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Modelling filovirus maintenance in nature by experimental transmission of Marburg virus between Egyptian rousette bats

Author

Listed:
  • Amy J. Schuh

    (Viral Special Pathogens Branch, Centers for Disease Control and Prevention)

  • Brian R. Amman

    (Viral Special Pathogens Branch, Centers for Disease Control and Prevention)

  • Megan E. B. Jones

    (Viral Special Pathogens Branch, Centers for Disease Control and Prevention
    College of Veterinary Medicine, University of Georgia
    Present address: Wildlife Diseases Laboratory, Institute for Conservation Research, San Diego Zoo Global, Escondido, California 92027, USA)

  • Tara K. Sealy

    (Viral Special Pathogens Branch, Centers for Disease Control and Prevention)

  • Luke S. Uebelhoer

    (Viral Special Pathogens Branch, Centers for Disease Control and Prevention
    Present address: Childhood Development and Rehabilitation Center, Oregon Health and Science University, Portland, Oregon 97239, USA)

  • Jessica R. Spengler

    (Viral Special Pathogens Branch, Centers for Disease Control and Prevention)

  • Brock E. Martin

    (Viral Special Pathogens Branch, Centers for Disease Control and Prevention
    Present address: Poxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA)

  • Jo Ann D. Coleman-McCray

    (Viral Special Pathogens Branch, Centers for Disease Control and Prevention)

  • Stuart T. Nichol

    (Viral Special Pathogens Branch, Centers for Disease Control and Prevention)

  • Jonathan S. Towner

    (Viral Special Pathogens Branch, Centers for Disease Control and Prevention
    College of Veterinary Medicine, University of Georgia)

Abstract

The Egyptian rousette bat (ERB) is a natural reservoir host for Marburg virus (MARV); however, the mechanisms by which MARV is transmitted bat-to-bat and to other animals are unclear. Here we co-house MARV-inoculated donor ERBs with naive contact ERBs. MARV shedding is detected in oral, rectal and urine specimens from inoculated bats from 5–19 days post infection. Simultaneously, MARV is detected in oral specimens from contact bats, indicating oral exposure to the virus. In the late study phase, we provide evidence that MARV can be horizontally transmitted from inoculated to contact ERBs by finding MARV RNA in blood and oral specimens from contact bats, followed by MARV IgG antibodies in these same bats. This study demonstrates that MARV can be horizontally transmitted from inoculated to contact ERBs, thereby providing a model for filovirus maintenance in its natural reservoir host and a potential mechanism for virus spillover to other animals.

Suggested Citation

  • Amy J. Schuh & Brian R. Amman & Megan E. B. Jones & Tara K. Sealy & Luke S. Uebelhoer & Jessica R. Spengler & Brock E. Martin & Jo Ann D. Coleman-McCray & Stuart T. Nichol & Jonathan S. Towner, 2017. "Modelling filovirus maintenance in nature by experimental transmission of Marburg virus between Egyptian rousette bats," Nature Communications, Nature, vol. 8(1), pages 1-10, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14446
    DOI: 10.1038/ncomms14446
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    Cited by:

    1. Susanne Kessler & Bradly Burke & Geoffroy Andrieux & Jan Schinköthe & Lea Hamberger & Johannes Kacza & Shijun Zhan & Clara Reasoner & Taru S. Dutt & Maria Kaukab Osman & Marcela Henao-Tamayo & Julian , 2024. "Deciphering bat influenza H18N11 infection dynamics in male Jamaican fruit bats on a single-cell level," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Sarah van Tol & Julia R. Port & Robert J. Fischer & Shane Gallogly & Trenton Bushmaker & Amanda Griffin & Jonathan E. Schulz & Aaron Carmody & Lara Myers & Daniel E. Crowley & Caylee A. Falvo & Jade C, 2025. "Jamaican fruit bats’ competence for Ebola but not Marburg virus is driven by intrinsic differences," Nature Communications, Nature, vol. 16(1), pages 1-18, December.
    3. S. A. Riesle-Sbarbaro & G. Wibbelt & A. Düx & V. Kouakou & M. Bokelmann & K. Hansen-Kant & N. Kirchoff & M. Laue & N. Kromarek & A. Lander & U. Vogel & A. Wahlbrink & D. M. Wozniak & D. P. Scott & J. , 2024. "Selective replication and vertical transmission of Ebola virus in experimentally infected Angolan free-tailed bats," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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