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Doing Good with Good OR: Supporting Cost-Effective Hepatitis B Interventions

Author

Listed:
  • David W. Hutton

    (Department of Management Science and Engineering, Stanford University, Stanford, California 94305)

  • Margaret L. Brandeau

    (Department of Management Science and Engineering, Stanford University, Stanford, California 94305)

  • Samuel K. So

    (Asian Liver Center and Department of Surgery, Stanford University School of Medicine, Stanford, California 94305)

Abstract

In an era of limited health-care budgets, mathematical models can be useful tools to identify cost-effective programs and support policy makers in making informed decisions. This paper reports the results of our work, which we carried out over several years with the Asian Liver Center at Stanford University. Hepatitis B is a vaccine-preventable viral disease that, if untreated, can lead to death from cirrhosis and liver cancer. It is a major public health problem, particularly in Asian populations. We used new combinations of decision analysis and Markov models to analyze the cost effectiveness of several interventions to combat the disease in the United States and China. The results of our operations research (OR)-based analyses have helped change US public health policy on hepatitis B screening for millions of people, and have helped encourage policy makers in China to enact legislation to provide free catch-up vaccination for hundreds of millions of children. These policies are an important step in eliminating health disparities, reducing discrimination, and ensuring that millions of people can now receive the hepatitis B vaccination or life-saving treatment that they need.

Suggested Citation

  • David W. Hutton & Margaret L. Brandeau & Samuel K. So, 2011. "Doing Good with Good OR: Supporting Cost-Effective Hepatitis B Interventions," Interfaces, INFORMS, vol. 41(3), pages 289-300, June.
    • Handle: RePEc:inm:orinte:v:41:y:2011:i:3:p:289-300
    DOI: 10.1287/inte.1100.0511
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    References listed on IDEAS

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    1. James G. Kahn & Margaret L. Brandeau & John Dunn-Mortimer, 1998. "OR Modeling and AIDS Policy: From Theory to Practice," Interfaces, INFORMS, vol. 28(3), pages 3-22, June.
    2. McQuillan, G.M. & Coleman, P.J. & Kruszon-Moran, D. & Moyer, L.A. & Lambert, S.B. & Margolis, H.S., 1999. "Prevalence of hepatitis B virus infection in the United States: The National Health and Nutrition Examination Surveys, 1976 through 1994," American Journal of Public Health, American Public Health Association, vol. 89(1), pages 14-18.
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    Cited by:

    1. Duijzer, Lotty Evertje & van Jaarsveld, Willem & Dekker, Rommert, 2018. "Literature review: The vaccine supply chain," European Journal of Operational Research, Elsevier, vol. 268(1), pages 174-192.
    2. Guihua Wang & Jun Li & Wallace J. Hopp & Franco L. Fazzalari & Steven F. Bolling, 2019. "Using Patient-Specific Quality Information to Unlock Hidden Healthcare Capabilities," Manufacturing & Service Operations Management, INFORMS, vol. 21(3), pages 582-601, July.
    3. Margaret L. Brandeau, 2016. "Creating impact with operations research in health: making room for practice in academia," Health Care Management Science, Springer, vol. 19(4), pages 305-312, December.

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