IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i13p8102-d853945.html
   My bibliography  Save this article

Molecular Clustering Analysis of Blood Biomarkers in World Trade Center Exposed Community Members with Persistent Lower Respiratory Symptoms

Author

Listed:
  • Gabriele Grunig

    (Department of Environmental Medicine, New York University Grossman School of Medicine, New York, NY 10010, USA
    Division of Pulmonary Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA)

  • Nedim Durmus

    (Division of Pulmonary Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA
    World Trade Center Environmental Health Center, NYC Health + Hospitals, New York, NY 10016, USA)

  • Yian Zhang

    (World Trade Center Environmental Health Center, NYC Health + Hospitals, New York, NY 10016, USA
    Division of Biostatistics, Department of Population Health, New York University Grossman School of Medicine, New York, NY 10016, USA)

  • Yuting Lu

    (World Trade Center Environmental Health Center, NYC Health + Hospitals, New York, NY 10016, USA
    Division of Biostatistics, Department of Population Health, New York University Grossman School of Medicine, New York, NY 10016, USA)

  • Sultan Pehlivan

    (Division of Pulmonary Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA)

  • Yuyan Wang

    (World Trade Center Environmental Health Center, NYC Health + Hospitals, New York, NY 10016, USA
    Division of Biostatistics, Department of Population Health, New York University Grossman School of Medicine, New York, NY 10016, USA)

  • Kathleen Doo

    (Pulmonary, Kaiser Permanente East Bay, Oakland, CA 94611, USA)

  • Maria L. Cotrina-Vidal

    (Division of Pulmonary Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA)

  • Roberta Goldring

    (Division of Pulmonary Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA)

  • Kenneth I. Berger

    (Division of Pulmonary Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA)

  • Mengling Liu

    (World Trade Center Environmental Health Center, NYC Health + Hospitals, New York, NY 10016, USA
    Division of Biostatistics, Department of Population Health, New York University Grossman School of Medicine, New York, NY 10016, USA)

  • Yongzhao Shao

    (Department of Environmental Medicine, New York University Grossman School of Medicine, New York, NY 10010, USA
    World Trade Center Environmental Health Center, NYC Health + Hospitals, New York, NY 10016, USA
    Division of Biostatistics, Department of Population Health, New York University Grossman School of Medicine, New York, NY 10016, USA)

  • Joan Reibman

    (Department of Environmental Medicine, New York University Grossman School of Medicine, New York, NY 10010, USA
    Division of Pulmonary Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA
    World Trade Center Environmental Health Center, NYC Health + Hospitals, New York, NY 10016, USA)

Abstract

The destruction of the World Trade Center (WTC) on September 11, 2001 (9/11) released large amounts of toxic dusts and fumes into the air that exposed many community members who lived and/or worked in the local area. Many community members, defined as WTC survivors by the federal government, developed lower respiratory symptoms (LRS). We previously reported the persistence of these symptoms in patients with normal spirometry despite treatment with inhaled corticosteroids and/or long-acting bronchodilators. This report expands upon our study of this group with the goal to identify molecular markers associated with exposure and heterogeneity in WTC survivors with LRS using a selected plasma biomarker approach. Samples from WTC survivors with LRS ( n = 73, WTCS) and samples from healthy control participants of the NYU Bellevue Asthma Registry (NYUBAR, n = 55) were compared. WTCS provided information regarding WTC dust exposure intensity. Hierarchical clustering of the linear biomarker data identified two clusters within WTCS and two clusters within NYUBAR controls. Comparison of the WTCS clusters showed that one cluster had significantly increased levels of circulating matrix metalloproteinases (MMP1, 2, 3, 8, 12, 13), soluble inflammatory receptors (receptor for advanced glycation end-products-RAGE, Interleukin-1 receptor antagonist (IL-1RA), suppression of tumorigenicity (ST)2, triggering receptor expressed on myeloid cells (TREM)1, IL-6Ra, tumor necrosis factor (TNF)RI, TNFRII), and chemokines (IL-8, CC chemokine ligand- CCL17). Furthermore, this WTCS cluster was associated with WTC exposure variables, ash at work, and the participant category workers; but not with the exposure variable WTC dust cloud at 9/11. A comparison of WTC exposure categorial variables identified that chemokines (CCL17, CCL11), circulating receptors (RAGE, TREM1), MMPs (MMP3, MMP12), and vascular markers (Angiogenin, vascular cell adhesion molecule-VCAM1) significantly increased in the more exposed groups. Circulating biomarkers of remodeling and inflammation identified clusters within WTCS and were associated with WTC exposure.

