Nicholas G. Hatsopoulos

    (University of Chicago
    University of Chicago
    University of Chicago Neuroscience Institute)

Abstract

Mechanisms of computation in sensorimotor cortex must be flexible and robust to support skilled motor behavior. Patterns of neuronal coactivity emerge as a result of computational processes. Pairwise spike-time statistical relationships, across the population, can be summarized as a functional network (FN) which retains single-unit properties. We record populations of single-unit neural activity in marmoset forelimb sensorimotor cortex during prey capture and spontaneous behavior and use an encoding model incorporating kinematic trajectories and network features to predict single-unit activity during forelimb movements. The contribution of network features depends on structured connectivity within strongly connected functional groups. We identify a context-specific functional group that is highly tuned to kinematics and reorganizes its connectivity between spontaneous and prey capture movements. In the remaining context-invariant group, interactions are comparatively stable across behaviors and units are less tuned to kinematics. This suggests different roles in producing natural forelimb movements and contextualizes single-unit tuning properties within population dynamics.

Suggested Citation

  • Dalton D. Moore & Jason N. MacLean & Jeffrey D. Walker & Nicholas G. Hatsopoulos, 2024. "A dynamic subset of network interactions underlies tuning to natural movements in marmoset sensorimotor cortex," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-54343-6
    DOI: 10.1038/s41467-024-54343-6
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    References listed on IDEAS

    as
    1. A. H. Lara & J. P. Cunningham & M. M. Churchland, 2018. "Different population dynamics in the supplementary motor area and motor cortex during reaching," Nature Communications, Nature, vol. 9(1), pages 1-16, December.
    2. Mark M. Churchland & John P. Cunningham & Matthew T. Kaufman & Justin D. Foster & Paul Nuyujukian & Stephen I. Ryu & Krishna V. Shenoy, 2012. "Neural population dynamics during reaching," Nature, Nature, vol. 487(7405), pages 51-56, July.
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