IDEAS home Printed from https://ideas.repec.org/a/ibn/masjnl/v5y2011i3p103.html
   My bibliography  Save this article

Parametric Estimation of the Cure Fraction Based on BCH Model Using Left-Censored Data with Covariates

Author

Listed:
  • Bader Aljawadi
  • Mohd Rizam A. Bakar
  • Noor Akma Ibrahim
  • Habshah Midi

Abstract

Medical investigations nowadays allow the incorporation of cure individuals in the analysis, especially for chronic diseases such as cancer. Therefore, survival models that incorporate the cured patients in the analysis are called cure rate models. In this paper, we propose an analytical approach for parametric estimation of the cure fraction in cancer clinical trials based on the bounded cumulative hazard (BCH) model with covariates involved in the data set. The analysis is constructed by means of the exponential distribution in the case of left censoring and within the framework of the expectation maximization (EM) algorithm. The analysis provided an analytical solution for the estimation equations of the cure rate parameter.

Suggested Citation

  • Bader Aljawadi & Mohd Rizam A. Bakar & Noor Akma Ibrahim & Habshah Midi, 2011. "Parametric Estimation of the Cure Fraction Based on BCH Model Using Left-Censored Data with Covariates," Modern Applied Science, Canadian Center of Science and Education, vol. 5(3), pages 103-103, June.
    • Handle: RePEc:ibn:masjnl:v:5:y:2011:i:3:p:103
    as

    Download full text from publisher

    File URL: https://ccsenet.org/journal/index.php/mas/article/download/9616/7733
    Download Restriction: no
    File URL: https://ccsenet.org/journal/index.php/mas/article/view/9616
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Rodrigues, Josemar & Cancho, Vicente G. & de Castro, Mrio & Louzada-Neto, Francisco, 2009. "On the unification of long-term survival models," Statistics & Probability Letters, Elsevier, vol. 79(6), pages 753-759, March.
    2. Judy P. Sy & Jeremy M. G. Taylor, 2000. "Estimation in a Cox Proportional Hazards Cure Model," Biometrics, The International Biometric Society, vol. 56(1), pages 227-236, March.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Amanda D’Andrea & Ricardo Rocha & Vera Tomazella & Francisco Louzada, 2018. "Negative Binomial Kumaraswamy-G Cure Rate Regression Model," JRFM, MDPI, vol. 11(1), pages 1-14, January.
    2. Elizabeth Hashimoto & Gauss Cordeiro & Edwin Ortega, 2013. "The new Neyman type A beta Weibull model with long-term survivors," Computational Statistics, Springer, vol. 28(3), pages 933-954, June.
    3. Rocha, Ricardo & Nadarajah, Saralees & Tomazella, Vera & Louzada, Francisco, 2017. "A new class of defective models based on the Marshall–Olkin family of distributions for cure rate modeling," Computational Statistics & Data Analysis, Elsevier, vol. 107(C), pages 48-63.
    4. N. Balakrishnan & M. V. Koutras & F. S. Milienos & S. Pal, 2016. "Piecewise Linear Approximations for Cure Rate Models and Associated Inferential Issues," Methodology and Computing in Applied Probability, Springer, vol. 18(4), pages 937-966, December.
    5. Balakrishnan, N. & Pal, Suvra, 2013. "Lognormal lifetimes and likelihood-based inference for flexible cure rate models based on COM-Poisson family," Computational Statistics & Data Analysis, Elsevier, vol. 67(C), pages 41-67.
    6. Carvalho Lopes, Celia Mendes & Bolfarine, Heleno, 2012. "Random effects in promotion time cure rate models," Computational Statistics & Data Analysis, Elsevier, vol. 56(1), pages 75-87, January.
    7. Narisetty, Naveen & Koenker, Roger, 2022. "Censored quantile regression survival models with a cure proportion," Journal of Econometrics, Elsevier, vol. 226(1), pages 192-203.
    8. Scolas, Sylvie & Legrand, Catherine & Oulhaj, Abderrahim & El Ghouch, Anouar, 2016. "Diagnostic checks in mixture cure models with interval-censoring," LIDAM Discussion Papers ISBA 2016014, Université catholique de Louvain, Institute of Statistics, Biostatistics and Actuarial Sciences (ISBA).
    9. Bremhorst, Vincent & Lambert, Philippe, 2013. "Flexible estimation in cure survival models using Bayesian P-splines," LIDAM Discussion Papers ISBA 2013039, Université catholique de Louvain, Institute of Statistics, Biostatistics and Actuarial Sciences (ISBA).
    10. Suvra Pal & N. Balakrishnan, 2017. "Likelihood inference for the destructive exponentially weighted Poisson cure rate model with Weibull lifetime and an application to melanoma data," Computational Statistics, Springer, vol. 32(2), pages 429-449, June.
    11. Xu, Linzhi & Zhang, Jiajia, 2010. "Multiple imputation method for the semiparametric accelerated failure time mixture cure model," Computational Statistics & Data Analysis, Elsevier, vol. 54(7), pages 1808-1816, July.
    12. Dirick, Lore & Claeskens, Gerda & Vasnev, Andrey & Baesens, Bart, 2022. "A hierarchical mixture cure model with unobserved heterogeneity for credit risk," Econometrics and Statistics, Elsevier, vol. 22(C), pages 39-55.
    13. Dirick, Lore & Claeskens, Gerda & Baesens, Bart, 2015. "An Akaike information criterion for multiple event mixture cure models," European Journal of Operational Research, Elsevier, vol. 241(2), pages 449-457.
    14. Chen, Chyong-Mei & Lu, Tai-Fang C., 2012. "Marginal analysis of multivariate failure time data with a surviving fraction based on semiparametric transformation cure models," Computational Statistics & Data Analysis, Elsevier, vol. 56(3), pages 645-655.
    15. David Todem & Wei‐Wen Hsu & KyungMann Kim, 2023. "Nonparametric scanning tests of homogeneity for hierarchical models with continuous covariates," Biometrics, The International Biometric Society, vol. 79(3), pages 2063-2075, September.
    16. Vicente G. Cancho & Márcia A. C. Macera & Adriano K. Suzuki & Francisco Louzada & Katherine E. C. Zavaleta, 2020. "A new long-term survival model with dispersion induced by discrete frailty," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 26(2), pages 221-244, April.
    17. Guoqing Diao & Ao Yuan, 2019. "A class of semiparametric cure models with current status data," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 25(1), pages 26-51, January.
    18. Ana López-Cheda & Yingwei Peng & María Amalia Jácome, 2023. "Nonparametric estimation in mixture cure models with covariates," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 32(2), pages 467-495, June.
    19. Borges, Patrick & Rodrigues, Josemar & Balakrishnan, Narayanaswamy, 2012. "Correlated destructive generalized power series cure rate models and associated inference with an application to a cutaneous melanoma data," Computational Statistics & Data Analysis, Elsevier, vol. 56(6), pages 1703-1713.
    20. Li, Chin-Shang & Taylor, Jeremy M. G. & Sy, Judy P., 2001. "Identifiability of cure models," Statistics & Probability Letters, Elsevier, vol. 54(4), pages 389-395, October.

    More about this item

    JEL classification:

    • R00 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General - - - General
    • Z0 - Other Special Topics - - General

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:ibn:masjnl:v:5:y:2011:i:3:p:103. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Canadian Center of Science and Education (email available below). General contact details of provider: https://edirc.repec.org/data/cepflch.html .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.