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Fully integrated silicon probes for high-density recording of neural activity

Author

Listed:
  • James J. Jun

    (HHMI Janelia Research Campus)

  • Nicholas A. Steinmetz

    (UCL Institute of Neurology, University College London
    Physiology and Pharmacology, University College London
    UCL Institute of Ophthalmology, University College London)

  • Joshua H. Siegle

    (Allen Institute for Brain Science)

  • Daniel J. Denman

    (Allen Institute for Brain Science)

  • Marius Bauza

    (University College London
    Sainsbury Wellcome Centre, University College London)

  • Brian Barbarits

    (HHMI Janelia Research Campus)

  • Albert K. Lee

    (HHMI Janelia Research Campus)

  • Costas A. Anastassiou

    (Allen Institute for Brain Science
    University of British Columbia)

  • Alexandru Andrei

    (imec, Kapeldreef 75)

  • Çağatay Aydın

    (Neuro-Electronics Research Flanders
    KU Leuven)

  • Mladen Barbic

    (HHMI Janelia Research Campus)

  • Timothy J. Blanche

    (Allen Institute for Brain Science
    White Matter LLC)

  • Vincent Bonin

    (imec, Kapeldreef 75
    Neuro-Electronics Research Flanders
    KU Leuven
    VIB)

  • João Couto

    (Neuro-Electronics Research Flanders
    KU Leuven)

  • Barundeb Dutta

    (imec, Kapeldreef 75)

  • Sergey L. Gratiy

    (Allen Institute for Brain Science)

  • Diego A. Gutnisky

    (HHMI Janelia Research Campus)

  • Michael Häusser

    (Physiology and Pharmacology, University College London
    Wolfson Institute for Biomedical Research, University College London)

  • Bill Karsh

    (HHMI Janelia Research Campus)

  • Peter Ledochowitsch

    (Allen Institute for Brain Science)

  • Carolina Mora Lopez

    (imec, Kapeldreef 75)

  • Catalin Mitelut

    (Allen Institute for Brain Science
    University of British Columbia)

  • Silke Musa

    (imec, Kapeldreef 75)

  • Michael Okun

    (UCL Institute of Neurology, University College London
    Physiology and Pharmacology, University College London
    Centre for Systems Neuroscience, University of Leicester)

  • Marius Pachitariu

    (UCL Institute of Neurology, University College London
    Physiology and Pharmacology, University College London)

  • Jan Putzeys

    (imec, Kapeldreef 75)

  • P. Dylan Rich

    (HHMI Janelia Research Campus)

  • Cyrille Rossant

    (UCL Institute of Neurology, University College London
    Physiology and Pharmacology, University College London)

  • Wei-lung Sun

    (HHMI Janelia Research Campus)

  • Karel Svoboda

    (HHMI Janelia Research Campus)

  • Matteo Carandini

    (UCL Institute of Ophthalmology, University College London)

  • Kenneth D. Harris

    (UCL Institute of Neurology, University College London
    Physiology and Pharmacology, University College London)

  • Christof Koch

    (Allen Institute for Brain Science)

  • John O’Keefe

    (University College London
    Sainsbury Wellcome Centre, University College London)

  • Timothy D. Harris

    (HHMI Janelia Research Campus)

Abstract

New silicon probes known as Neuropixels are shown to record from hundreds of neurons simultaneously in awake and freely moving rodents.

Suggested Citation

  • James J. Jun & Nicholas A. Steinmetz & Joshua H. Siegle & Daniel J. Denman & Marius Bauza & Brian Barbarits & Albert K. Lee & Costas A. Anastassiou & Alexandru Andrei & Çağatay Aydın & Mladen Barbic &, 2017. "Fully integrated silicon probes for high-density recording of neural activity," Nature, Nature, vol. 551(7679), pages 232-236, November.
    • Handle: RePEc:nat:nature:v:551:y:2017:i:7679:d:10.1038_nature24636
    DOI: 10.1038/nature24636
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    Cited by:

