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Cognitive Function among World Trade Center-Exposed Community Members with Mental Health Symptoms

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  • Rebecca Rosen

    (Department of Psychiatry, NYU Grossman School of Medicine, New York, NY 10016, USA
    World Trade Center Environmental Health Center, NYC Health+Hospitals, New York, NY 10016, USA)

  • Yongzhao Shao

    (World Trade Center Environmental Health Center, NYC Health+Hospitals, New York, NY 10016, USA
    Department of Environmental Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA
    Department of Population Health, NYU Grossman School of Medicine, New York, NY 10016, USA
    NYU Alzheimer’s Disease Research Center, New York, NY 10016, USA)

  • Qiao Zhang

    (World Trade Center Environmental Health Center, NYC Health+Hospitals, New York, NY 10016, USA
    Department of Population Health, NYU Grossman School of Medicine, New York, NY 10016, USA)

  • Jia Bao

    (World Trade Center Environmental Health Center, NYC Health+Hospitals, New York, NY 10016, USA
    Department of Population Health, NYU Grossman School of Medicine, New York, NY 10016, USA)

  • Yian Zhang

    (World Trade Center Environmental Health Center, NYC Health+Hospitals, New York, NY 10016, USA
    Department of Population Health, NYU Grossman School of Medicine, New York, NY 10016, USA)

  • Arjun Masurkar

    (NYU Alzheimer’s Disease Research Center, New York, NY 10016, USA
    Department of Neurology, NYU Grossman School of Medicine, New York, NY 10016, USA)

  • Thomas Wisniewski

    (NYU Alzheimer’s Disease Research Center, New York, NY 10016, USA
    Department of Neurology, NYU Grossman School of Medicine, New York, NY 10016, USA)

  • Nina Urban

    (Department of Psychiatry, NYU Grossman School of Medicine, New York, NY 10016, USA
    World Trade Center Environmental Health Center, NYC Health+Hospitals, New York, NY 10016, USA)

  • Joan Reibman

    (World Trade Center Environmental Health Center, NYC Health+Hospitals, New York, NY 10016, USA
    Department of Environmental Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA
    Department of Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA)

Abstract

The World Trade Center Environmental Health Center (WTC EHC), is a federally designated clinical center of excellence for surveillance and treatment of WTC disaster exposed community members (WTC Survivors). Cognitive impairment (CI) has been extensively described in WTC responders and a concern for progressive impairment in all WTC disaster exposed groups has been raised. Cognitive status, however, has not been systematically characterized in the WTC Survivor population. We describe cognitive status in a subgroup of the Survivor population referred for mental health evaluation (N = 480) in the WTC EHC as measured by scores on the Montreal Cognitive Assessment (MoCA) instrument, and examine their association with WTC exposures and individual-level covariates including PTSD and depression screening inventory scores. In regression analyses, probable cognitive impairment (MoCA score < 26) was found in 59% of the study subjects and was significantly associated with age, race/ethnicity, education, income, depression and PTSD scores. Being caught in the dust cloud on 11 September 2011 was significantly associated with cognitive impairment even after controlling for the above. These data suggest an association with cognitive dysfunction in WTC Survivors with exposure to the toxic dust/fumes and psychological stress from the 9/11 terrorist attack and warrant further systematic study.

Suggested Citation

  • Rebecca Rosen & Yongzhao Shao & Qiao Zhang & Jia Bao & Yian Zhang & Arjun Masurkar & Thomas Wisniewski & Nina Urban & Joan Reibman, 2022. "Cognitive Function among World Trade Center-Exposed Community Members with Mental Health Symptoms," IJERPH, MDPI, vol. 19(6), pages 1-13, March.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:6:p:3440-:d:771181
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    References listed on IDEAS

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    1. Kacie Seil & Shengchao Yu & Howard Alper, 2019. "A Cognitive Reserve and Social Support-Focused Latent Class Analysis to Predict Self-Reported Confusion or Memory Loss among Middle-Aged World Trade Center Health Registry Enrollees," IJERPH, MDPI, vol. 16(8), pages 1-12, April.
    2. Howard E. Alper & Rifat A. Tuly & Kacie Seil & Jennifer Brite, 2020. "Post-9/11 Mental Health Comorbidity Predicts Self-Reported Confusion or Memory Loss in World Trade Center Health Registry Enrollees," IJERPH, MDPI, vol. 17(19), pages 1-11, October.
    3. Yongzhao Shao & Nedim Durmus & Yian Zhang & Sultan Pehlivan & Maria-Elena Fernandez-Beros & Lisette Umana & Rachel Corona & Adrienne Addessi & Sharon A. Abbott & Sheila Smyth-Giambanco & Alan A. Arsla, 2021. "The Development of a WTC Environmental Health Center Pan-Cancer Database," IJERPH, MDPI, vol. 18(4), pages 1-18, February.
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    5. Rebecca Rosen & Zhaoyin Zhu & Yongzhao Shao & Mengling Liu & Jia Bao & Nomi Levy-Carrick & Joan Reibman, 2019. "Longitudinal Change of PTSD Symptoms in Community Members after the World Trade Center Destruction," IJERPH, MDPI, vol. 16(7), pages 1-12, April.
    6. Ankura Singh & Rachel Zeig-Owens & Laura Rabin & Theresa Schwartz & Mayris P. Webber & David Appel & David J. Prezant & Charles B. Hall, 2020. "PTSD and Depressive Symptoms as Potential Mediators of the Association between World Trade Center Exposure and Subjective Cognitive Concerns in Rescue/Recovery Workers," IJERPH, MDPI, vol. 17(16), pages 1-13, August.
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    8. Yongzhao Shao & Yian Zhang & Mengling Liu & Maria-Elena Fernandez-Beros & Meng Qian & Joan Reibman, 2020. "Gene-Environment Interaction between the IL1RN Variants and Childhood Environmental Tobacco Smoke Exposure in Asthma Risk," IJERPH, MDPI, vol. 17(6), pages 1-16, March.
    9. Nedim Durmus & Yongzhao Shao & Alan A. Arslan & Yian Zhang & Sultan Pehlivan & Maria-Elena Fernandez-Beros & Lisette Umana & Rachel Corona & Sheila Smyth-Giambanco & Sharon A. Abbott & Joan Reibman, 2020. "Characteristics of Cancer Patients in the World Trade Center Environmental Health Center," IJERPH, MDPI, vol. 17(19), pages 1-15, October.
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    Cited by:

    1. Yian Zhang & Rebecca Rosen & Joan Reibman & Yongzhao Shao, 2022. "Posttraumatic Stress Disorder Mediates the Association between Traumatic World Trade Center Dust Cloud Exposure and Ongoing Systemic Inflammation in Community Members," IJERPH, MDPI, vol. 19(14), pages 1-16, July.
    2. Gabriele Grunig & Nedim Durmus & Yian Zhang & Yuting Lu & Sultan Pehlivan & Yuyan Wang & Kathleen Doo & Maria L. Cotrina-Vidal & Roberta Goldring & Kenneth I. Berger & Mengling Liu & Yongzhao Shao & J, 2022. "Molecular Clustering Analysis of Blood Biomarkers in World Trade Center Exposed Community Members with Persistent Lower Respiratory Symptoms," IJERPH, MDPI, vol. 19(13), pages 1-18, July.

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