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Lung Cancer Characteristics in the World Trade Center Environmental Health Center

Author

Listed:
  • Nedim Durmus

    (Department of Medicine, Division of Pulmonary Medicine, School of Medicine (SOM), New York University, New York, NY 10016, USA
    World Trade Center Environmental Health Center, NYC H+HC, New York, NY 10016, USA)

  • Sultan Pehlivan

    (Department of Medicine, Division of Pulmonary Medicine, School of Medicine (SOM), New York University, New York, NY 10016, USA
    World Trade Center Environmental Health Center, NYC H+HC, New York, NY 10016, USA)

  • Yian Zhang

    (World Trade Center Environmental Health Center, NYC H+HC, New York, NY 10016, USA
    Department of Population Health, Division of Biostatistics, School of Medicine (SOM), New York University, New York, NY 10016, USA)

  • Yongzhao Shao

    (World Trade Center Environmental Health Center, NYC H+HC, New York, NY 10016, USA
    Department of Population Health, Division of Biostatistics, School of Medicine (SOM), New York University, New York, NY 10016, USA
    Department of Environmental Medicine, School of Medicine (SOM), New York University, New York, NY 10016, USA
    NYU Perlmutter Comprehensive Cancer Center, New York, NY 10016, USA)

  • Alan A. Arslan

    (World Trade Center Environmental Health Center, NYC H+HC, New York, NY 10016, USA
    Department of Population Health, Division of Biostatistics, School of Medicine (SOM), New York University, New York, NY 10016, USA
    Department of Environmental Medicine, School of Medicine (SOM), New York University, New York, NY 10016, USA
    NYU Perlmutter Comprehensive Cancer Center, New York, NY 10016, USA)

  • Rachel Corona

    (World Trade Center Environmental Health Center, NYC H+HC, New York, NY 10016, USA)

  • Ian Henderson

    (Department of Medicine, Division of Pulmonary Medicine, School of Medicine (SOM), New York University, New York, NY 10016, USA)

  • Daniel H. Sterman

    (Department of Medicine, Division of Pulmonary Medicine, School of Medicine (SOM), New York University, New York, NY 10016, USA)

  • Joan Reibman

    (Department of Medicine, Division of Pulmonary Medicine, School of Medicine (SOM), New York University, New York, NY 10016, USA
    World Trade Center Environmental Health Center, NYC H+HC, New York, NY 10016, USA
    Department of Environmental Medicine, School of Medicine (SOM), New York University, New York, NY 10016, USA)

Abstract

The destruction of the World Trade Center (WTC) towers on 11 September 2001 resulted in acute and chronic dust and fume exposures to community members, including local workers and residents, with well-described aerodigestive adverse health effects. This study aimed to characterize lung cancer in the WTC Environmental Health Center (WTC EHC) focusing on gender and smoking history. WTC EHC patients undergo an initial evaluation that includes WTC exposure information, demographics, and tobacco use. Detailed cancer characteristics are recorded from pathology reports. As of 31 December 2019, 248 WTC EHC patients had a diagnosis of lung cancer. More patients with lung cancer were women (57%) compared to men (43%). Many cases (47% women, 51% men) reported acute dust cloud exposure. Thirty-seven percent of lung cancer cases with available smoking history were never-smokers (≤1 pack-years) and 42% had a ≤5 pack-year history. The median age of cancer diagnosis in never-smoking women was 61 years compared to 66 years in men. Adenocarcinoma was more common in never-smokers compared to ever-smokers (72% vs. 65%) and in women compared to men (70% vs. 65%). We provide an initial description of lung cancers in local community members with documented exposure to the WTC dust and fumes.

Suggested Citation

  • Nedim Durmus & Sultan Pehlivan & Yian Zhang & Yongzhao Shao & Alan A. Arslan & Rachel Corona & Ian Henderson & Daniel H. Sterman & Joan Reibman, 2021. "Lung Cancer Characteristics in the World Trade Center Environmental Health Center," IJERPH, MDPI, vol. 18(5), pages 1-14, March.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:5:p:2689-:d:512264
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    References listed on IDEAS

    as
    1. Yongzhao Shao & Nedim Durmus & Yian Zhang & Sultan Pehlivan & Maria-Elena Fernandez-Beros & Lisette Umana & Rachel Corona & Adrienne Addessi & Sharon A. Abbott & Sheila Smyth-Giambanco & Alan A. Arsla, 2021. "The Development of a WTC Environmental Health Center Pan-Cancer Database," IJERPH, MDPI, vol. 18(4), pages 1-18, February.
    2. Rebecca Rosen & Zhaoyin Zhu & Yongzhao Shao & Mengling Liu & Jia Bao & Nomi Levy-Carrick & Joan Reibman, 2019. "Longitudinal Change of PTSD Symptoms in Community Members after the World Trade Center Destruction," IJERPH, MDPI, vol. 16(7), pages 1-12, April.
    3. Stephanie Tuminello & Maaike A. G. van Gerwen & Eric Genden & Michael Crane & Wil Lieberman-Cribbin & Emanuela Taioli, 2019. "Increased Incidence of Thyroid Cancer among World Trade Center First Responders: A Descriptive Epidemiological Assessment," IJERPH, MDPI, vol. 16(7), pages 1-8, April.
    4. Kerry M. Hena & Scarlett Murphy & Yian Zhang & Yongzhao Shao & Angeliki Kazeros & Joan Reibman, 2019. "Clinical Evaluation of Sarcoidosis in Community Members with World Trade Center Dust Exposure," IJERPH, MDPI, vol. 16(7), pages 1-9, April.
    5. Nedim Durmus & Yongzhao Shao & Alan A. Arslan & Yian Zhang & Sultan Pehlivan & Maria-Elena Fernandez-Beros & Lisette Umana & Rachel Corona & Sheila Smyth-Giambanco & Sharon A. Abbott & Joan Reibman, 2020. "Characteristics of Cancer Patients in the World Trade Center Environmental Health Center," IJERPH, MDPI, vol. 17(19), pages 1-15, October.
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    Cited by:

    1. James E. Cone & Albeliz Santiago-Colón & Roberto Lucchini, 2021. "9/11 Health Update," IJERPH, MDPI, vol. 18(12), pages 1-5, June.
    2. Elaine Shum & Nedim Durmus & Sultan Pehlivan & Yuting Lu & Yian Zhang & Alan A. Arslan & Yongzhao Shao & Joan Reibman, 2022. "Characteristics of Women with Lung Adenocarcinoma in the World Trade Center Environmental Health Center," IJERPH, MDPI, vol. 19(13), pages 1-10, June.
    3. Gabriele Grunig & Nedim Durmus & Yian Zhang & Yuting Lu & Sultan Pehlivan & Yuyan Wang & Kathleen Doo & Maria L. Cotrina-Vidal & Roberta Goldring & Kenneth I. Berger & Mengling Liu & Yongzhao Shao & J, 2022. "Molecular Clustering Analysis of Blood Biomarkers in World Trade Center Exposed Community Members with Persistent Lower Respiratory Symptoms," IJERPH, MDPI, vol. 19(13), pages 1-18, July.

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