IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-021-26138-6.html
   My bibliography  Save this article

Clonal hematopoiesis is associated with risk of severe Covid-19

Author

Listed:
  • Kelly L. Bolton

    (Washington University)

  • Youngil Koh

    (Seoul National University Hospital
    Genome Opinion Inc.
    Seoul National University Hospital)

  • Michael B. Foote

    (Memorial Sloan Kettering Cancer Center)

  • Hogune Im

    (Genome Opinion Inc.)

  • Justin Jee

    (Memorial Sloan Kettering Cancer Center)

  • Choong Hyun Sun

    (Genome Opinion Inc.)

  • Anton Safonov

    (Memorial Sloan Kettering Cancer Center)

  • Ryan Ptashkin

    (Memorial Sloan Kettering Cancer Center)

  • Joon Ho Moon

    (Kyungpook National University Hospital, School of Medicine, Kyungpook National University)

  • Ji Yeon Lee

    (National Medical Center)

  • Jongtak Jung

    (Seoul National University Bundang Hospital)

  • Chang Kyung Kang

    (Seoul National University Hospital)

  • Kyoung-Ho Song

    (Seoul National University Bundang Hospital)

  • Pyoeng Gyun Choe

    (Seoul National University Hospital)

  • Wan Beom Park

    (Seoul National University Hospital)

  • Hong Bin Kim

    (Seoul National University Bundang Hospital)

  • Myoung-don Oh

    (Seoul National University Hospital)

  • Han Song

    (Genome Opinion Inc.)

  • Sugyeong Kim

    (Genome Opinion Inc.)

  • Minal Patel

    (Memorial Sloan Kettering Cancer Center)

  • Andriy Derkach

    (Memorial Sloan Kettering Cancer Center)

  • Erika Gedvilaite

    (Memorial Sloan Kettering Cancer Center)

  • Kaitlyn A. Tkachuk

    (Memorial Sloan Kettering Cancer Center)

  • Brian J. Wiley

    (Washington University)

  • Ireaneus C. Chan

    (Washington University)

  • Lior Z. Braunstein

    (Memorial Sloan Kettering Cancer Center)

  • Teng Gao

    (Memorial Sloan Kettering Cancer Center)

  • Elli Papaemmanuil

    (Memorial Sloan Kettering Cancer Center)

  • N. Esther Babady

    (Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center)

  • Melissa S. Pessin

    (Memorial Sloan Kettering Cancer Center)

  • Mini Kamboj

    (Memorial Sloan Kettering Cancer Center)

  • Luis A. Diaz

    (Memorial Sloan Kettering Cancer Center)

  • Marc Ladanyi

    (Memorial Sloan Kettering Cancer Center)

  • Michael J. Rauh

    (Queen’s University)

  • Pradeep Natarajan

    (Massachusetts General Hospital
    Brigham and Women’s Hospital, Harvard Medical School)

  • Mitchell J. Machiela

    (National Cancer Institute)

  • Philip Awadalla

    (Ontario Institute for Cancer Research)

  • Vijai Joseph

    (Memorial Sloan Kettering Cancer Center)

  • Kenneth Offit

    (Memorial Sloan Kettering Cancer Center)

  • Larry Norton

    (Memorial Sloan Kettering Cancer Center)

  • Michael F. Berger

    (Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center)

  • Ross L. Levine

    (Memorial Sloan Kettering Cancer Center)

  • Eu Suk Kim

    (Seoul National University Bundang Hospital)

  • Nam Joong Kim

    (Seoul National University Hospital)

  • Ahmet Zehir

    (Memorial Sloan Kettering Cancer Center)

Abstract

Acquired somatic mutations in hematopoietic stem and progenitor cells (clonal hematopoiesis or CH) are associated with advanced age, increased risk of cardiovascular and malignant diseases, and decreased overall survival. These adverse sequelae may be mediated by altered inflammatory profiles observed in patients with CH. A pro-inflammatory immunologic profile is also associated with worse outcomes of certain infections, including SARS-CoV-2 and its associated disease Covid-19. Whether CH predisposes to severe Covid-19 or other infections is unknown. Among 525 individuals with Covid-19 from Memorial Sloan Kettering (MSK) and the Korean Clonal Hematopoiesis (KoCH) consortia, we show that CH is associated with severe Covid-19 outcomes (OR = 1.85, 95%=1.15–2.99, p = 0.01), in particular CH characterized by non-cancer driver mutations (OR = 2.01, 95% CI = 1.15–3.50, p = 0.01). We further explore the relationship between CH and risk of other infections in 14,211 solid tumor patients at MSK. CH is significantly associated with risk of Clostridium Difficile (HR = 2.01, 95% CI: 1.22–3.30, p = 6×10−3) and Streptococcus/Enterococcus infections (HR = 1.56, 95% CI = 1.15–2.13, p = 5×10−3). These findings suggest a relationship between CH and risk of severe infections that warrants further investigation.

