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Increased Incidence of Thyroid Cancer among World Trade Center First Responders: A Descriptive Epidemiological Assessment

Author

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  • Stephanie Tuminello

    (Institute for Translational Epidemiology and Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA)

  • Maaike A. G. van Gerwen

    (Institute for Translational Epidemiology and Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA)

  • Eric Genden

    (Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA)

  • Michael Crane

    (Division of Occupational and Environmental Medicine, Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA)

  • Wil Lieberman-Cribbin

    (Institute for Translational Epidemiology and Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA)

  • Emanuela Taioli

    (Institute for Translational Epidemiology and Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
    Department of Thoracic Surgery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
    Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA)

Abstract

An increased incidence of thyroid cancer among 9/11 rescue workers has been reported, the etiology of which remains unclear but which may, at least partly, be the result of the increased medical surveillance this group undergoes. This study aimed to investigate thyroid cancer in World Trade Center (WTC) responders by looking at the demographic data and questionnaire responses of thyroid cancer cases from the Mount Sinai WTC Health Program (WTCHP). WTCHP thyroid cancer tumors were of a similar size ( p = 0.4), and were diagnosed at a similar age ( p = 0.2) compared to a subset of thyroid cancer cases treated at Mount Sinai without WTC exposure. These results do not support the surveillance bias hypothesis, under which smaller tumors are expected to be diagnosed at earlier ages. WTCHP thyroid cancer cases also reported a past history of radiation exposure and a family history of thyroid conditions at lower rates than expected, with higher than expected rates of previous cancer diagnoses, family histories of other cancers, and high Body Mass Indexes (BMIs). Further research is needed to better understand the underlying risk factors that may play a role in the development of thyroid cancer in this group.

Suggested Citation

  • Stephanie Tuminello & Maaike A. G. van Gerwen & Eric Genden & Michael Crane & Wil Lieberman-Cribbin & Emanuela Taioli, 2019. "Increased Incidence of Thyroid Cancer among World Trade Center First Responders: A Descriptive Epidemiological Assessment," IJERPH, MDPI, vol. 16(7), pages 1-8, April.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:7:p:1258-:d:221028
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    References listed on IDEAS

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    1. María Elena Martínez & Jonathan T Unkart & Li Tao & Candyce H Kroenke & Richard Schwab & Ian Komenaka & Scarlett Lin Gomez, 2017. "Prognostic significance of marital status in breast cancer survival: A population-based study," PLOS ONE, Public Library of Science, vol. 12(5), pages 1-14, May.
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    Cited by:

    1. Albeliz Santiago-Colón & Robert Daniels & Dori Reissman & Kristi Anderson & Geoffrey Calvert & Alexis Caplan & Tania Carreón & Alan Katruska & Travis Kubale & Ruiling Liu & Rhonda Nembhard & W. Allen , 2020. "World Trade Center Health Program: First Decade of Research," IJERPH, MDPI, vol. 17(19), pages 1-25, October.
    2. Maaike A. G. van Gerwen & Stephanie Tuminello & Gregory J. Riggins & Thais B. Mendes & Michael Donovan & Emma K.T. Benn & Eric Genden & Janete M. Cerutti & Emanuela Taioli, 2019. "Molecular Study of Thyroid Cancer in World Trade Center Responders," IJERPH, MDPI, vol. 16(9), pages 1-7, May.
    3. Nedim Durmus & Yongzhao Shao & Alan A. Arslan & Yian Zhang & Sultan Pehlivan & Maria-Elena Fernandez-Beros & Lisette Umana & Rachel Corona & Sheila Smyth-Giambanco & Sharon A. Abbott & Joan Reibman, 2020. "Characteristics of Cancer Patients in the World Trade Center Environmental Health Center," IJERPH, MDPI, vol. 17(19), pages 1-15, October.
    4. Elaine Shum & Nedim Durmus & Sultan Pehlivan & Yuting Lu & Yian Zhang & Alan A. Arslan & Yongzhao Shao & Joan Reibman, 2022. "Characteristics of Women with Lung Adenocarcinoma in the World Trade Center Environmental Health Center," IJERPH, MDPI, vol. 19(13), pages 1-10, June.
    5. Rebecca Lynn Florsheim & Qiao Zhang & Nedim Durmus & Yian Zhang & Sultan Pehlivan & Alan A. Arslan & Yongzhao Shao & Joan Reibman, 2022. "Characteristics of Cancers in Community Members Exposed to the World Trade Center Disaster at a Young Age," IJERPH, MDPI, vol. 19(22), pages 1-17, November.
    6. Robert M. Brackbill & Judith M. Graber & William A. (Allen) Robison, 2019. "Editorial for “Long-Term Health Effects of the 9/11 Disaster” in International Journal of Environmental Research and Public Health , 2019," IJERPH, MDPI, vol. 16(18), pages 1-6, September.
    7. Nedim Durmus & Sultan Pehlivan & Yian Zhang & Yongzhao Shao & Alan A. Arslan & Rachel Corona & Ian Henderson & Daniel H. Sterman & Joan Reibman, 2021. "Lung Cancer Characteristics in the World Trade Center Environmental Health Center," IJERPH, MDPI, vol. 18(5), pages 1-14, March.

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