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HIPTox—Hazard Identification Platform to Assess the Health Impacts from Indoor and Outdoor Air Pollutant Exposures, through Mechanistic Toxicology: A Single-Centre Double-Blind Human Exposure Trial Protocol

Author

Listed:
  • Thomas Faherty

    (School of Geography, Earth and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    These authors contributed equally to this work.)

  • Huda Badri

    (Division of Infection, Immunity and Respiratory Medicine, University of Manchester, 2nd Floor Education and Research Centre, Wythenshawe Hospital, Southmoor Rd., Manchester M23 9LT, UK
    Manchester University NHS Foundation Trust, Manchester M13 9WL, UK
    These authors contributed equally to this work.)

  • Dawei Hu

    (Centre for Atmospheric Sciences, Department of Earth and Environmental Science, School of Natural Sciences, University of Manchester, Manchester M13 9PL, UK)

  • Aristeidis Voliotis

    (Centre for Atmospheric Sciences, Department of Earth and Environmental Science, School of Natural Sciences, University of Manchester, Manchester M13 9PL, UK
    National Centre for Atmospheric Science, Department of Earth and Environmental Science, University of Manchester, Manchester M13 9PL, UK)

  • Francis D. Pope

    (School of Geography, Earth and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK)

  • Ian Mudway

    (MRC Centre for Environment and Health, Imperial College London, London W12 0BZ, UK
    NIHR Health Protection Research Unit in Environmental Exposures and Health, Imperial College London, London W12 0BZ, UK
    NIHR Health Protection Research Unit in Chemical and Radiation Threats and Hazards, Imperial College London, London W12 0BZ, UK)

  • Jacky Smith

    (Division of Infection, Immunity and Respiratory Medicine, University of Manchester, 2nd Floor Education and Research Centre, Wythenshawe Hospital, Southmoor Rd., Manchester M23 9LT, UK
    Manchester University NHS Foundation Trust, Manchester M13 9WL, UK)

  • Gordon McFiggans

    (Centre for Atmospheric Sciences, Department of Earth and Environmental Science, School of Natural Sciences, University of Manchester, Manchester M13 9PL, UK)

Abstract

Over the past decade, our understanding of the impact of air pollution on short- and long-term population health has advanced considerably, focusing on adverse effects on cardiovascular and respiratory systems. There is, however, increasing evidence that air pollution exposures affect cognitive function, particularly in susceptible groups. Our study seeks to assess and hazard rank the cognitive effects of prevalent indoor and outdoor pollutants through a single-centre investigation on the cognitive functioning of healthy human volunteers aged 50 and above with a familial predisposition to dementia. Participants will all undertake five sequential controlled exposures. The sources of the air pollution exposures are wood smoke, diesel exhaust, cleaning products, and cooking emissions, with clean air serving as the control. Pre- and post-exposure spirometry, nasal lavage, blood sampling, and cognitive assessments will be performed. Repeated testing pre and post exposure to controlled levels of pollutants will allow for the identification of acute changes in functioning as well as the detection of peripheral markers of neuroinflammation and neuronal toxicity. This comprehensive approach enables the identification of the most hazardous components in indoor and outdoor air pollutants and further understanding of the pathways contributing to neurodegenerative diseases. The results of this project have the potential to facilitate greater refinement in policy, emphasizing health-relevant pollutants and providing details to aid mitigation against pollutant-associated health risks.

Suggested Citation

  • Thomas Faherty & Huda Badri & Dawei Hu & Aristeidis Voliotis & Francis D. Pope & Ian Mudway & Jacky Smith & Gordon McFiggans, 2024. "HIPTox—Hazard Identification Platform to Assess the Health Impacts from Indoor and Outdoor Air Pollutant Exposures, through Mechanistic Toxicology: A Single-Centre Double-Blind Human Exposure Trial Pr," IJERPH, MDPI, vol. 21(3), pages 1-18, February.
    • Handle: RePEc:gam:jijerp:v:21:y:2024:i:3:p:284-:d:1348652
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    References listed on IDEAS

    as
    1. Harvey, Lewis O., 1992. "The critical operating characteristic and the evaluation of expert judgment," Organizational Behavior and Human Decision Processes, Elsevier, vol. 53(2), pages 229-251, November.
    2. Matthew Botvinick & Leigh E. Nystrom & Kate Fissell & Cameron S. Carter & Jonathan D. Cohen, 1999. "Conflict monitoring versus selection-for-action in anterior cingulate cortex," Nature, Nature, vol. 402(6758), pages 179-181, November.
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