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Systemic Inflammation (C-Reactive Protein) in Older Chinese Adults Is Associated with Long-Term Exposure to Ambient Air Pollution

Author

Listed:
  • Mona Elbarbary

    (Faculty of Medicine and Health, Sydney School of Public Health, The University of Sydney, Sydney, NSW 2006, Australia)

  • Artem Oganesyan

    (Department of Hematology and Transfusion Medicine, National Institute of Health, Yerevan 0051, Armenia)

  • Trenton Honda

    (Bouvé College of Health Sciences, Northeastern University, Boston, MA 02115, USA)

  • Geoffrey Morgan

    (Faculty of Medicine and Health, Sydney School of Public Health, The University of Sydney, Sydney, NSW 2006, Australia
    School of Public Health, University Centre for Rural Health, The University of Sydney, Sydney, NSW 2006, Australia)

  • Yuming Guo

    (Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Clayton, VIC 3800, Australia)

  • Yanfei Guo

    (Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China)

  • Joel Negin

    (Faculty of Medicine and Health, Sydney School of Public Health, The University of Sydney, Sydney, NSW 2006, Australia)

Abstract

There is an established association between air pollution and cardiovascular disease (CVD), which is likely to be mediated by systemic inflammation. The present study evaluated links between long-term exposure to ambient air pollution and high-sensitivity C reactive protein (hs-CRP) in an older Chinese adult cohort ( n = 7915) enrolled in the World Health Organization (WHO) study on global aging and adult health (SAGE) China Wave 1 in 2008–2010. Multilevel linear and logistic regression models were used to assess the associations of particulate matter (PM) and nitrogen dioxide (NO 2 ) on log-transformed hs-CRP levels and odds ratios of CVD risk derived from CRP levels adjusted for confounders. A satellite-based spatial statistical model was applied to estimate the average community exposure to outdoor air pollutants (PM with an aerodynamic diameter of 10 μm or less (PM 10 ), 2.5 μm or less (PM 2.5 ), and 1 μm or less (PM 1 ) and NO 2 ) for each participant of the study. hs-CRP levels were drawn from dried blood spots of each participant. Each 10 μg/m 3 increment in PM 10 , PM 2.5 , PM 1 , and NO 2 was associated with 12.8% (95% confidence interval; (CI): 9.1, 16.6), 15.7% (95% CI: 10.9, 20.8), 10.2% (95% CI: 7.3, 13.2), and 11.8% (95% CI: 7.9, 15.8) higher serum levels of hs-CRP, respectively. Our findings suggest that air pollution may be an important factor in increasing systemic inflammation in older Chinese adults.

Suggested Citation

  • Mona Elbarbary & Artem Oganesyan & Trenton Honda & Geoffrey Morgan & Yuming Guo & Yanfei Guo & Joel Negin, 2021. "Systemic Inflammation (C-Reactive Protein) in Older Chinese Adults Is Associated with Long-Term Exposure to Ambient Air Pollution," IJERPH, MDPI, vol. 18(6), pages 1-15, March.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:6:p:3258-:d:521615
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    References listed on IDEAS

    as
    1. Mona Elbarbary & Trenton Honda & Geoffrey Morgan & Yuming Guo & Yanfei Guo & Paul Kowal & Joel Negin, 2020. "Ambient Air Pollution Exposure Association with Anaemia Prevalence and Haemoglobin Levels in Chinese Older Adults," IJERPH, MDPI, vol. 17(9), pages 1-15, May.
    2. Pier Mannuccio Mannucci & Massimo Franchini, 2017. "Health Effects of Ambient Air Pollution in Developing Countries," IJERPH, MDPI, vol. 14(9), pages 1-8, September.
    3. Wenling Liu & Ziping Xu & Tianan Yang, 2018. "Health Effects of Air Pollution in China," IJERPH, MDPI, vol. 15(7), pages 1-15, July.
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    1. Yian Zhang & Rebecca Rosen & Joan Reibman & Yongzhao Shao, 2022. "Posttraumatic Stress Disorder Mediates the Association between Traumatic World Trade Center Dust Cloud Exposure and Ongoing Systemic Inflammation in Community Members," IJERPH, MDPI, vol. 19(14), pages 1-16, July.
    2. Ji Hyun Kim & Hae Dong Woo & Sunho Choi & Dae Sub Song & Jung Hyun Lee & Kyoungho Lee, 2022. "Long-Term Effects of Ambient Particulate and Gaseous Pollutants on Serum High-Sensitivity C-Reactive Protein Levels: A Cross-Sectional Study Using KoGES-HEXA Data," IJERPH, MDPI, vol. 19(18), pages 1-19, September.
    3. Yuting Xue & Ji Cong & Yi Bai & Pai Zheng & Guiping Hu & Yulin Kang & Yonghua Wu & Liyan Cui & Guang Jia & Tiancheng Wang, 2023. "Associations between Short-Term Air Pollution Exposure and the Peripheral Leukocyte Distribution in the Adult Male Population in Beijing, China," IJERPH, MDPI, vol. 20(6), pages 1-14, March.

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