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Multi-area recordings and optogenetics in the awake, behaving marmoset

Author

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  • Patrick Jendritza

    (Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society
    International Max Planck Research School for Neural Circuits)

  • Frederike J. Klein

    (Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society)

  • Pascal Fries

    (Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society
    International Max Planck Research School for Neural Circuits
    Radboud University Nijmegen)

Abstract

The common marmoset has emerged as a key model in neuroscience. Marmosets are small in size, show great potential for genetic modification and exhibit complex behaviors. Thus, it is necessary to develop technology that enables monitoring and manipulation of the underlying neural circuits. Here, we describe a novel approach to record and optogenetically manipulate neural activity in awake, behaving marmosets. Our design utilizes a light-weight, 3D printed titanium chamber that can house several high-density silicon probes for semi-chronic recordings, while enabling simultaneous optogenetic stimulation. We demonstrate the application of our method in male marmosets by recording multi- and single-unit data from areas V1 and V6 with 192 channels simultaneously, and show that optogenetic activation of excitatory neurons in area V6 can influence behavior in a detection task. This method may enable future studies to investigate the neural basis of perception and behavior in the marmoset.

Suggested Citation

  • Patrick Jendritza & Frederike J. Klein & Pascal Fries, 2023. "Multi-area recordings and optogenetics in the awake, behaving marmoset," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36217-5
    DOI: 10.1038/s41467-023-36217-5
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    1. Erika Sasaki & Hiroshi Suemizu & Akiko Shimada & Kisaburo Hanazawa & Ryo Oiwa & Michiko Kamioka & Ikuo Tomioka & Yusuke Sotomaru & Reiko Hirakawa & Tomoo Eto & Seiji Shiozawa & Takuji Maeda & Mamoru I, 2009. "Generation of transgenic non-human primates with germline transmission," Nature, Nature, vol. 459(7246), pages 523-527, May.
    2. Zachary W. Davis & Lyle Muller & Julio Martinez-Trujillo & Terrence Sejnowski & John H. Reynolds, 2020. "Spontaneous travelling cortical waves gate perception in behaving primates," Nature, Nature, vol. 587(7834), pages 432-436, November.
    3. Berens, Philipp, 2009. "CircStat: A MATLAB Toolbox for Circular Statistics," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 31(i10).
    4. James J. Jun & Nicholas A. Steinmetz & Joshua H. Siegle & Daniel J. Denman & Marius Bauza & Brian Barbarits & Albert K. Lee & Costas A. Anastassiou & Alexandru Andrei & Çağatay Aydın & Mladen Barbic &, 2017. "Fully integrated silicon probes for high-density recording of neural activity," Nature, Nature, vol. 551(7679), pages 232-236, November.
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