Suggested Citation

  • Kelly L. Bolton & Youngil Koh & Michael B. Foote & Hogune Im & Justin Jee & Choong Hyun Sun & Anton Safonov & Ryan Ptashkin & Joon Ho Moon & Ji Yeon Lee & Jongtak Jung & Chang Kyung Kang & Kyoung-Ho S, 2021. "Clonal hematopoiesis is associated with risk of severe Covid-19," Nature Communications, Nature, vol. 12(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26138-6
    DOI: 10.1038/s41467-021-26138-6
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-26138-6
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-021-26138-6?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Po-Ru Loh & Giulio Genovese & Robert E. Handsaker & Hilary K. Finucane & Yakir A. Reshef & Pier Francesco Palamara & Brenda M. Birmann & Michael E. Talkowski & Samuel F. Bakhoum & Steven A. McCarroll , 2018. "Insights into clonal haematopoiesis from 8,342 mosaic chromosomal alterations," Nature, Nature, vol. 559(7714), pages 350-355, July.
    2. Viechtbauer, Wolfgang, 2010. "Conducting Meta-Analyses in R with the metafor Package," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 36(i03).
    3. Alexander G. Bick & Joshua S. Weinstock & Satish K. Nandakumar & Charles P. Fulco & Erik L. Bao & Seyedeh M. Zekavat & Mindy D. Szeto & Xiaotian Liao & Matthew J. Leventhal & Joseph Nasser & Kyle Chan, 2020. "Inherited causes of clonal haematopoiesis in 97,691 whole genomes," Nature, Nature, vol. 586(7831), pages 763-768, October.
    4. Chikashi Terao & Akari Suzuki & Yukihide Momozawa & Masato Akiyama & Kazuyoshi Ishigaki & Kazuhiko Yamamoto & Koichi Matsuda & Yoshinori Murakami & Steven A. McCarroll & Michiaki Kubo & Po-Ru Loh & Yo, 2020. "Chromosomal alterations among age-related haematopoietic clones in Japan," Nature, Nature, vol. 584(7819), pages 130-135, August.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Bart Verkuil & Serpil Atasayi & Marc L Molendijk, 2015. "Workplace Bullying and Mental Health: A Meta-Analysis on Cross-Sectional and Longitudinal Data," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-16, August.
    2. Francesca Pilotto & Ingolf Kühn & Rita Adrian & Renate Alber & Audrey Alignier & Christopher Andrews & Jaana Bäck & Luc Barbaro & Deborah Beaumont & Natalie Beenaerts & Sue Benham & David S. Boukal & , 2020. "Meta-analysis of multidecadal biodiversity trends in Europe," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    3. repec:cup:judgdm:v:15:y:2020:i:6:p:972-988 is not listed on IDEAS
    4. Jonas Schmidt & Tammo H. A. Bijmolt, 2020. "Accurately measuring willingness to pay for consumer goods: a meta-analysis of the hypothetical bias," Journal of the Academy of Marketing Science, Springer, vol. 48(3), pages 499-518, May.
    5. Mario Herberz & Tobias Brosch & Ulf J. J. Hahnel, 2020. "Kilo what? Default units increase value sensitivity in joint evaluations of energy efficiency," Judgment and Decision Making, Society for Judgment and Decision Making, vol. 15(6), pages 972-988, November.
    6. Piers Steel & Sjoerd Beugelsdijk & Herman Aguinis, 2021. "The anatomy of an award-winning meta-analysis: Recommendations for authors, reviewers, and readers of meta-analytic reviews," Journal of International Business Studies, Palgrave Macmillan;Academy of International Business, vol. 52(1), pages 23-44, February.
    7. Augusteijn, Hilde Elisabeth Maria & van Aert, Robbie Cornelis Maria & van Assen, Marcel A. L. M., 2021. "Posterior Probabilities of Effect Sizes and Heterogeneity in Meta-Analysis: An Intuitive Approach of Dealing with Publication Bias," OSF Preprints avkgj, Center for Open Science.