Suggested Citation

  • Gabriele Grunig & Nedim Durmus & Yian Zhang & Yuting Lu & Sultan Pehlivan & Yuyan Wang & Kathleen Doo & Maria L. Cotrina-Vidal & Roberta Goldring & Kenneth I. Berger & Mengling Liu & Yongzhao Shao & J, 2022. "Molecular Clustering Analysis of Blood Biomarkers in World Trade Center Exposed Community Members with Persistent Lower Respiratory Symptoms," IJERPH, MDPI, vol. 19(13), pages 1-18, July.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:13:p:8102-:d:853945
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/13/8102/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/19/13/8102/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Yongzhao Shao & Nedim Durmus & Yian Zhang & Sultan Pehlivan & Maria-Elena Fernandez-Beros & Lisette Umana & Rachel Corona & Adrienne Addessi & Sharon A. Abbott & Sheila Smyth-Giambanco & Alan A. Arsla, 2021. "The Development of a WTC Environmental Health Center Pan-Cancer Database," IJERPH, MDPI, vol. 18(4), pages 1-18, February.
    2. Alan A. Arslan & Stephanie Tuminello & Lei Yang & Yian Zhang & Nedim Durmus & Matija Snuderl & Adriana Heguy & Anne Zeleniuch-Jacquotte & Yongzhao Shao & Joan Reibman, 2020. "Genome-Wide DNA Methylation Profiles in Community Members Exposed to the World Trade Center Disaster," IJERPH, MDPI, vol. 17(15), pages 1-13, July.
    3. Sophia Kwon & George Crowley & Mena Mikhail & Rachel Lam & Emily Clementi & Rachel Zeig-Owens & Theresa M. Schwartz & Mengling Liu & David J. Prezant & Anna Nolan, 2019. "Metabolic Syndrome Biomarkers of World Trade Center Airway Hyperreactivity: A 16-Year Prospective Cohort Study," IJERPH, MDPI, vol. 16(9), pages 1-14, April.
    4. Rebecca Rosen & Zhaoyin Zhu & Yongzhao Shao & Mengling Liu & Jia Bao & Nomi Levy-Carrick & Joan Reibman, 2019. "Longitudinal Change of PTSD Symptoms in Community Members after the World Trade Center Destruction," IJERPH, MDPI, vol. 16(7), pages 1-12, April.
    5. Alan A. Arslan & Yian Zhang & Nedim Durmus & Sultan Pehlivan & Adrienne Addessi & Freya Schnabel & Yongzhao Shao & Joan Reibman, 2021. "Breast Cancer Characteristics in the Population of Survivors Participating in the World Trade Center Environmental Health Center Program 2002–2019," IJERPH, MDPI, vol. 18(14), pages 1-11, July.
    6. Ridhwan Y. Baba & Yian Zhang & Yongzhao Shao & Kenneth I. Berger & Roberta M. Goldring & Mengling Liu & Angeliki Kazeros & Rebecca Rosen & Joan Reibman, 2022. "COPD in Smoking and Non-Smoking Community Members Exposed to the World Trade Center Dust and Fumes," IJERPH, MDPI, vol. 19(7), pages 1-12, April.
    7. Nedim Durmus & Sultan Pehlivan & Yian Zhang & Yongzhao Shao & Alan A. Arslan & Rachel Corona & Ian Henderson & Daniel H. Sterman & Joan Reibman, 2021. "Lung Cancer Characteristics in the World Trade Center Environmental Health Center," IJERPH, MDPI, vol. 18(5), pages 1-14, March.
    8. Miranda J. Spratlen & Frederica P. Perera & Andreas Sjodin & Yuyan Wang & Julie B. Herbstman & Leonardo Trasande, 2022. "Understanding the Role of Persistent Organic Pollutants and Stress in the Association between Proximity to the World Trade Center Disaster and Birth Outcomes," IJERPH, MDPI, vol. 19(4), pages 1-16, February.
    9. Rebecca Rosen & Yongzhao Shao & Qiao Zhang & Jia Bao & Yian Zhang & Arjun Masurkar & Thomas Wisniewski & Nina Urban & Joan Reibman, 2022. "Cognitive Function among World Trade Center-Exposed Community Members with Mental Health Symptoms," IJERPH, MDPI, vol. 19(6), pages 1-13, March.
