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Deciphering bat influenza H18N11 infection dynamics in male Jamaican fruit bats on a single-cell level

Author

Listed:
  • Susanne Kessler

    (Medical Center University of Freiburg
    University of Freiburg)

  • Bradly Burke

    (Colorado State University)

  • Geoffroy Andrieux

    (University of Freiburg
    Medical Center - University of Freiburg)

  • Jan Schinköthe

    (Leipzig University)

  • Lea Hamberger

    (Medical Center University of Freiburg
    University of Freiburg)

  • Johannes Kacza

    (University of Leipzig)

  • Shijun Zhan

    (Colorado State University)

  • Clara Reasoner

    (Colorado State University)

  • Taru S. Dutt

    (Colorado State University)

  • Maria Kaukab Osman

    (Medical Center University of Freiburg
    University of Freiburg
    University of Freiburg
    University of Freiburg)

  • Marcela Henao-Tamayo

    (Colorado State University)

  • Julian Staniek

    (University of Freiburg
    University of Freiburg
    Medical Center - University of Freiburg)

  • Jose Francisco Villena Ossa

    (Medical Center - University of Freiburg
    Medical Center-University of Freiburg)

  • Dalit T. Frank

    (Colorado State University)

  • Wenjun Ma

    (University of Missouri)

  • Reiner Ulrich

    (Leipzig University)

  • Toni Cathomen

    (University of Freiburg
    Medical Center - University of Freiburg
    Medical Center-University of Freiburg)

  • Melanie Boerries

    (University of Freiburg
    Medical Center - University of Freiburg
    Partner site Freiburg, a partnership between DKFZ and Medical Center - University of Freiburg)

  • Marta Rizzi

    (University of Freiburg
    Medical Center - University of Freiburg
    University of Freiburg
    Medical University of Vienna)

  • Martin Beer

    (Friedrich-Loeffler-Institut)

  • Martin Schwemmle

    (Medical Center University of Freiburg
    University of Freiburg)

  • Peter Reuther

    (Medical Center University of Freiburg
    University of Freiburg)

  • Tony Schountz

    (Colorado State University)

  • Kevin Ciminski

    (Medical Center University of Freiburg
    University of Freiburg)

Abstract

Jamaican fruit bats (Artibeus jamaicensis) naturally harbor a wide range of viruses of human relevance. These infections are typically mild in bats, suggesting unique features of their immune system. To better understand the immune response to viral infections in bats, we infected male Jamaican fruit bats with the bat-derived influenza A virus (IAV) H18N11. Using comparative single-cell RNA sequencing, we generated single-cell atlases of the Jamaican fruit bat intestine and mesentery. Gene expression profiling showed that H18N11 infection resulted in a moderate induction of interferon-stimulated genes and transcriptional activation of immune cells. H18N11 infection was predominant in various leukocytes, including macrophages, B cells, and NK/T cells. Confirming these findings, human leukocytes, particularly macrophages, were also susceptible to H18N11, highlighting the zoonotic potential of this bat-derived IAV. Our study provides insight into a natural virus-host relationship and thus serves as a fundamental resource for future in-depth characterization of bat immunology.

Suggested Citation

  • Susanne Kessler & Bradly Burke & Geoffroy Andrieux & Jan Schinköthe & Lea Hamberger & Johannes Kacza & Shijun Zhan & Clara Reasoner & Taru S. Dutt & Maria Kaukab Osman & Marcela Henao-Tamayo & Julian , 2024. "Deciphering bat influenza H18N11 infection dynamics in male Jamaican fruit bats on a single-cell level," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-48934-6
    DOI: 10.1038/s41467-024-48934-6
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