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Visual evoked feedforward–feedback traveling waves organize neural activity across the cortical hierarchy in mice

Author

Listed:
  • Adeeti Aggarwal

    (University of Pennsylvania
    University of Pennsylvania)

  • Connor Brennan

    (University of Pennsylvania
    University of Pennsylvania)

  • Jennifer Luo

    (University of Pennsylvania)

  • Helen Chung

    (University of Pennsylvania)

  • Diego Contreras

    (University of Pennsylvania)

  • Max B. Kelz

    (University of Pennsylvania)

  • Alex Proekt

    (University of Pennsylvania)

Abstract

Sensory processing is distributed among many brain regions that interact via feedforward and feedback signaling. Neuronal oscillations have been shown to mediate intercortical feedforward and feedback interactions. Yet, the macroscopic structure of the multitude of such oscillations remains unclear. Here, we show that simple visual stimuli reliably evoke two traveling waves with spatial wavelengths that cover much of the cerebral hemisphere in awake mice. 30-50 Hz feedforward waves arise in primary visual cortex (V1) and propagate rostrally, while 3-6 Hz feedback waves originate in the association cortex and flow caudally. The phase of the feedback wave modulates the amplitude of the feedforward wave and synchronizes firing between V1 and parietal cortex. Altogether, these results provide direct experimental evidence that visual evoked traveling waves percolate through the cerebral cortex and coordinate neuronal activity across broadly distributed networks mediating visual processing.

Suggested Citation

  • Adeeti Aggarwal & Connor Brennan & Jennifer Luo & Helen Chung & Diego Contreras & Max B. Kelz & Alex Proekt, 2022. "Visual evoked feedforward–feedback traveling waves organize neural activity across the cortical hierarchy in mice," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32378-x
    DOI: 10.1038/s41467-022-32378-x
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    References listed on IDEAS

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    Cited by:

    1. Gabriel B. Benigno & Roberto C. Budzinski & Zachary W. Davis & John H. Reynolds & Lyle Muller, 2023. "Waves traveling over a map of visual space can ignite short-term predictions of sensory input," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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