    10. Rachel Lam & Syed H. Haider & George Crowley & Erin J. Caraher & Dean F. Ostrofsky & Angela Talusan & Sophia Kwon & David J. Prezant & Yuyan Wang & Mengling Liu & Anna Nolan, 2020. "Synergistic Effect of WTC-Particulate Matter and Lysophosphatidic Acid Exposure and the Role of RAGE: In-Vitro and Translational Assessment," IJERPH, MDPI, vol. 17(12), pages 1-22, June.
    11. Joan Reibman & Caralee Caplan-Shaw & Yinxiang Wu & Mengling Liu & Milan R. Amin & Kenneth I. Berger & Maria L. Cotrina-Vidal & Angeliki Kazeros & Nedim Durmus & Maria-Elena Fernandez-Beros & Roberta M, 2020. "Characterization of Persistent Uncontrolled Asthma Symptoms in Community Members Exposed to World Trade Center Dust and Fumes," IJERPH, MDPI, vol. 17(18), pages 1-17, September.
    12. Nedim Durmus & Yongzhao Shao & Alan A. Arslan & Yian Zhang & Sultan Pehlivan & Maria-Elena Fernandez-Beros & Lisette Umana & Rachel Corona & Sheila Smyth-Giambanco & Sharon A. Abbott & Joan Reibman, 2020. "Characteristics of Cancer Patients in the World Trade Center Environmental Health Center," IJERPH, MDPI, vol. 17(19), pages 1-15, October.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Yian Zhang & Rebecca Rosen & Joan Reibman & Yongzhao Shao, 2022. "Posttraumatic Stress Disorder Mediates the Association between Traumatic World Trade Center Dust Cloud Exposure and Ongoing Systemic Inflammation in Community Members," IJERPH, MDPI, vol. 19(14), pages 1-16, July.
    2. Stephanie Tuminello & Yian Zhang & Lei Yang & Nedim Durmus & Matija Snuderl & Adriana Heguy & Anne Zeleniuch-Jacquotte & Yu Chen & Yongzhao Shao & Joan Reibman & Alan A. Arslan, 2022. "Global DNA Methylation Profiles in Peripheral Blood of WTC-Exposed Community Members with Breast Cancer," IJERPH, MDPI, vol. 19(9), pages 1-15, April.
    3. James E. Cone & Albeliz Santiago-Colón & Roberto Lucchini, 2021. "9/11 Health Update," IJERPH, MDPI, vol. 18(12), pages 1-5, June.
    4. Rebecca Lynn Florsheim & Qiao Zhang & Nedim Durmus & Yian Zhang & Sultan Pehlivan & Alan A. Arslan & Yongzhao Shao & Joan Reibman, 2022. "Characteristics of Cancers in Community Members Exposed to the World Trade Center Disaster at a Young Age," IJERPH, MDPI, vol. 19(22), pages 1-17, November.
    5. Yongzhao Shao & Nedim Durmus & Yian Zhang & Sultan Pehlivan & Maria-Elena Fernandez-Beros & Lisette Umana & Rachel Corona & Adrienne Addessi & Sharon A. Abbott & Sheila Smyth-Giambanco & Alan A. Arsla, 2021. "The Development of a WTC Environmental Health Center Pan-Cancer Database," IJERPH, MDPI, vol. 18(4), pages 1-18, February.
    6. Rebecca Rosen & Yongzhao Shao & Qiao Zhang & Jia Bao & Yian Zhang & Arjun Masurkar & Thomas Wisniewski & Nina Urban & Joan Reibman, 2022. "Cognitive Function among World Trade Center-Exposed Community Members with Mental Health Symptoms," IJERPH, MDPI, vol. 19(6), pages 1-13, March.
    7. Elaine Shum & Nedim Durmus & Sultan Pehlivan & Yuting Lu & Yian Zhang & Alan A. Arslan & Yongzhao Shao & Joan Reibman, 2022. "Characteristics of Women with Lung Adenocarcinoma in the World Trade Center Environmental Health Center," IJERPH, MDPI, vol. 19(13), pages 1-10, June.
