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Likelihood inference for the destructive exponentially weighted Poisson cure rate model with Weibull lifetime and an application to melanoma data

Author

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  • Suvra Pal

    (University of Texas at Arlington)

  • N. Balakrishnan

    (McMaster University)

Abstract

In this paper, we develop the steps of the expectation maximization algorithm (EM algorithm) for the determination of the maximum likelihood estimates (MLEs) of the parameters of the destructive exponentially weighted Poisson cure rate model in which the lifetimes are assumed to be Weibull. This model is more flexible than the promotion time cure rate model as it provides an interesting and realistic interpretation of the biological mechanism of the occurrence of an event of interest by including a destructive process of the initial number of causes in a competitive scenario. The standard errors of the MLEs are obtained by inverting the observed information matrix. An extensive Monte Carlo simulation study is carried out to evaluate the performance of the developed method of estimation. Finally, a known melanoma data are analyzed to illustrate the method of inference developed here. With these data, a comparison is also made with the scenario when the destructive mechanism is not included in the analysis.

Suggested Citation

  • Suvra Pal & N. Balakrishnan, 2017. "Likelihood inference for the destructive exponentially weighted Poisson cure rate model with Weibull lifetime and an application to melanoma data," Computational Statistics, Springer, vol. 32(2), pages 429-449, June.
    • Handle: RePEc:spr:compst:v:32:y:2017:i:2:d:10.1007_s00180-016-0660-8
    DOI: 10.1007/s00180-016-0660-8
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    References listed on IDEAS

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    1. N. Balakrishnan & Suvra Pal, 2015. "An EM algorithm for the estimation of parameters of a flexible cure rate model with generalized gamma lifetime and model discrimination using likelihood- and information-based methods," Computational Statistics, Springer, vol. 30(1), pages 151-189, March.
    2. Judy P. Sy & Jeremy M. G. Taylor, 2000. "Estimation in a Cox Proportional Hazards Cure Model," Biometrics, The International Biometric Society, vol. 56(1), pages 227-236, March.
    3. N. Balakrishnan & M. V. Koutras & F. S. Milienos & S. Pal, 2016. "Piecewise Linear Approximations for Cure Rate Models and Associated Inferential Issues," Methodology and Computing in Applied Probability, Springer, vol. 18(4), pages 937-966, December.
    4. Li, Chin-Shang & Taylor, Jeremy M. G. & Sy, Judy P., 2001. "Identifiability of cure models," Statistics & Probability Letters, Elsevier, vol. 54(4), pages 389-395, October.
    5. Cooner, Freda & Banerjee, Sudipto & Carlin, Bradley P. & Sinha, Debajyoti, 2007. "Flexible Cure Rate Modeling Under Latent Activation Schemes," Journal of the American Statistical Association, American Statistical Association, vol. 102, pages 560-572, June.
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    Citations

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    Cited by:

    1. Suvra Pal & Souvik Roy, 2021. "On the estimation of destructive cure rate model: A new study with exponentially weighted Poisson competing risks," Statistica Neerlandica, Netherlands Society for Statistics and Operations Research, vol. 75(3), pages 324-342, August.

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