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Associations between Short-Term Air Pollution Exposure and the Peripheral Leukocyte Distribution in the Adult Male Population in Beijing, China

Author

Listed:
  • Yuting Xue

    (Department of Laboratory Medicine, Peking University Third Hospital, Beijing 100191, China
    These authors contributed equally to this work.)

  • Ji Cong

    (Department of Laboratory Medicine, Peking University Third Hospital, Beijing 100191, China
    These authors contributed equally to this work.)

  • Yi Bai

    (Department of Epidemiology, School of Public Health, Peking University, Beijing 100191, China)

  • Pai Zheng

    (Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China)

  • Guiping Hu

    (Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China
    School of Medical Science and Engineering, Beihang University, Beijing 100191, China
    Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beihang University, Beijing 100191, China)

  • Yulin Kang

    (Institute of Environmental Information, Chinese Research Academy of Environmental Sciences, Beijing 100012, China)

  • Yonghua Wu

    (Department of Laboratory Medicine, Peking University Third Hospital, Beijing 100191, China)

  • Liyan Cui

    (Department of Laboratory Medicine, Peking University Third Hospital, Beijing 100191, China)

  • Guang Jia

    (Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China)

  • Tiancheng Wang

    (Department of Laboratory Medicine, Peking University Third Hospital, Beijing 100191, China)

Abstract

The inflammatory effects of air pollution exposure may account for increased public health risk. However, evidence regarding the effects of air pollution on peripheral blood leukocytes in the population is inconsistent. We investigated the association between the short-term effects of ambient air pollution and the peripheral blood leukocyte distribution in adult men in Beijing, China. From January 2015 to December 2019, a total of 11,035 men aged 22–45 years in Beijing were included in the study. Their peripheral blood routine parameters were measured. The ambient pollution monitoring parameters (particulate matter ≤ 10 µm (PM 10 ), PM 2.5 , nitrogen dioxide (NO 2 ), sulfur dioxide (SO 2 ), carbon monoxide (CO), and ozone (O 3 )) were collected daily. The potential association between ambient air pollution exposure and peripheral blood leukocyte count and classification was analyzed with generalized additive models (GAMs). After adjusting for confounding factors, PM 2.5 , PM 10 , SO 2 , NO 2 , O 3 , and CO were significantly correlated with changes to at least one peripheral leukocyte subtype. Short-term and cumulative air pollutant exposure dramatically increased the participants’ peripheral blood neutrophil, lymphocyte, and monocyte numbers and decreased eosinophils and basophils. Our results demonstrated that air pollution induced inflammation in the participants. The peripheral leukocyte count and classification can be utilized to evaluate the inflammation induced by air pollution in the exposed male population.

Suggested Citation

  • Yuting Xue & Ji Cong & Yi Bai & Pai Zheng & Guiping Hu & Yulin Kang & Yonghua Wu & Liyan Cui & Guang Jia & Tiancheng Wang, 2023. "Associations between Short-Term Air Pollution Exposure and the Peripheral Leukocyte Distribution in the Adult Male Population in Beijing, China," IJERPH, MDPI, vol. 20(6), pages 1-14, March.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:6:p:4695-:d:1089842
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    References listed on IDEAS

    as
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    3. Mona Elbarbary & Artem Oganesyan & Trenton Honda & Geoffrey Morgan & Yuming Guo & Yanfei Guo & Joel Negin, 2021. "Systemic Inflammation (C-Reactive Protein) in Older Chinese Adults Is Associated with Long-Term Exposure to Ambient Air Pollution," IJERPH, MDPI, vol. 18(6), pages 1-15, March.
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