    8. Nedim Durmus & Sultan Pehlivan & Yian Zhang & Yongzhao Shao & Alan A. Arslan & Rachel Corona & Ian Henderson & Daniel H. Sterman & Joan Reibman, 2021. "Lung Cancer Characteristics in the World Trade Center Environmental Health Center," IJERPH, MDPI, vol. 18(5), pages 1-14, March.
    9. Robert M. Brackbill & Judith M. Graber & William A. (Allen) Robison, 2019. "Editorial for “Long-Term Health Effects of the 9/11 Disaster” in International Journal of Environmental Research and Public Health , 2019," IJERPH, MDPI, vol. 16(18), pages 1-6, September.
    10. Alan A. Arslan & Yian Zhang & Nedim Durmus & Sultan Pehlivan & Adrienne Addessi & Freya Schnabel & Yongzhao Shao & Joan Reibman, 2021. "Breast Cancer Characteristics in the Population of Survivors Participating in the World Trade Center Environmental Health Center Program 2002–2019," IJERPH, MDPI, vol. 18(14), pages 1-11, July.
    11. Julia Citron & Emma Willcocks & George Crowley & Sophia Kwon & Anna Nolan, 2019. "Genomics of Particulate Matter Exposure Associated Cardiopulmonary Disease: A Narrative Review," IJERPH, MDPI, vol. 16(22), pages 1-11, November.
    12. Ashley Beckett & Jake Riley Scott & Angel Marie Chater & Louise Ferrandino & Jeffrey William Frederick Aldous, 2023. "The Prevalence of Metabolic Syndrome and Its Components in Firefighters: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 20(19), pages 1-14, September.
    13. Joan Reibman & Caralee Caplan-Shaw & Yinxiang Wu & Mengling Liu & Milan R. Amin & Kenneth I. Berger & Maria L. Cotrina-Vidal & Angeliki Kazeros & Nedim Durmus & Maria-Elena Fernandez-Beros & Roberta M, 2020. "Characterization of Persistent Uncontrolled Asthma Symptoms in Community Members Exposed to World Trade Center Dust and Fumes," IJERPH, MDPI, vol. 17(18), pages 1-17, September.
    14. Ridhwan Y. Baba & Yian Zhang & Yongzhao Shao & Kenneth I. Berger & Roberta M. Goldring & Mengling Liu & Angeliki Kazeros & Rebecca Rosen & Joan Reibman, 2022. "COPD in Smoking and Non-Smoking Community Members Exposed to the World Trade Center Dust and Fumes," IJERPH, MDPI, vol. 19(7), pages 1-12, April.
    15. Rachel Lam & Syed H. Haider & George Crowley & Erin J. Caraher & Dean F. Ostrofsky & Angela Talusan & Sophia Kwon & David J. Prezant & Yuyan Wang & Mengling Liu & Anna Nolan, 2020. "Synergistic Effect of WTC-Particulate Matter and Lysophosphatidic Acid Exposure and the Role of RAGE: In-Vitro and Translational Assessment," IJERPH, MDPI, vol. 17(12), pages 1-22, June.
    16. Cortes, Darwin & Gómez, Catalina & Posso, Christian & Suarez, Gabriel, 2023. "Hunting Militias at All Cost: Urban Military Operation and Birth Outcomes," Documentos de Trabajo 20935, Universidad del Rosario.
    17. Meghan K. Hamwey & Lisa M. Gargano & Liza G. Friedman & Lydia F. Leon & Lysa J. Petrsoric & Robert M. Brackbill, 2020. "Post-Traumatic Stress Disorder among Survivors of the September 11, 2001 World Trade Center Attacks: A Review of the Literature," IJERPH, MDPI, vol. 17(12), pages 1-22, June.
    18. Sophia Kwon & Jessica Riggs & George Crowley & Rachel Lam & Isabel R. Young & Christine Nayar & Maria Sunseri & Mena Mikhail & Dean Ostrofsky & Arul Veerappan & Rachel Zeig-Owens & Theresa Schwartz & , 2020. "Food Intake REstriction for Health OUtcome Support and Education (FIREHOUSE) Protocol: A Randomized Clinical Trial," IJERPH, MDPI, vol. 17(18), pages 1-15, September.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:13:p:8102-:d:853945. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.