    1. Spencer Ward & Conor Riley & Erin M. Carey & Jenny Nguyen & Sadik Esener & Axel Nimmerjahn & Donald J. Sirbuly, 2022. "Electro-optical mechanically flexible coaxial microprobes for minimally invasive interfacing with intrinsic neural circuits," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Jasmin A. Strickland & Michael A. McDannald, 2022. "Brainstem networks construct threat probability and prediction error from neuronal building blocks," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    3. Yina Wei & Anirban Nandi & Xiaoxuan Jia & Joshua H. Siegle & Daniel Denman & Soo Yeun Lee & Anatoly Buchin & Werner Geit & Clayton P. Mosher & Shawn Olsen & Costas A. Anastassiou, 2023. "Associations between in vitro, in vivo and in silico cell classes in mouse primary visual cortex," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    4. Maximilian Hoffmann & Jörg Henninger & Johannes Veith & Lars Richter & Benjamin Judkewitz, 2023. "Blazed oblique plane microscopy reveals scale-invariant inference of brain-wide population activity," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    5. Francis Kei Masuda & Emily A. Aery Jones & Yanjun Sun & Lisa M. Giocomo, 2023. "Ketamine evoked disruption of entorhinal and hippocampal spatial maps," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    6. Jérémie Sibille & Carolin Gehr & Jonathan I. Benichov & Hymavathy Balasubramanian & Kai Lun Teh & Tatiana Lupashina & Daniela Vallentin & Jens Kremkow, 2022. "High-density electrode recordings reveal strong and specific connections between retinal ganglion cells and midbrain neurons," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    7. Ilke Uguz & David Ohayon & Volkan Arslan & Rajendar Sheelamanthula & Sophie Griggs & Adel Hama & John William Stanton & Iain McCulloch & Sahika Inal & Kenneth L. Shepard, 2024. "Flexible switch matrix addressable electrode arrays with organic electrochemical transistor and pn diode technology," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    8. Tal Sharf & Tjitse Molen & Stella M. K. Glasauer & Elmer Guzman & Alessio P. Buccino & Gabriel Luna & Zhuowei Cheng & Morgane Audouard & Kamalini G. Ranasinghe & Kiwamu Kudo & Srikantan S. Nagarajan &, 2022. "Functional neuronal circuitry and oscillatory dynamics in human brain organoids," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    9. Patrick Jendritza & Frederike J. Klein & Pascal Fries, 2023. "Multi-area recordings and optogenetics in the awake, behaving marmoset," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    10. David Eriksson & Artur Schneider & Anupriya Thirumalai & Mansour Alyahyay & Brice Crompe & Kirti Sharma & Patrick Ruther & Ilka Diester, 2022. "Multichannel optogenetics combined with laminar recordings for ultra-controlled neuronal interrogation," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    11. Keundong Lee & Angelique C. Paulk & Yun Goo Ro & Daniel R. Cleary & Karen J. Tonsfeldt & Yoav Kfir & John S. Pezaris & Youngbin Tchoe & Jihwan Lee & Andrew M. Bourhis & Ritwik Vatsyayan & Joel R. Mart, 2024. "Flexible, scalable, high channel count stereo-electrode for recording in the human brain," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    12. Peichao Li & Anupam K. Garg & Li A. Zhang & Mohammad S. Rashid & Edward M. Callaway, 2022. "Cone opponent functional domains in primary visual cortex combine signals for color appearance mechanisms," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    13. Morgan A. Brown & Kara M. Zappitelli & Loveprit Singh & Rachel C. Yuan & Melissa Bemrose & Valerie Brogden & David J. Miller & Matthew C. Smear & Stuart F. Cogan & Timothy J. Gardner, 2023. "Direct laser writing of 3D electrodes on flexible substrates," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    14. Liang Zou & Huihui Tian & Shouliang Guan & Jianfei Ding & Lei Gao & Jinfen Wang & Ying Fang, 2021. "Self-assembled multifunctional neural probes for precise integration of optogenetics and electrophysiology," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    15. Jung Min Lee & Young-Woo Pyo & Yeon Jun Kim & Jin Hee Hong & Yonghyeon Jo & Wonshik Choi & Dingchang Lin & Hong-Gyu Park, 2023. "The ultra-thin, minimally invasive surface electrode array NeuroWeb for probing neural activity," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    16. Young-Geun Park & Yong Won Kwon & Chin Su Koh & Enji Kim & Dong Ha Lee & Sumin Kim & Jongmin Mun & Yeon-Mi Hong & Sanghoon Lee & Ju-Young Kim & Jae-Hyun Lee & Hyun Ho Jung & Jinwoo Cheon & Jin Woo Cha, 2024. "In-vivo integration of soft neural probes through high-resolution printing of liquid electronics on the cranium," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    17. Bartul Mimica & Tuçe Tombaz & Claudia Battistin & Jingyi Guo Fuglstad & Benjamin A. Dunn & Jonathan R. Whitlock, 2023. "Behavioral decomposition reveals rich encoding structure employed across neocortex in rats," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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