    8. J. McClatchy & R. Strogantsev & E. Wolfe & H. Y. Lin & M. Mohammadhosseini & B. A. Davis & C. Eden & D. Goldman & W. H. Fleming & P. Conley & G. Wu & L. Cimmino & H. Mohammed & A. Agarwal, 2023. "Clonal hematopoiesis related TET2 loss-of-function impedes IL1β-mediated epigenetic reprogramming in hematopoietic stem and progenitor cells," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    9. Shuji Ito & Xiaoxi Liu & Yuki Ishikawa & David D. Conti & Nao Otomo & Zsofia Kote-Jarai & Hiroyuki Suetsugu & Rosalind A. Eeles & Yoshinao Koike & Keiko Hikino & Soichiro Yoshino & Kohei Tomizuka & Mo, 2023. "Androgen receptor binding sites enabling genetic prediction of mortality due to prostate cancer in cancer-free subjects," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    10. Georgiou, George K. & Guo, Kan & Naveenkumar, Nithya & Vieira, Ana Paula Alves & Das, J.P., 2020. "PASS theory of intelligence and academic achievement: A meta-analytic review," Intelligence, Elsevier, vol. 79(C).
    11. Stephan Kambach & Ingolf Kühn & Bastien Castagneyrol & Helge Bruelheide, 2016. "The Impact of Tree Diversity on Different Aspects of Insect Herbivory along a Global Temperature Gradient - A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(11), pages 1-14, November.
    12. repec:cup:judgdm:v:14:y:2019:i:3:p:234-279 is not listed on IDEAS
    13. de la Cruz, Vera Ysabel V. & Tantriani, & Cheng, Weiguo & Tawaraya, Keitaro, 2023. "Yield gap between organic and conventional farming systems across climate types and sub-types: A meta-analysis," Agricultural Systems, Elsevier, vol. 211(C).
    14. Kelly R Moran & Sara Y Del Valle, 2016. "A Meta-Analysis of the Association between Gender and Protective Behaviors in Response to Respiratory Epidemics and Pandemics," PLOS ONE, Public Library of Science, vol. 11(10), pages 1-25, October.
    15. Cyrielle Maroteau & Antonio Espuela-Ortiz & Esther Herrera-Luis & Sundararajan Srinivasan & Fiona Carr & Roger Tavendale & Karen Wilson & Natalia Hernandez-Pacheco & James D Chalmers & Steve Turner & , 2021. "LTA4H rs2660845 association with montelukast response in early and late-onset asthma," PLOS ONE, Public Library of Science, vol. 16(9), pages 1-17, September.
    16. Barne Willie & Emma L. Sweeney & Steven G. Badman & Mark Chatfield & Andrew J. Vallely & Angela Kelly-Hanku & David M. Whiley, 2022. "The Prevalence of Antimicrobial Resistant Neisseria gonorrhoeae in Papua New Guinea: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 19(3), pages 1-11, January.
    17. Larney, Andrea & Rotella, Amanda & Barclay, Pat, 2019. "Stake size effects in ultimatum game and dictator game offers: A meta-analysis," Organizational Behavior and Human Decision Processes, Elsevier, vol. 151(C), pages 61-72.
    18. Blum, Diego & Holling, Heinz, 2017. "Spearman's law of diminishing returns. A meta-analysis," Intelligence, Elsevier, vol. 65(C), pages 60-66.
    19. Stephanie Medlock & Juliette L Parlevliet & Danielle Sent & Saeid Eslami & Marjan Askari & Derk L Arts & Joost B Hoekstra & Sophia E de Rooij & Ameen Abu-Hanna, 2017. "An email-based intervention to improve the number and timeliness of letters sent from the hospital outpatient clinic to the general practitioner: A pair-randomized controlled trial," PLOS ONE, Public Library of Science, vol. 12(10), pages 1-13, October.
    20. Chin Lin & Hsiang-Cheng Chen & Wen-Hui Fang & Chih-Chien Wang & Yi-Jen Peng & Herng-Sheng Lee & Hung Chang & Chi-Ming Chu & Guo-Shu Huang & Wei-Teing Chen & Yu-Jui Tsai & Hong-Ling Lin & Fu-Huang Lin , 2016. "Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism and Susceptibility to Osteoarthritis of the Knee: A Case-Control Study and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(9), pages 1-18, September.
    21. Vize, Colin E. & Miller, Joshua D. & Lynam, Donald R., 2018. "FFM facets and their relations with different forms of antisocial behavior: An expanded meta-analysis," Journal of Criminal Justice, Elsevier, vol. 57(C), pages 67-75.
    22. Evangelos Danopoulos & Maureen Twiddy & Jeanette M Rotchell, 2020. "Microplastic contamination of drinking water: A systematic review," PLOS ONE, Public Library of Science, vol. 15(7), pages 1-23, July.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26138-6. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.