Classification of Alzheimer’s Disease and Mild-Cognitive Impairment Base on High-Order Dynamic Functional Connectivity at Different Frequency Band

Functional brain connectivity networks obtained from resting-state functional magnetic resonance imaging (rs-fMRI) have been extensively utilized for the diagnosis of Alzheimer’s disease (AD). However, the traditional correlation analysis technique only explores the pairwise relation, which may not be suitable for revealing sufficient and proper functional connectivity links among brain regions. Additionally, previous literature typically focuses on only lower-order dynamics, without considering higher-order dynamic networks properties, and they particularly focus on single frequency range time series of rs-fMRI. To solve these problems, in this article, a new diagnosis scheme is proposed by constructing a high-order dynamic functional network at different frequency level time series (full-band (0.01–0.08 Hz); slow-4 (0.027–0.08 Hz); and slow-5 (0.01–0.027 Hz)) data obtained from rs-fMRI to build the functional brain network for all brain regions. Especially, to tune the precise analysis of the regularized parameters in the Support Vector Machine (SVM), a nested leave-one-out cross-validation (LOOCV) technique is adopted. Finally, the SVM classifier is trained to classify AD from HC based on these higher-order dynamic functional brain networks at different frequency ranges. The experiment results illustrate that for all bands with a LOOCV classification accuracy of 94.10% with a 90.95% of sensitivity, and a 96.75% of specificity outperforms the individual networks. Utilization of the given technique for the identification of AD from HC compete for the most state-of-the-art technology in terms of the diagnosis accuracy. Additionally, results obtained for the all-band shows performance further suggest that our proposed scheme has a high-rate accuracy. These results have validated the effectiveness of the proposed methods for clinical value to the identification of AD.