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Simultaneous functional MRI of two awake marmosets

Author

Listed:
  • Kyle M. Gilbert

    (The University of Western Ontario
    The University of Western Ontario)

  • Justine C. Cléry

    (The University of Western Ontario)

  • Joseph S. Gati

    (The University of Western Ontario
    The University of Western Ontario)

  • Yuki Hori

    (The University of Western Ontario)

  • Kevin D. Johnston

    (The University of Western Ontario
    The University of Western Ontario)

  • Alexander Mashkovtsev

    (The University of Western Ontario)

  • Janahan Selvanayagam

    (The University of Western Ontario
    The University of Western Ontario)

  • Peter Zeman

    (The University of Western Ontario)

  • Ravi S. Menon

    (The University of Western Ontario
    The University of Western Ontario)

  • David J. Schaeffer

    (University of Pittsburgh)

  • Stefan Everling

    (The University of Western Ontario
    The University of Western Ontario)

Abstract

Social cognition is a dynamic process that requires the perception and integration of a complex set of idiosyncratic features between interacting conspecifics. Here we present a method for simultaneously measuring the whole-brain activation of two socially interacting marmoset monkeys using functional magnetic resonance imaging. MRI hardware (a radiofrequency coil and peripheral devices) and image-processing pipelines were developed to assess brain responses to socialization, both on an intra-brain and inter-brain level. Notably, the brain activation of a marmoset when viewing a second marmoset in-person versus when viewing a pre-recorded video of the same marmoset—i.e., when either capable or incapable of socially interacting with a visible conspecific—demonstrates increased activation in the face-patch network. This method enables a wide range of possibilities for potentially studying social function and dysfunction in a non-human primate model.

Suggested Citation

  • Kyle M. Gilbert & Justine C. Cléry & Joseph S. Gati & Yuki Hori & Kevin D. Johnston & Alexander Mashkovtsev & Janahan Selvanayagam & Peter Zeman & Ravi S. Menon & David J. Schaeffer & Stefan Everling, 2021. "Simultaneous functional MRI of two awake marmosets," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26976-4
    DOI: 10.1038/s41467-021-26976-4
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    References listed on IDEAS

    as
    1. Erika Sasaki & Hiroshi Suemizu & Akiko Shimada & Kisaburo Hanazawa & Ryo Oiwa & Michiko Kamioka & Ikuo Tomioka & Yusuke Sotomaru & Reiko Hirakawa & Tomoo Eto & Seiji Shiozawa & Takuji Maeda & Mamoru I, 2009. "Generation of transgenic non-human primates with germline transmission," Nature, Nature, vol. 459(7246), pages 523-527, May.
    2. Cirong Liu & Cecil Chern-Chyi Yen & Diego Szczupak & Frank Q. Ye & David A. Leopold & Afonso C. Silva, 2019. "Anatomical and functional investigation of the marmoset default mode network," Nature Communications, Nature, vol. 10(1), pages 1-8, December.
    3. David J. Schaeffer & Janahan Selvanayagam & Kevin D. Johnston & Ravi S. Menon & Winrich A. Freiwald & Stefan Everling, 2020. "Face selective patches in marmoset frontal cortex," Nature Communications, Nature, vol. 11(1), pages 1-8, December.
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